The Emergence of Systematic Review in Toxicology

The Evidence-based Toxicology Collaboration hosted a workshop on “The Emergence of Systematic Review and Related Evidence-based Approaches in Toxicology,” on November 21, 2014 in Baltimore, Maryland. The workshop featured speakers from agencies and organizations applying systematic review approaches to questions in toxicology, speakers with experience in conducting systematic reviews in medicine and healthcare, and stakeholders in industry, government, academia, and non-governmental organizations. Based on the workshop presentations and discussion, here we address the state of systematic review methods in toxicology, historical antecedents in both medicine and toxicology, challenges to the translation of systematic review from medicine to toxicology, and thoughts on the way forward. We conclude with a recommendation that as various agencies and organizations adapt systematic review methods, they continue to work together to ensure that there is a harmonized process for how the basic elements of systematic review methods are applied in toxicology.

[1]  Sebastian Hoffmann,et al.  Evidence-based toxicology for the 21st century: opportunities and challenges. , 2013, ALTEX.

[2]  Trisha Greenhalgh,et al.  How to read a paper: Papers that summarise other papers (systematic reviews and meta-analyses) , 1997 .

[3]  J. Higgins.  Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [updated March 2011]. The Cochrane Collaboration , 2011 .

[4]  L. Hartling,et al.  Assessing Risk of Bias and Confounding in Observational Studies of Interventions or Exposures: Further Development of the RTI Item Bank , 2013 .

[5]  E. Guallar,et al.  Bone Lead Levels and Blood Pressure Endpoints: A Meta-Analysis , 2008, Epidemiology.

[6]  T. Greenhalgh,et al.  Papers that summarise other papers (systematic reviews and meta-analyses). , 1997, BMJ.

[7]  Paula I. Johnson,et al.  The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Nonhuman Evidence for PFOA Effects on Fetal Growth , 2014, Environmental health perspectives.

[8]  T. Hartung.  Evidence-based toxicology - the toolbox of validation for the 21st century? , 2010, ALTEX.

[9]  A. Sharrett,et al.  Arsenic exposure and cardiovascular disease: a systematic review of the epidemiologic evidence. , 2005, American journal of epidemiology.

[10]  G. Guyatt,et al.  GRADE: an emerging consensus on rating quality of evidence and strength of recommendations , 2008, BMJ : British Medical Journal.

[11]  Gerald Gartlehner,et al.  [GRADE guidelines: 1. Introduction - GRADE evidence profiles and summary of findings tables]. , 2012, Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen.

[12]  M. Stephens,et al.  The Usefulness of Systematic Reviews of Animal Experiments for the Design of Preclinical and Clinical Studies , 2014, ILAR journal.

[13]  Ellen Silbergeld,et al.  Evidence-based toxicology: strait is the gate, but the road is worth taking. , 2013, ALTEX.

[14]  D. Moher,et al.  Scoping reviews: time for clarity in definition, methods, and reporting. , 2014, Journal of clinical epidemiology.

[15]  Gábor L. Lövei,et al.  Implementation of systematic reviews in EFSA scientific outputs workflow , 2012 .

[16]  T. Woodruff,et al.  Instruments for Assessing Risk of Bias and Other Methodological Criteria of Published Animal Studies: A Systematic Review , 2013, Environmental health perspectives.

[17]  Laura A. Levit,et al.  Finding what works in health care : standards for systematic reviews , 2011 .

[18]  Martin Stephens,et al.  Mechanistic validation. , 2013, ALTEX.

[19]  Roger M. Cooke,et al.  TU Delft expert judgment data base , 2008, Reliab. Eng. Syst. Saf..

[20]  Steven Chang.  Systematic review workshop materials , 2018 .

[21]  Thomas Hartung,et al.  Perspectives on validation of high-throughput assays supporting 21st century toxicity testing. , 2013, ALTEX.

[22]  T Hartung,et al.  Toward an evidence-based toxicology , 2006, Human & experimental toxicology.

[23]  Patrice Sutton,et al.  An evidence-based medicine methodology to bridge the gap between clinical and environmental health sciences. , 2011, Health affairs.

[24]  D. Sackett,et al.  Evidence based medicine: what it is and what it isn't , 1996, BMJ.

[25]  Division on Earth.  Review of Epa's Integrated Risk Information System (Iris) Process , 2014 .

[26]  Thomas Hartung,et al.  "ToxRTool", a new tool to assess the reliability of toxicological data. , 2009, Toxicology letters.

[27]  Paula I. Johnson,et al.  The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Integration of Animal and Human Evidence for PFOA Effects on Fetal Growth , 2014, Environmental health perspectives.

[28]  John R. Bucher,et al.  Systematic Review and Evidence Integration for Literature-Based Environmental Health Science Assessments , 2014, Environmental health perspectives.

[29]  Sebastian Hoffmann,et al.  Guidance on assessing the methodological and reporting quality of toxicologically relevant studies: A scoping review. , 2016, Environment international.

[30]  E. Guallar,et al.  Arsenic Exposure and Type 2 Diabetes: A Systematic Review of the Experimental and Epidemiologic Evidence , 2005, Environmental health perspectives.

[31]  Tracey J. Woodruff,et al.  The Navigation Guide Systematic Review Methodology: A Rigorous and Transparent Method for Translating Environmental Health Science into Better Health Outcomes , 2014, Environmental health perspectives.

[32]  Sebastian Hoffmann,et al.  Diagnosis: toxic!--trying to apply approaches of clinical diagnostics and prevalence in toxicology considerations. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[33]  Max Henrion,et al.  Uncertainty: A Guide to Dealing with Uncertainty in Quantitative Risk and Policy Analysis , 1990 .

[34]  Wim De Coen,et al.  Development of a screening assay to identify teratogenic and embryotoxic chemicals using the zebrafish embryo. , 2009, Reproductive toxicology.

[35]  T. Hartung,et al.  WBI Studies Repository WBI Studies Repository Food for Thought … Mechanistic Validation Food for Thought … Mechanistic Validation , 2013 .

[36]  Tracey J. Woodruff,et al.  The Navigation Guide—Evidence-Based Medicine Meets Environmental Health: Systematic Review of Human Evidence for PFOA Effects on Fetal Growth , 2014, Environmental health perspectives.

[37]  D. Blacker.  Food for thought. , 2013, JAMA neurology.

[38]  Michael S Victoroff,et al.  Evidence-based toxicology: a comprehensive framework for causation , 2005, Human & experimental toxicology.

[39]  Gábor L. Lövei,et al.  Application of Systematic Review Methodology to Food and Feed Safety Assessments to Support Decision Making , 2010 .

[40]  U. Tillmann,et al.  A systematic approach for evaluating the quality of experimental toxicological and ecotoxicological data. , 1997, Regulatory toxicology and pharmacology : RTP.