Synthesis of N-substituted benzo[c][1,7]- and benzo[c][1,8] phenanthrolin-(5H)-6-ones through a Pd-mediated Suzuki–Miyaura heteroaryl-aryl coupling reaction

[1]  Y. Pommier DNA topoisomerase I inhibitors: chemistry, biology, and interfacial inhibition. , 2009, Chemical reviews.

[2]  C. So,et al.  Palladium-indolylphosphine-catalyzed Hiyama cross-coupling of aryl mesylates. , 2009, Organic letters.

[3]  V. Bourgarel-Rey,et al.  Cascade synthesis of polyoxygenated 6H,11H-[2]benzopyrano-[4,3-c][1]benzopyran-11-ones. , 2007, The Journal of organic chemistry.

[4]  Y. Pommier Topoisomerase I inhibitors: camptothecins and beyond , 2006, Nature Reviews Cancer.

[5]  Soizic Prado,et al.  Synthesis of benzo[c][1,8]phenanthrolin-6-one through cyclization of N-(isoquinol-5-yl)-2-bromo-benzamide derivatives , 2006 .

[6]  D. Tanner,et al.  Comparative study of the Kumada, Negishi, Stille, and Suzuki-Miyaura reactions in the synthesis of the indole alkaloids hippadine and pratosine. , 2006, The Journal of organic chemistry.

[7]  E. LaVoie,et al.  Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents. , 2005, Bioorganic & Medicinal Chemistry.

[8]  Y. Pommier,et al.  Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings. , 2004, Journal of medicinal chemistry.

[9]  R. Mailman,et al.  Synthesis and SAR exploration of dinapsoline analogues. , 2004, Bioorganic & medicinal chemistry.

[10]  Peter J Houghton,et al.  Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. , 2003, Cancer research.

[11]  Sambasivarao Kotha,et al.  Recent applications of the Suzuki–Miyaura cross-coupling reaction in organic synthesis , 2002 .

[12]  A. Ray,et al.  Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. , 2002, Bioorganic & medicinal chemistry letters.

[13]  J. Zhang,et al.  Synthesis of substituted 5[H]phenanthridin-6-ones as potent poly(ADP-ribose)polymerase-1 (PARP1) inhibitors. , 2001, Bioorganic & medicinal chemistry letters.

[14]  Watanabe,et al.  Palladium-catalyzed borylation of aryl halides or triflates with dialkoxyborane: A novel and facile synthetic route to arylboronates , 2000, The Journal of organic chemistry.

[15]  A. Mckillop,et al.  A versatile synthesis of fully aromatic benzo[c]phenanthridine alkaloids , 1998 .

[16]  C. Cadilhac,et al.  Convenient synthesis of aromatic thiols from phenols , 1996 .

[17]  Norio Miyaura,et al.  Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds , 1995 .

[18]  C. Ling,et al.  MODELS FOR INTRAMOLECULAR EXCHANGE IN ORGANIC PI -CONJUGATED OPEN-SHELL SYSTEMS : 3-NITRENOPHENYL AND 4-NITRENOPHENYL UNITS CONNECTED BY 2,5-FURANDIYL , 2,5-THIOPHENEDIYL, AND 2,5-PYRROLEDIYL NONALTERNANT EXCHANGE LINKERS , 1994 .

[19]  M. Banwell,et al.  Convergent Routes to the [1,3]Dioxolo[4,5-j]phenanthridin-6(5H)-one and 2,3,4,4a-Tetrahydro[1,3]dioxolo[4,5-j]phenanthridin-6(5H)-one Nuclei. Application to Syntheses of the Amaryllidaceae Alkaloids Crinasiadine, N-Methylcrinasiadine and Trisphaeridine , 1994 .

[20]  J. Riou,et al.  Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives. , 1993, Journal of medicinal chemistry.

[21]  S. Gronowitz,et al.  The first synthesis of thieno[c]isoquinolines and an improved synthesis of phenanthridine and thieno[c]quinolines through pd(0) catalyzed coupling of ortho‐formylarylboronic acids with functionalized aryl halides , 1989 .

[22]  V. Snieckus,et al.  The directed metalation connection to aryl-aryl cross coupling.Regiospecific synthesis of phenanthridines, phenanthridinones and the biphenyl alkaloid ismine , 1988 .

[23]  A. Echavarren,et al.  Palladium-catalyzed coupling of aryl triflates with organostannanes , 1987 .

[24]  A. Sekiguchi,et al.  Germathiirane intermediate from the reaction of germylene with thioketones , 1985 .

[25]  R. Miller,et al.  Synthesis of isoquinolines from indenes , 1980 .

[26]  W. E. Cass,et al.  Derivatives of Aminoisoquinolines1 , 1942 .