Fibrinolytic Activity in Rat Anaphylaxis

Summary The activity of fibrinolytic system measured by different methods and the concentration of plasma fibrinogen were determined in rats suffering mild or severe active anaphylactic shock. In severe anaphylactic shock of Bordetella Pertussis Vaccine pretreated animals, the plasminogen activator content was markedly enhanced and the fibrinolytic activity significantly increased; however, the total inhibitor capacity did not change. The fall in fibrinogen concentration was only moderate. Similar but minor enhancement of fibrinolysis could be observed in mild anaphylaxis. The results suggest that the activated plasminogen-plasmin system may contribute to the development of severe anaphylactic outcome in the rat. The possible pathogenic mode is discussed.

[1]  R. Colman,et al.  Origin of the high molecular weight activator of prekallikrein. , 1973, The Journal of biological chemistry.

[2]  S. Niewiarowski,et al.  Plasmin-induced platelet aggregation and platelet release reaction. Effects on hemostasis. , 1973, The Journal of clinical investigation.

[3]  J. Shainoff,et al.  Fate of fibrinopeptides in the reaction between human plasmin and fibrinogen. , 1973, Biochimica et biophysica acta.

[4]  T. Yasukouchi,et al.  A New Method Based on One Dimensional Diffusion Using Small Glass Tubes for the Measurement of Fibrinolytic Activity , 1972, Thrombosis and Haemostasis.

[5]  L. Muszbek,et al.  THE EFFECT OF BORDETELLA PERTUSSIS VACCINE ON PROTEASE SENSITIVITY AND ON THE ANAPHYLACTIC PROTEASE PRODUCTION IN RATS , 1972, Acta allergologica.

[6]  R. Biggs.  Human blood coagulation, haemostasis and thrombosis; , 1972 .

[7]  M. Małofiejew.  The biological and pharmacological properties of some fibrinogen degradation products. , 1971, Scandinavian journal of haematology. Supplementum.

[8]  H. Tyler,et al.  The Measurement of Fibrinolysis in the Rat , 1971, Thrombosis and Haemostasis.

[9]  K. Kovács,et al.  THE EFFECT OF ADRENALECTOMY ON PROTEASE SENSITIVITY AND ANAPHYLACTIC PROTEASE PRODUCTION IN THE RAT , 1971, Acta allergologica.

[10]  B. Csaba,et al.  The effect of temperature and some mediator antagonists on anaphylactic shock in mice. , 1971, International archives of allergy and applied immunology.

[11]  G. Grannis.  Plasma fibrinogen: determination, normal values, physiopathologic shifts, and fluctuations. , 1970, Clinical chemistry.

[12]  W. Vogt,et al.  Plasma Kininogenases and Their Activators , 1970 .

[13]  M. Gallimore,et al.  The Influence of Various Plasma Components on the Lysis of Dilute Human Blood Clots , 1969, Thrombosis and Haemostasis.

[14]  K. Buluk,et al.  The pharmacological properties of fibrinogen degradation products , 1969, British journal of pharmacology.

[15]  O. Ratnoff.  Some relationships among hemostasis, fibrinolytic phenomena, immunity, and the inflammatory response. , 1969, Advances in immunology.

[16]  V. Donaldson.  C′l activation in hereditary angioneurotic edema plasma: role of urokinase and inhibitors , 1968 .

[17]  N. Back,et al.  PROTEINASES and PROTEINASE INHIBITORS IN EXPERIMENTAL SHOCK STATES * , 1968, Annals of the New York Academy of Sciences.

[18]  G. B. West,et al.  The effect of temperature and some antagonistic drugs on anaphylactic shock in the rat. , 1968, International archives of allergy and applied immunology.

[19]  G. B. West,et al.  Inhibition of anaphylactic shock in the rat by antihistamines and ascorbic acid. , 1966, British journal of pharmacology and chemotherapy.

[20]  G. B. West,et al.  The importance of bradykinin in anaphylactic shock , 1965, The Journal of pharmacy and pharmacology.

[21]  A. Munson,et al.  ON THE RELATIONSHIP BETWEEN PLASMIN AND KININ * , 1963, Annals of the New York Academy of Sciences.

[22]  W. Krivit,et al.  Study of fibrinogen and plasminogen concentrations in rabbits during anaphylactic shock. , 1961, The Journal of laboratory and clinical medicine.

[23]  B. Zweifach,et al.  SOME EFFECTS OF PROTEOLYTIC INHIBITORS ON TISSUE INJURY AND SYSTEMIC ANAPHYLAXIS , 1961, The Journal of experimental medicine.

[24]  G. B. West,et al.  Anaphylactic shock in the albino rat , 1958, The Journal of physiology.

[25]  O. Ratnoff,et al.  STUDIES ON THE ACTIVATION OF A PROESTERASE ASSOCIATED WITH PARTIALLY PURIFIED FIRST COMPONENT OF HUMAN COMPLEMENT , 1958, The Journal of experimental medicine.

[26]  G. Ungar,et al.  ACTIVATION OF PROFIBRINOLYSIN BY ANTIGEN-ANTIBODY REACTION AND BY ANAPHYLACTOID AGENTS; ITS RELATION TO COMPLEMENT , 1953, The Journal of experimental medicine.

[27]  W. Stinebring,et al.  STUDIES ON THE ACTIVATION OF SERUM PROTEASE BY AN ANTIGEN-ANTIBODY SYSTEM , 1953, The Journal of experimental medicine.

[28]  S. Malkiel,et al.  Histamine Sensitivity and Anaphylaxis in the Pertussis-Vaccinated Rat.∗ , 1952, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[29]  G. Ungar,et al.  OBSERVATIONS ON THE RELEASE OF SERUM FIBRINOLYSIN BY SPECIFIC ANTIGEN, PEPTONE, AND CERTAIN POLYSACCHARIDES , 1949, The Journal of experimental medicine.

[30]  R. G. Macfarlane,et al.  Fibrinolysis; its mechanism and significance. , 1948, Blood.

[31]  S. O. Andrade,et al.  Fibrinolysis in Peptone and Anaphylactic Shock in the Dog , 1946, Nature.