A New Compact Optical System Proposal and Image Quality Comparison Against Other Affordable Non-mydriatic Fundus Cameras

Imaging the eye retina is critical to diagnose various pathologies, particularly Diabetic Retinopathy, which is the leading cause of avoidable blindness in the world. The image acquisition through tabletop fundus cameras is the preferred method for retinopathy screening. However, these devices require expertise for operation, limiting its broad application. In this paper, two handheld fundus camera prototypes developed by Fraunhofer AICOS (EyeFundusScope Compact and EyeFundusScope Standard) have their optical capabilities compared, not only between each other but also with another commercially available camera. Field-of-view measurements are performed, as well as a subjective analysis on eye model images acquired with each of prototypes. Besides the comparison between handheld devices in the same experimental setup, conceptual specification on the prototype and optical system for the Compact version are described in order to demonstrate the most relevant issues to be considered when developing a valuable instrument for diabetic retinopathy screening and diagnosis.

[1]  Luca Giancardo,et al.  Automated fundus images analysis techniques to screen retinal diseases in diabetic patients. (Analyse de "Fundus" image par le diagnostique de la retinopathie diabétique) , 2011 .

[2]  Tomi Kauppi,et al.  Eye Fundus Image Analysis for Automatic Detection of Diabetic Retinopathy , 2010 .

[3]  Mathieu Lamard,et al.  Suitability of a Low-Cost, Handheld, Nonmydriatic Retinograph for Diabetic Retinopathy Diagnosis , 2016, Translational vision science & technology.

[4]  Ramesh Raskar,et al.  eyeSelfie: self directed eye alignment using reciprocal eye box imaging , 2015, ACM Trans. Graph..

[5]  David A. Atchison,et al.  Optics of the Human Eye , 2023 .

[6]  E Peli,et al.  Ophthalmic applications of circular polarizers. , 1986, Journal of the American Optometric Association.

[7]  Richard Wormald,et al.  Leading causes of certification for blindness and partial sight in England & Wales , 2006, BMC public health.

[8]  Pedro Vieira,et al.  Optical Design of a Compact Image Acquisition Device for Mobile Diabetic Retinopathy Screening , 2018, BIODEVICES.

[9]  Larry D Hubbard,et al.  Brightness, contrast, and color balance of digital versus film retinal images in the age-related eye disease study 2. , 2008, Investigative ophthalmology & visual science.

[10]  Francis Arthur Jenkins,et al.  Fundamentals of Optics , 1976 .

[11]  T. Cronin,et al.  The linearly polarized light field in clear, tropical marine waters: spatial and temporal variation of light intensity, degree of polarization and e-vector angle. , 2001, The Journal of experimental biology.

[12]  Valery V Tuchin,et al.  Polarized light interaction with tissues , 2016, Journal of biomedical optics.

[13]  E. Wolf,et al.  Principles of Optics (7th Ed) , 1999 .

[14]  C. Phillips Dilate the pupil and see the fundus. , 1984, British medical journal.

[15]  E. Figueiredo,et al.  Retinal detachment in preeclampsia. , 2002, Arquivos brasileiros de cardiologia.

[16]  A. Witkin,et al.  Imaging in Diabetic Retinopathy , 2015, Middle East African journal of ophthalmology.

[17]  Mohit Chopra,et al.  Pathophysiology of Diabetic Retinopathy , 2013, ISRN ophthalmology.

[18]  J. Cunha-Vaz Characterization and relevance of different diabetic retinopathy phenotypes. , 2007, Developments in ophthalmology.

[19]  I. Deary,et al.  Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures , 2005, Journal of anatomy.

[20]  Kai Jin,et al.  Telemedicine screening of retinal diseases with a handheld portable non-mydriatic fundus camera , 2017, BMC Ophthalmology.

[21]  J. Bueno,et al.  Depolarization effects in the human eye , 2001, Vision Research.

[22]  Shizuo Mukai,et al.  A Portable, Inexpensive, Nonmydriatic Fundus Camera Based on the Raspberry Pi® Computer , 2017, Journal of ophthalmology.

[23]  Kenneth Tran,et al.  Construction of an inexpensive, hand-held fundus camera through modification of a consumer "point-and-shoot" camera. , 2012, Investigative ophthalmology & visual science.

[24]  Jochanan Benbassat,et al.  Objectives of teaching direct ophthalmoscopy to medical students , 2012, Acta ophthalmologica.

[25]  D. Norren,et al.  The Pathways of Light Measured in Fundus Reflectometry , 1996, Vision Research.

[26]  Valérie Biousse,et al.  The Use of Retinal Photography in Nonophthalmic Settings and Its Potential for Neurology , 2012, The neurologist.