Sympathetic ophthalmia. Histopathologic and fluorescein angiographic correlation.

Sympathetic ophthalmia was found 15 months after cataract extraction in a previously traumatized eye. Histopathologic examination disclosed numerous Dalen-Fuchs nodules with underlying choroidal granulomas causing obliteration of the choriocapillaris and disruption of Bruch's membrane. Prominent Dalen-Fuchs nodules were also observed clinically in the sympathizing eye, and the angiographic findings of initial hypofluorescence followed by late hyperfluorescence correlated with the pathologic findings in the sympathogenic eye. Only ten cases of sympathetic ophthalmia with fluorescein angiography have been reported previously. This is the fifth case accompanied by a histopathologic description of the exciting eye. The finding of breaks in Bruch's membrane has not been previously reported, to the best of our knowledge. This article compares the angiographic and pathologic appearances with those described in previous reports.

[1]  B. S. Fine,et al.  Light and electron microscopic study of Dalén-Fuchs nodules in sympathetic ophthalmia. , 1983, Ophthalmology.

[2]  C. Marboe,et al.  Human sympathetic ophthalmia. An analysis of the inflammatory infiltrate by hybridoma-monoclonal antibodies, immunochemistry, and correlative electron microscopy. , 1983, Ophthalmology.

[3]  D. Albert,et al.  Sixty-five years of sympathetic ophthalmia. A clinicopathologic review of 105 cases (1913--1978). , 1980, Ophthalmology.

[4]  G. E. Marak.  Recent advances in sympathetic ophthalmia. , 1979, Survey of ophthalmology.

[5]  W. Spencer,et al.  Sympathetic uveitis after trauma and vitrectomy. , 1978, Archives of ophthalmology.

[6]  M. Spitznas.  [Fluorescein angiographic picture of sympathetic ophthalmia (author's transl)]. , 1976, Klinische Monatsblatter fur Augenheilkunde.

[7]  Yoshiharu Kobayashi,et al.  Inflammations of the Choroid , 1976 .

[8]  J. Gass.  Correlation of Fluorescein Angiography and Histopathology , 1976 .

[9]  T. Ishikawa.  The fine structure of the Dalen-Fuch snodule in sympathetic ophthalmia -1-Changes of the pigment epithelial cells within the Dalen-Fuchsnodule , 1972 .

[10]  K. Segawa.  Sympathetic ophthalmia;A comparative fluorographic and electronmicroscopic study , 1971 .

[11]  J. Gass.  Acute posterior multifocal placoid pigment epitheliopathy. , 1968, Archives of ophthalmology.

[12]  K. Niimi,et al.  [Fluorescein fundus photography and spectral reflectance photography in case of Harada's disease and sympathetic ophthalmia]. , 1968, Nihon ganka kiyo.

[13]  S. Duke-Elder,et al.  Diseases of the uveal tract , 1966 .

[14]  L. Zimmerman,et al.  SYMPATHETIC OPHTHALMIA AND BILATERAL PHACOANAPHYLAXIS. A CLINICOPATHOLOGIC CORRELATION OF THE SYMPATHOGENIC AND SYMPATHIZING EYES. , 1964, Archives of ophthalmology.