Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia

[1]  S. Pyne,et al.  Role of sphingosine kinases and lipid phosphate phosphatases in regulating spatial sphingosine 1-phosphate signalling in health and disease. , 2009, Cellular signalling.

[2]  T. Okada,et al.  Sphingosine kinase/sphingosine 1-phosphate signalling in central nervous system. , 2009, Cellular signalling.

[3]  T. Ohmori,et al.  Antagonism of Sphingosine 1-Phosphate Receptor-2 Enhances Migration of Neural Progenitor Cells Toward an Area of Brain Infarction , 2008, Stroke.

[4]  M. Tansey,et al.  Journal of Neuroinflammation BioMed Central Review , 2008 .

[5]  S. Milstien,et al.  Regulation and functions of sphingosine kinases in the brain. , 2008, Biochimica et biophysica acta.

[6]  S. Milstien,et al.  Apoptosis induces expression of sphingosine kinase 1 to release sphingosine‐1‐phosphate as a “come‐and‐get‐me” signal , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[7]  L. Obeid,et al.  Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. , 2008, Prostaglandins & other lipid mediators.

[8]  A. Melendez.  Sphingosine kinase signalling in immune cells: potential as novel therapeutic targets. , 2008, Biochimica et biophysica acta.

[9]  Y. Zhuang,et al.  Suppression of Ulcerative Colitis in Mice by Orally Available Inhibitors of Sphingosine Kinase , 2008, Digestive Diseases and Sciences.

[10]  R. Woltjer,et al.  Manipulation of microglial activation as a therapeutic strategy in Alzheimer's disease. , 2007, Current medicinal chemistry.

[11]  S. Milstien,et al.  Autocrine and paracrine roles of sphingosine-1-phosphate , 2007, Trends in Endocrinology & Metabolism.

[12]  W. Robberecht,et al.  Microglia in amyotrophic lateral sclerosis. , 2007, Acta neurologica Belgica.

[13]  E. Ling,et al.  Microglial activation and its implications in the brain diseases. , 2007, Current medicinal chemistry.

[14]  M. ter Braak,et al.  Regulation and functional roles of sphingosine kinases , 2007, Naunyn-Schmiedeberg's Archives of Pharmacology.

[15]  B. Wattenberg,et al.  The sphingosine and diacylglycerol kinase superfamily of signaling kinases: localization as a key to signaling function Published, JLR Papers in Press, March 6, 2006. , 2006, Journal of Lipid Research.

[16]  P. Peterson,et al.  Microglia as a Pharmacological Target in Infectious and Inflammatory Diseases of the Brain , 2006, Journal of Neuroimmune Pharmacology.

[17]  R. Proia,et al.  IgE-dependent Activation of Sphingosine Kinases 1 and 2 and Secretion of Sphingosine 1-Phosphate Requires Fyn Kinase and Contributes to Mast Cell Responses* , 2006, Journal of Biological Chemistry.

[18]  E. Goetzl,et al.  Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network , 2005, Nature Reviews Immunology.

[19]  S. Payne,et al.  Expression of SphK1 impairs degranulation and motility of RBL-2H3 mast cells by desensitizing S1P receptors. , 2005, Blood.

[20]  M. Block,et al.  Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism , 2005, Progress in Neurobiology.

[21]  S. T. Dheen,et al.  Retinoic acid inhibits expression of TNF‐α and iNOS in activated rat microglia , 2005 .

[22]  A. Olivera,et al.  Sphingolipids and the Balancing of Immune Cell Function: Lessons from the Mast Cell , 2005, The Journal of Immunology.

[23]  F. Vilhardt.  Microglia: phagocyte and glia cell. , 2005, The international journal of biochemistry & cell biology.

[24]  A. Melendez,et al.  Anaphylatoxin Signaling in Human Neutrophils , 2004, Journal of Biological Chemistry.

[25]  J. Chun,et al.  Lysophospholipid G Protein-coupled Receptors* , 2004, Journal of Biological Chemistry.

[26]  T. Hla,et al.  Point-Counterpoint of Sphingosine 1-Phosphate Metabolism , 2004, Circulation research.

[27]  T. Rao,et al.  Microglial activation state and lysophospholipid acid receptor expression , 2003, International Journal of Developmental Neuroscience.

[28]  S. Rivest,et al.  Glucocorticoids Play a Fundamental Role in Protecting the Brain during Innate Immune Response , 2003, The Journal of Neuroscience.

[29]  T. Hla,et al.  Sphingosine-1-phosphate signaling in endothelial activation. , 2003, Journal of atherosclerosis and thrombosis.

[30]  Sarah Spiegel,et al.  Sphingosine-1-phosphate: an enigmatic signalling lipid , 2003, Nature Reviews Molecular Cell Biology.

[31]  S. Rivest,et al.  Endotoxemia Prevents the Cerebral Inflammatory Wave Induced by Intraparenchymal Lipopolysaccharide Injection: Role of Glucocorticoids and CD141 , 2002, The Journal of Immunology.

[32]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[33]  N. Rothwell,et al.  Cytokines and acute neurodegeneration , 2001, Nature Reviews Neuroscience.

[34]  A. Hao,et al.  Origin of microglia , 2001, Microscopy research and technique.

[35]  G. Landreth,et al.  β-Amyloid Stimulation of Microglia and Monocytes Results in TNFα-Dependent Expression of Inducible Nitric Oxide Synthase and Neuronal Apoptosis , 2001, The Journal of Neuroscience.

[36]  A. Hara,et al.  Tumor necrosis factor-α-mediated signal transduction in human neutrophils: Involvement of sphingomyelin metabolites in the priming effect of tnf-α on the fMLP-stimulated superoxide production , 1999 .

[37]  W. Streit,et al.  Reactive microgliosis , 1999, Progress in Neurobiology.

[38]  H. Kettenmann,et al.  An immortalized cell line expresses properties of activated microglial cells , 1992, Journal of neuroscience research.