CT guided diffuse optical tomography for breast cancer imaging

Diffuse optical tomography (DOT) has attracted attentions in the last two decades due to its intrinsic sensitivity in imaging chromophores of tissues such as blood, water, and lipid. However, DOT has not been clinically accepted yet due to its low spatial resolution caused by strong optical scattering in tissues. Structural guidance provided by an anatomical imaging modality enhances the DOT imaging substantially. Here, we propose a computed tomography (CT) guided multispectral DOT imaging system for breast cancer detection. To validate its feasibility, we have built a prototype DOT imaging system which consists of a laser at wavelengths of 650 and an electron multiplying charge coupled device (EMCCD) camera. We have validated the CT guided DOT reconstruction algorithms with numerical simulations and phantom experiments, in which different imaging setup parameters, such as projection number of measurements, the width of measurement patch, have been investigated. Our results indicate that an EMCCD camera with air cooling is good enough for the transmission mode DOT imaging. We have also found that measurements at six projections are sufficient for DOT to reconstruct the optical targets with 4 times absorption contrast when the CT guidance is applied. Finally, we report our effort and progress on the integration of the multispectral DOT imaging system into a breast CT scanner.

[1]  V. Ntziachristos,et al.  Three-dimensional diffuse optical tomography in the parallel plane transmission geometry: evaluation of a hybrid frequency domain/continuous wave clinical system for breast imaging. , 2003, Medical physics.

[2]  A. N. Tikhonov,et al.  REGULARIZATION OF INCORRECTLY POSED PROBLEMS , 1963 .

[3]  G. Hortobagyi,et al.  Advanced primary breast cancer: assessment at mammography of response to induction chemotherapy. , 1988, Radiology.

[4]  Randall L. Barbour,et al.  A perturbation approach for optical diffusion tomography using continuous-wave and time-resolved data , 1993, Other Conferences.

[5]  Huabei Jiang,et al.  Multispectral breast imaging using a ten-wavelength, 64 x 64 source/detector channels silicon photodiode-based diffuse optical tomography system. , 2006, Medical physics.

[6]  M. Huang,et al.  Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. , 2005, Radiology.

[7]  Eric L. Miller,et al.  Combined optical imaging and mammography of the healthy breast: Optical contrast derived from breast structure and compression , 2009, IEEE Transactions on Medical Imaging.

[8]  Akira Ishimaru,et al.  Wave propagation and scattering in random media , 1997 .

[9]  A. Hielscher,et al.  Instrumentation for fast functional optical tomography , 2002 .

[10]  E. Miller,et al.  Tomographic optical breast imaging guided by three-dimensional mammography. , 2003, Applied optics.

[11]  Eric L. Miller,et al.  Imaging the body with diffuse optical tomography , 2001, IEEE Signal Process. Mag..

[12]  M. Huang,et al.  Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers. , 2005, Neoplasia.

[13]  E. Miller,et al.  Quantitative spectroscopic diffuse optical tomography of the breast guided by imperfect a priori structural information , 2005, Physics in medicine and biology.

[14]  Feng Gao,et al.  Improvement of image quality in diffuse optical tomography by use of full time-resolved data. , 2002, Applied optics.

[15]  B. Pogue,et al.  Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography. , 2007, Medical physics.

[16]  A. Yodh,et al.  Diffuse optics for tissue monitoring and tomography , 2010, Reports on progress in physics. Physical Society.

[17]  Wendy B DeMartini,et al.  Targeted ultrasound in women younger than 30 years with focal breast signs or symptoms: outcomes analyses and management implications. , 2010, AJR. American journal of roentgenology.

[18]  S. Colak,et al.  Clinical optical tomography and NIR spectroscopy for breast cancer detection , 1999 .

[19]  John M. Boone,et al.  Computed Tomography for Imaging the Breast , 2006, Journal of Mammary Gland Biology and Neoplasia.

[20]  K. Paulsen,et al.  Spatially varying optical property reconstruction using a finite element diffusion equation approximation. , 1995, Medical physics.

[21]  K D Paulsen,et al.  Initial assessment of a simple system for frequency domain diffuse optical tomography. , 1995, Physics in medicine and biology.

[22]  A. Darzi,et al.  Diffuse optical imaging of the healthy and diseased breast: A systematic review , 2008, Breast Cancer Research and Treatment.

[23]  S R Arridge,et al.  Recent advances in diffuse optical imaging , 2005, Physics in medicine and biology.

[24]  R. Gilles,et al.  Locally advanced breast cancer: contrast-enhanced subtraction MR imaging of response to preoperative chemotherapy. , 1994, Radiology.

[25]  K D Paulsen,et al.  Calibration of near-infrared frequency-domain tissue spectroscopy for absolute absorption coefficient quantitation in neonatal head-simulating phantoms. , 2000, Journal of biomedical optics.

[26]  M. Schweiger,et al.  Uniqueness and wavelength optimization in continuous-wave multispectral diffuse optical tomography. , 2003, Optics letters.

[27]  E. Miller,et al.  Optimal linear inverse solution with multiple priors in diffuse optical tomography. , 2005, Applied optics.

[28]  Huabei Jiang,et al.  A calibration method in diffuse optical tomography , 2004 .

[29]  P J Drew,et al.  Evaluation of response to neoadjuvant chemoradiotherapy for locally advanced breast cancer with dynamic contrast-enhanced MRI of the breast. , 2001, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[30]  B. Pogue,et al.  A parallel-detection frequency-domain near-infrared tomography system for hemoglobin imaging of the , 2001 .

[31]  M. Huang,et al.  Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases. , 2003, Neoplasia.

[32]  Hamid Dehghani,et al.  Implicit and explicit prior information in near-infrared spectral imaging: accuracy, quantification and diagnostic value , 2011, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

[33]  Sandra K. Soho,et al.  Characterization of hemoglobin, water, and NIR scattering in breast tissue: analysis of intersubject variability and menstrual cycle changes. , 2004, Journal of biomedical optics.

[34]  D. Boas,et al.  Experimental images of heterogeneous turbid media by frequency-domain diffusing-photon tomography. , 1995, Optics letters.

[35]  V. Ntziachristos,et al.  MRI-guided diffuse optical spectroscopy of malignant and benign breast lesions. , 2002, Neoplasia.

[36]  Bernhard Brendel,et al.  Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging , 2009, European Radiology.

[37]  Huabei Jiang,et al.  Multispectral diffuse optical tomography with absorption and scattering spectral constraints. , 2007, Applied optics.

[38]  S. Arridge.  Optical tomography in medical imaging , 1999 .

[39]  B. Pogue,et al.  Spectrally constrained chromophore and scattering near-infrared tomography provides quantitative and robust reconstruction. , 2005, Applied optics.

[40]  R. Barbour,et al.  Normalized-constraint algorithm for minimizing inter-parameter crosstalk in DC optical tomography. , 2001, Optics express.

[41]  J. Marota,et al.  Design and evaluation of a continuous-wave diffuse optical tomography system. , 1999, Optics express.

[42]  B. Tromberg,et al.  Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration. , 1997, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[43]  C. Pichot,et al.  Microwave imaging-complex permittivity reconstruction with a Levenberg-Marquardt method , 1997 .

[44]  K Paulsen,et al.  Instrumentation and design of a frequency-domain diffuse optical tomography imager for breast cancer detection. , 1997, Optics express.

[45]  N. Iftimia,et al.  Imaging of in vitro and in vivo bones and joints with continuous-wave diffuse optical tomography. , 2001, Optics express.

[46]  E. Miller,et al.  Combined optical and X-ray tomosynthesis breast imaging. , 2011, Radiology.

[47]  Britton Chance,et al.  Diffuse optical tomography with physiological and spatial a priori constraints , 2004, Physics in medicine and biology.

[48]  Lihong V. Wang,et al.  Biomedical Optics: Principles and Imaging , 2007 .

[49]  Hamid Dehghani,et al.  Structural information within regularization matrices improves near infrared diffuse optical tomography. , 2007, Optics express.

[50]  S. Arridge,et al.  Optical tomography: forward and inverse problems , 2009, 0907.2586.

[51]  B. Pogue,et al.  Combining near-infrared tomography and magnetic resonance imaging to study in vivo breast tissue: implementation of a Laplacian-type regularization to incorporate magnetic resonance structure. , 2005, Journal of biomedical optics.

[52]  N. Dubrawsky.  Cancer statistics , 1989, CA: a cancer journal for clinicians.

[53]  R. Barbour,et al.  Frequency-domain optical imaging of absorption and scattering distributions by a Born iterative method. , 1997, Journal of the Optical Society of America. A, Optics, image science, and vision.

[54]  C. Quinn,et al.  Angiogenesis, thrombospondin, and ductal carcinoma in situ of the breast , 2002, Journal of clinical pathology.

[55]  Vasilis Ntziachristos,et al.  Complete-angle projection diffuse optical tomography by use of early photons. , 2005, Optics letters.

[56]  A. Jemal,et al.  Cancer Statistics, 2007 , 2007, CA: a cancer journal for clinicians.

[57]  S. Arridge,et al.  Optical imaging in medicine: II. Modelling and reconstruction , 1997, Physics in medicine and biology.

[58]  B. Pogue,et al.  Imaging breast adipose and fibroglandular tissue molecular signatures by using hybrid MRI-guided near-infrared spectral tomography. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[59]  K D Paulsen,et al.  Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue. , 1999, Applied optics.

[60]  M. Schweiger,et al.  A finite element approach for modeling photon transport in tissue. , 1993, Medical physics.

[61]  S R Arridge,et al.  Three-dimensional time-resolved optical tomography of a conical breast phantom. , 2001, Applied optics.

[62]  M. Yaffe,et al.  American Cancer Society Guidelines for Breast Screening with MRI as an Adjunct to Mammography , 2007 .

[63]  Hamid Dehghani,et al.  Near infrared optical tomography using NIRFAST: Algorithm for numerical model and image reconstruction. , 2009, Communications in numerical methods in engineering.

[64]  B. Pogue,et al.  Optical image reconstruction using frequency-domain data: simulations and experiments , 1996 .

[65]  C. Balu-Maestro,et al.  Imaging in evaluation of response to neoadjuvant breast cancer treatment benefits of MRI. , 2005, Breast cancer research and treatment.

[66]  L. Fajardo,et al.  Near-infrared optical imaging of the breast with model-based reconstruction. , 2002, Academic radiology.

[67]  Arjun G. Yodh,et al.  Diffuse optical measurement of blood flow in breast tumors , 2005 .

[68]  Kai Yang,et al.  A geometric calibration method for cone beam CT systems. , 2006, Medical physics.

[69]  E. Miller,et al.  Reconstructing chromosphere concentration images directly by continuous-wave diffuse optical tomography. , 2004, Optics letters.

[70]  B. Pogue,et al.  Near-infrared (NIR) tomography breast image reconstruction with a priori structural information from MRI: algorithm development for reconstructing heterogeneities , 2003 .

[71]  L. Tabár,et al.  Mammography service screening and mortality in breast cancer patients: 20-year follow-up before and after introduction of screening , 2003, The Lancet.

[72]  K D Paulsen,et al.  Simultaneous reconstruction of optical absorption and scattering maps in turbid media from near-infrared frequency-domain data. , 1995, Optics letters.