Human pitch perception is reflected in the timing of stimulus-related cortical activity

'Pitch' refers to a sound's subjective highness or lowness, as distinct from 'frequency,' which refers to a sound's physical structure. In speech, music and other natural contexts, complex tones are often perceived with a single pitch. Using whole-head magnetoencephalography (MEG) and stimuli that dissociate pitch from frequency, we studied cortical dynamics in normal individuals who extracted different pitches from the same tone complexes. Whereas all subjects showed similar spatial distributions in the magnitude of their brain responses to the stimuli, subjects who heard different pitches exhibited contrasting temporal patterns of brain activity in their right but not their left hemispheres. These data demonstrate a specific relationship between pitch perception and the timing (phase) of dynamic patterns of cortical activity.

[1]  Bernice W. Polemis.  Nonparametric Statistics for the Behavioral Sciences , 1959 .

[2]  J. L. Goldstein.  An optimum processor theory for the central formation of the pitch of complex tones. , 1973, The Journal of the Acoustical Society of America.

[3]  E. Terhardt.  Pitch, consonance, and harmony. , 1974, The Journal of the Acoustical Society of America.

[4]  S. Makeig,et al.  A 40-Hz auditory potential recorded from the human scalp. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Steven Greenberg,et al.  Neural temporal coding of low pitch. I. Human frequency-following responses to complex tones , 1987, Hearing Research.

[6]  R. Zatorre,et al.  Pitch perception of complex tones and human temporal-lobe function. , 1988, The Journal of the Acoustical Society of America.

[7]  C. Schreiner,et al.  Periodicity coding in the inferior colliculus of the cat. I. Neuronal mechanisms. , 1988, Journal of neurophysiology.

[8]  M Hämäläinen,et al.  Neuromagnetic steady-state responses to auditory stimuli. , 1989, The Journal of the Acoustical Society of America.

[9]  Ray Meddis,et al.  Virtual pitch and phase sensitivity of a computer model of the auditory periphery , 1991 .

[10]  G C Galbraith,et al.  Two-channel brain-stem frequency-following responses to pure tone and missing fundamental stimuli. , 1994, Electroencephalography and clinical neurophysiology.

[11]  S Grossberg,et al.  A spectral network model of pitch perception. , 1995, The Journal of the Acoustical Society of America.

[12]  B. Delgutte,et al.  Neural correlates of the pitch of complex tones. II. Pitch shift, pitch ambiguity, phase invariance, pitch circularity, rate pitch, and the dominance region for pitch. , 1996, Journal of neurophysiology.

[13]  B. Delgutte,et al.  Neural correlates of the pitch of complex tones. I. Pitch and pitch salience. , 1996, Journal of neurophysiology.

[14]  Shihab Shamma,et al.  Auditory Representations of Timbre and Pitch , 1996 .

[15]  R. Fay.  Auditory Computation , 1996, Springer Handbook of Auditory Research.

[16]  Ernst Terhardt,et al.  Binaural fusion and the representation of virtual pitch in the human auditory cortex , 1996, Hearing Research.

[17]  C. Pantev,et al.  Tonotopic organization of the sources of human auditory steady-state responses , 1996, Hearing Research.

[18]  P. Heil,et al.  Frequency and periodicity are represented in orthogonal maps in the human auditory cortex: evidence from magnetoencephalography , 1997, Journal of Comparative Physiology A.

[19]  S Makeig,et al.  Blind separation of auditory event-related brain responses into independent components. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[20]  Steven L. Miller,et al.  Language learning impairments: integrating basic science, technology, and remediation , 1998, Experimental Brain Research.

[21]  Alan R. Palmer,et al.  Psychophysical and Physiological Advances in Hearing , 1998 .

[22]  Richard S. J. Frackowiak,et al.  Analysis of temporal structure in sound by the human brain , 1998, Nature Neuroscience.

[23]  F. Ohl,et al.  Right auditory cortex lesion in Mongolian gerbils impairs discrimination of rising and falling frequency-modulated tones , 1998, Neuroscience Letters.

[24]  M. Scherg,et al.  Deconvolution of 40 Hz steady-state fields reveals two overlapping source activities of the human auditory cortex , 1999, Clinical Neurophysiology.

[25]  Aniruddh D. Patel,et al.  Temporal patterns of human cortical activity reflect tone sequence structure , 2000, Nature.

[26]  S Shamma,et al.  The case of the missing pitch templates: how harmonic templates emerge in the early auditory system. , 2000, The Journal of the Acoustical Society of America.

[27]  S. Scott,et al.  Identification of a pathway for intelligible speech in the left temporal lobe. , 2000, Brain : a journal of neurology.

[28]  R. Zatorre,et al.  Functional specificity in the right human auditory cortex for perceiving pitch direction. , 2000, Brain : a journal of neurology.

[29]  T. Picton,et al.  Human auditory steady-state responses to amplitude-modulated tones: phase and latency measurements , 2000, Hearing Research.

[30]  C Pantev,et al.  A high-precision magnetoencephalographic study of human auditory steady-state responses to amplitude-modulated tones. , 2000, The Journal of the Acoustical Society of America.

[31]  R. Patterson,et al.  Encoding of the temporal regularity of sound in the human brainstem , 2001, Nature Neuroscience.