In Vivo Validation of Volume Flow Measurements of Pulsatile Flow Using a Clinical Ultrasound System and Matrix Array Transducer.

The goal of this study was to evaluate the accuracy of a non-invasive C-plane Doppler estimation of pulsatile blood flow in the lower abdominal vessels of a porcine model. Doppler ultrasound measurements from a matrix array transducer system were compared with invasive volume flow measurements made on the same vessels with a surgically implanted ultrasonic transit-time flow probe. For volume flow rates ranging from 60 to 750 mL/min, agreement was very good, with a Pearson correlation coefficient of 0.97 (p < 0.0001) and a mean bias of -4.2%. The combination of 2-D matrix array technology and fast processing gives this Doppler method clinical potential, as many of the user- and system-dependent parameters of previous methods, including explicit vessel angle and diameter measurements, are eliminated.

[1]  C. McArdle,et al.  Potential role of doppler perfusion index in selection of patients with colorectal cancer for adjuvant chemotherapy , 2000, The Lancet.

[2]  R. Gill.  Pulsed Doppler with B-mode imaging for quantitative blood flow measurement. , 1979, Ultrasound in medicine & biology.

[3]  H. Torp,et al.  Volumetric blood flow measurement with the use of dynamic 3-dimensional ultrasound color flow imaging. , 2000, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[4]  P. Virkkunen,et al.  Reproducibility of Doppler Ultrasound Measurements , 1996, Acta radiologica.

[5]  K. Thiele,et al.  Accuracy of real-time, three-dimensional Doppler echocardiography for stroke volume estimation compared with phase-encoded MRI: an in vivo study , 2008, Heart.

[6]  M. Y. Park,et al.  Effect of beam-flow angle on velocity measurements in modern Doppler ultrasound systems. , 2012, AJR. American journal of roentgenology.

[7]  K. Thiele,et al.  The use of live three-dimensional Doppler echocardiography in the measurement of cardiac output: an in vivo animal study. , 2005, Journal of the American College of Cardiology.

[8]  P. Burns.  Measuring volume flow with Doppler ultrasound—an old nut , 1992, Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.

[9]  J D Meindl,et al.  Blood flow measurement using the attenuation-compensated volume flowmeter. , 1979, Ultrasonic imaging.

[10]  P. Burns,et al.  The attenuation compensated C-mode flowmeter: a new Doppler method for blood volume flow measurement , 1997, 1997 IEEE Ultrasonics Symposium Proceedings. An International Symposium (Cat. No.97CH36118).

[11]  J. Rubin,et al.  Three‐Dimensional Sonographic Measurement of Blood Volume Flow in the Umbilical Cord , 2012, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[12]  O. Bonnefous,et al.  Time Domain Formulation of Pulse-Doppler Ultrasound and Blood Velocity Estimation by Cross Correlation , 1986, Ultrasonic imaging.

[13]  P. Virkkunen,et al.  Reliability of doppler ultrasound in follow-up studies , 1998, Acta radiologica.

[14]  Karl Thiele,et al.  A novel method for the assessment of the accuracy of computing laminar flow stroke volumes using a real-time 3D ultrasound system: In vitro studies. , 2005, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[15]  J. Rubin,et al.  Measurement of Volumetric Flow , 2006, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

[16]  P. Ask,et al.  Estimation of volume flow rate by surface integration of velocity vectors from color Doppler images. , 1995, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[17]  D. Steinman,et al.  Effect of velocity profile skewing on blood velocity and volume flow waveforms derived from maximum Doppler spectral velocity. , 2013, Ultrasound in medicine & biology.

[18]  M. Brandestini.  Topoflow - A digital full range Doppler velocity meter , 1978 .

[19]  E. Leen,et al.  Hepatic Blood Flow Changes in Chronic Hepatitis C Measured by Duplex Doppler Color Sonography: Relationship to Histological Features , 1998, Digestive Diseases and Sciences.

[20]  W. Kim,et al.  A new Doppler method for quantification of volumetric flow: in vivo validation using color Doppler. , 1996, Journal of the American College of Cardiology.

[21]  J. Whitworth,et al.  Validation of transonic small animal flowmeter for measurement of cardiac output and regional blood flow in the rat. , 1996, Journal of cardiovascular pharmacology.

[22]  Xiaokui Li,et al.  Real-time 3-dimensional Doppler echocardiography for the assessment of stroke volume: an in vivo human study compared with standard 2-dimensional echocardiography. , 2005, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

[23]  D. Sahn,et al.  Surface integration of velocity vectors from 3D digital colour Doppler: an angle independent method for laminar flow measurements. , 2002, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology.

[24]  H. Spotnitz,et al.  Validation study of a new transit time ultrasonic flow probe for continuous great vessel measurements. , 1996, ASAIO journal.

[25]  P. Embree,et al.  The Accurate Ultrasonic Measurement of the Volume Flow of Blood by Time Domain Correlation , 1985, IEEE 1985 Ultrasonics Symposium.

[26]  R. Gill.  Measurement of blood flow by ultrasound: accuracy and sources of error. , 1985, Ultrasound in medicine & biology.