Hemodynamic Responses to Interictal Epileptiform Discharges in Children with Symptomatic Epilepsy

Purpose: Simultaneous electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) (EEG‐fMRI) recording is a noninvasive tool for investigating epileptogenic networks. Most EEG‐fMRI studies in epilepsy have been performed in adults. Childhood epilepsies, however, differ from those in adults due to interactions between epileptogenic and developmental processes. The purpose of this study was to investigate EEG‐fMRI in children with lesional epilepsies.

[1]  D. Prince,et al.  Cellular and synaptic physiology and epileptogenesis of developing rat neocortical neurons in vitro. , 1987, Brain research.

[2]  J. Burchfiel,et al.  Epileptogenic effect of hypoxia in the immature rodent brain , 1991, Annals of neurology.

[3]  F Andermann,et al.  Focal neuronal migration disorders and intractable partial epilepsy: A study of 30 patients , 1991, Annals of neurology.

[4]  I. Jambaqué,et al.  Visual Inattention in West Syndrome: A Neuropsychological and Neurofunctional Imaging Study , 1993, Epilepsia.

[5]  Frederick Andermann,et al.  Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results , 1995, Annals of neurology.

[6]  G. Holmes.  Epilepsy in the Developing Brain: Lessons from the Laboratory and Clinic , 1997, Epilepsia.

[7]  Louis Lemieux,et al.  Identification of EEG Events in the MR Scanner: The Problem of Pulse Artifact and a Method for Its Subtraction , 1998, NeuroImage.

[8]  Douglas C. Noll,et al.  A Developmental Functional MRI Study of Spatial Working Memory , 1999, NeuroImage.

[9]  M. M. Souweidanea,et al.  Brain Mapping in Sedated Infants and Young Children with Passive-Functional Magnetic Resonance Imaging , 1999 .

[10]  Juergen Hennig,et al.  Visual Processing in Infants and Children Studied Using Functional MRI , 1999, Pediatric Research.

[11]  J. Hirsch,et al.  Surgery of epilepsy associated with focal lesions in childhood. , 1999, Journal of neurosurgery.

[12]  J Hennig,et al.  Effect of pentobarbital on visual processing in man , 2000, Human brain mapping.

[13]  J. Armony,et al.  Auditory Processing across the Sleep-Wake Cycle Simultaneous EEG and fMRI Monitoring in Humans , 2000, Neuron.

[14]  Robert Turner,et al.  A Method for Removing Imaging Artifact from Continuous EEG Recorded during Functional MRI , 2000, NeuroImage.

[15]  G L Shulman,et al.  INAUGURAL ARTICLE by a Recently Elected Academy Member:A default mode of brain function , 2001 .

[16]  E Rostrup,et al.  Visual cortex reactivity in sedated children examined with perfusion MRI (FAIR). , 2002, Magnetic resonance imaging.

[17]  Alan C. Evans,et al.  A General Statistical Analysis for fMRI Data , 2000, NeuroImage.

[18]  Patrick Berg,et al.  Artifact Correction of the Ongoing EEG Using Spatial Filters Based on Artifact and Brain Signal Topographies , 2002, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[19]  Egill Rostrup,et al.  Cortical Deactivation Induced by Visual Stimulation in Human Slow-Wave Sleep , 2002, NeuroImage.

[20]  Peter Stoeter,et al.  EEG‐related Functional MRI in Benign Childhood Epilepsy with Centrotemporal Spikes , 2003, Epilepsia.

[21]  Jean Gotman,et al.  Using patient-specific hemodynamic response functions in combined EEG-fMRI studies in epilepsy , 2003, NeuroImage.

[22]  N. Logothetis.  The Underpinnings of the BOLD Functional Magnetic Resonance Imaging Signal , 2003, The Journal of Neuroscience.

[23]  Ari Syngeniotis,et al.  Benign Epilepsy with Centro‐temporal Spikes: Spike Triggered fMRI Shows Somato‐sensory Cortex Activity , 2003, Epilepsia.

[24]  Jean Gotman,et al.  EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiograms , 2004, Human brain mapping.

[25]  P. Bolton,et al.  The relation of infantile spasms, tubers, and intelligence in tuberous sclerosis complex , 2004, Archives of Disease in Childhood.

[26]  G. Bruce Pike,et al.  Hemodynamic and metabolic responses to neuronal inhibition , 2004, NeuroImage.

[27]  Christian Kaufmann,et al.  Functional MRI during sleep: BOLD signal decreases and their electrophysiological correlates , 2004, The European journal of neuroscience.

[28]  G. Srivastava,et al.  ICA-based procedures for removing ballistocardiogram artifacts from EEG data acquired in the MRI scanner , 2005, NeuroImage.

[29]  David F Abbott,et al.  Cortical/subcortical BOLD changes associated with epileptic discharges , 2005, Neurology.

[30]  J Gotman,et al.  Intrinsic epileptogenicity in polymicrogyric cortex suggested by EEG-fMRI BOLD responses , 2005, Neurology.

[31]  Afonso C. Silva,et al.  Elevated endogenous GABA level correlates with decreased fMRI signals in the rat brain during acute inhibition of GABA transaminase , 2005, Journal of neuroscience research.

[32]  G. Jackson,et al.  Typical childhood absence seizures are associated with thalamic activation. , 2005, Epileptic disorders : international epilepsy journal with videotape.

[33]  J. Gotman,et al.  Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[34]  Emily C. Bell,et al.  Differential effects of chronic lithium and valproate on brain activation in healthy volunteers , 2005, Human psychopharmacology.

[35]  D. Kwiatkowski,et al.  Infantile spasms and intellectual outcomes in children with tuberous sclerosis complex , 2005, Neurology.

[36]  Jean Gotman,et al.  Hemodynamic and metabolic responses to activation, deactivation and epileptic discharges , 2005, NeuroImage.

[37]  J. Gotman,et al.  Cortical and thalamic fMRI responses in partial epilepsy with focal and bilateral synchronous spikes , 2006, Clinical Neurophysiology.

[38]  Jean Gotman,et al.  Negative BOLD responses to epileptic spikes , 2006, Human brain mapping.

[39]  J. Gotman,et al.  Grey matter heterotopia: what EEG-fMRI can tell us about epileptogenicity of neuronal migration disorders. , 2006, Brain : a journal of neurology.

[40]  J. Gotman,et al.  Temporal and Extratemporal BOLD Responses to Temporal Lobe Interictal Spikes , 2006, Epilepsia.

[41]  T. Loenneker,et al.  How depth of anesthesia influences the blood oxygenation level-dependent signal from the visual cortex of children. , 2006, AJNR. American journal of neuroradiology.

[42]  J. Gotman,et al.  Combining EEG and fMRI: A multimodal tool for epilepsy research , 2006, Journal of magnetic resonance imaging : JMRI.

[43]  Jean Gotman,et al.  EEG–fMRI of epileptic spikes: Concordance with EEG source localization and intracranial EEG , 2006, NeuroImage.

[44]  Karl J. Friston,et al.  Hemodynamic correlates of epileptiform discharges: An EEG-fMRI study of 63 patients with focal epilepsy , 2006, Brain Research.