Smoking Is Not a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis in an Australian Population

Background: Controversy persists as to whether smoking is a risk factor for sporadic amyotrophic lateral sclerosis (SALS), the most common form of sporadic motor neuron disease (SMND). We therefore undertook a large case-control study of smoking and SALS in Australia. Methods: Cases and controls were recruited Australia-wide over a 10-year period. SALS and the other subgroups of SMND were categorised on the basis of neurologists’ reports. Controls were partners or friends of SMND patients or community volunteers. Individuals filled in a questionnaire regarding smoking habits. A total of 809 patients with SMND (631 with SALS) and 779 controls were included in the study. SALS males and females were analysed separately. Results: No differences between SALS patients and control groups were found with regard to (1) the odds ratios of ever-smokers, ex-smokers or current smokers compared to never-smokers, (2) the means of numbers of cigarettes per day, years of smoking, pack years or age smoking began or (3) the proportions of their parents who had ever smoked. The proportion of ever-smokers and mean pack years did not differ between the clinical subgroups of SMND or between different sites of SALS onset. Partner smoking did not increase the risk of SMND. Conclusion: This Australian case-control study does not support a link between cigarette smoking and any form of SMND.

[1]  J. Veldink,et al.  Beneficial vascular risk profile is associated with amyotrophic lateral sclerosis , 2011, Journal of Neurology, Neurosurgery & Psychiatry.

[2]  O. Hardiman,et al.  Amyotrophic lateral sclerosis , 2011, The Lancet.

[3]  M. Thun,et al.  Smoking and risk of amyotrophic lateral sclerosis: a pooled analysis of 5 prospective cohorts. , 2011, Archives of neurology.

[4]  M. Hernán,et al.  Smoking and the risk of amyotrophic lateral sclerosis: a systematic review and meta-analysis , 2010, Journal of Neurology, Neurosurgery & Psychiatry.

[5]  R. Pamphlett.  STUDY OF 962 PATIENTS INDICATES PROGRESSIVE MUSCULAR ATROPHY IS A FORM OF ALS , 2010, Neurology.

[6]  V. Sébille,et al.  Rural environment and risk factors of amyotrophic lateral sclerosis: a case–control study , 2010, Journal of Neurology.

[7]  S. Schmidt,et al.  Association of ALS with head injury, cigarette smoking and APOE genotypes , 2010, Journal of the Neurological Sciences.

[8]  A. Reunanen,et al.  Persistent organochlorine pesticides in serum and risk of Parkinson disease , 2010, Neurology.

[9]  M. Hernán,et al.  Association of smoking with amyotrophic lateral sclerosis risk and survival in men and women: a prospective study , 2010, BMC neurology.

[10]  C. Armon.  Smoking may be considered an established risk factor for sporadic ALS , 2009, Neurology.

[11]  H. Mitsumoto,et al.  Study of 962 patients indicates progressive muscular atrophy is a form of ALS , 2009, Neurology.

[12]  S. Sasaki,et al.  Lifestyle factors and risk of amyotrophic lateral sclerosis: a case-control study in Japan. , 2009, Annals of epidemiology.

[13]  F. Clavel-Chapelon,et al.  Smoking and risk for amyotrophic lateral sclerosis: Analysis of the EPIC cohort , 2009, Annals of neurology.

[14]  Honglei Chen,et al.  Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality. , 2009, American journal of epidemiology.

[15]  H. Mattle,et al.  Lifestyle and stroke risk: a review , 2009, Current opinion in neurology.

[16]  M. Desiato,et al.  An exploratory case-control study on spinal and bulbar forms of amyotrophic lateral sclerosis in the province of Rome , 2009, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[17]  S. Pocock,et al.  Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration , 2007, Annals of Internal Medicine [serial online].

[18]  L. H. van den Berg,et al.  Lifetime occupation, education, smoking, and risk of ALS , 2007, Neurology.

[19]  J. Alappat.  ETHNIC VARIATION IN THE INCIDENCE OF ALS: A SYSTEMATIC REVIEW , 2007, Neurology.

[20]  M. Hernán,et al.  Smoking, Snuff Dipping and the Risk of Amyotrophic Lateral Sclerosis – A Prospective Cohort Study , 2006, Neuroepidemiology.

[21]  Robert H. Brown,et al.  Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS) , 2006, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[22]  Philip J. Landrigan,et al.  Early Environmental Origins of Neurodegenerative Disease in Later Life , 2005, Environmental health perspectives.

[23]  M. Thun,et al.  Prospective study of cigarette smoking and amyotrophic lateral sclerosis. , 2004, American journal of epidemiology.

[24]  P. Worms.  The epidemiology of motor neuron diseases: a review of recent studies , 2001, Journal of the Neurological Sciences.

[25]  W. Longstreth,et al.  Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption. , 2000, American journal of epidemiology.

[26]  M. Swash,et al.  El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis , 2000, Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases.

[27]  J. Shefner,et al.  Association of Cigarette Smoking with Amyotrophic Lateral Sclerosis , 1999, Neuroepidemiology.

[28]  M. Vinceti,et al.  Lead, cadmium, and selenium in the blood of patients with sporadic amyotrophic lateral sclerosis , 1997, The Italian Journal of Neurological Sciences.

[29]  R. B. Davies,et al.  MND risk factors: an epidemiological study in the North West of England , 1995, Journal of the Neurological Sciences.

[30]  J. Slattery,et al.  Risk factors for motor neuron disease: a case-control study based on patients from the Scottish Motor Neuron Disease Register. , 1993, Journal of neurology, neurosurgery, and psychiatry.

[31]  M. Carreras,et al.  Motor neuron disease in the province of Ferrara, Italy, in 1964–1982 , 1988, Neurology.

[32]  K. Kondo,et al.  Case-control studies of motor neuron disease: association with mechanical injuries. , 1981, Archives of neurology.

[33]  B. Patten,et al.  Repeat study of antecedent events in motor neuron disease. , 1981, Annals of clinical research.

[34]  A. Ludolph,et al.  Amyotrophic lateral sclerosis. , 2012, Current opinion in neurology.

[35]  S. Pocock,et al.  [The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies]. , 2008, Revista espanola de salud publica.

[36]  G. Savettieri,et al.  A case-control study of amyotrophic lateral sclerosis. , 1991, Neuroepidemiology.

[37]  L. Provinciali,et al.  Antecedent events in amyotrophic lateral sclerosis: do they influence clinical onset and progression? , 1990, Neuroepidemiology.