Experience with autologous bone marrow harvesting and transfusion of marrow‐derived red cells

Marrow red cells (MRBCs) from 56 autologous bone marrow harvests were rescued after processing and transfused as the sole transfusion support after surgery. There was no correlation between volume of harvest and total mononuclear cell (MNC) count. The marrow collection induced a significant decrease in hematocrit values (mean, 6.1; range, ‐0.3‐12.3; p less than 0.001) unrelated to the patient's diagnosis, age, or gender. Processing of the marrows resulted in a mean transfused MRBC mass of 258 mL (range, 101–494 mL), representing 78 percent (range, 43‐ 100%) of the MRBC mass collected. The amount of MRBCs transfused correlated with total MNC count (p less than 0.01). All autologous MRBC transfusions were well tolerated. It can be concluded that autologous MRBC transfusions are safe and may eliminate the need for homologous blood transfusions after marrow harvest.

[1]  P. Sonneveld,et al.  Transfusion of red cells after autologous bone marrow harvest in patients with acute leukemia and malignant lymphoma , 1990, Transfusion.

[2]  C Chuang-Stein,et al.  The relationship of blood transfusion, tumor staging, and cancer recurrence , 1990, Transfusion.

[3]  G. Meloni,et al.  Autologous bone marrow transplantation for acute myelocytic leukemia in first remission: a European survey of the role of marrow purging. , 1990, Blood.

[4]  K. Sullivan,et al.  Autologous marrow transplantation for malignant lymphoma: a report of 101 cases from Seattle. , 1990, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[5]  D. Burke,et al.  Direct measurement of human immunodeficiency virus seroconversions in a serially tested population of young adults in the United States Army, October 1985 to October 1987. Walter Reed Retrovirus Research Group. , 1989, The New England journal of medicine.

[6]  M. Cairo,et al.  Clinical and laboratory experience in marrow harvesting in children for autologous bone marrow transplantation. , 1989, Bone Marrow Transplantation.

[7]  R. Shadduck,et al.  Transfusion of bone marrow red cells during bone marrow harvests. , 1988, Experimental Hematology.

[8]  R. Gale,et al.  Advanced breast cancer: high-dose chemotherapy and bone marrow autotransplants. , 1988, Annals of internal medicine.

[9]  J. Armitage,et al.  Harvesting marrow for autologous transplantation from patients with malignancies. , 1987, Bone marrow transplantation.

[10]  E. Thomas,et al.  Experience with marrow harvesting from donors less than two years of age. , 1987, Bone marrow transplantation.

[11]  J. Thompson,et al.  Prolongation of survival for high-grade malignant gliomas with adjuvant high-dose BCNU and autologous bone marrow transplantation. , 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  W. Sherwood,et al.  A review of recent events related to surrogate testing of blood to prevent non‐A, non‐B posttransfusion hepatitis , 1987, Transfusion.

[13]  J. McCullough,et al.  Use of blood components containing red cells by donors of allogeneic bone marrow , 1986, Transfusion.

[14]  F. Appelbaum,et al.  Marrow harvesting for autologous marrow transplantation. , 1985, Experimental hematology.