Complementary roles for lipid and protein allergens in triggering innate and adaptive immune systems

Background:  Recent advances in allergy research mostly focussed on two major headings: improving protein allergen purification, which is aimed towards a better characterization of IgE‐ and T‐cell reactive epitopes, and the potential new role for unconventional innate and regulatory T cells in controlling airway inflammation. These advancements could appear to be in conflict each other, as innate T cells have a poorly‐defined antigen specificity that is often directed toward nonprotein substances, such as lipids.

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