Relapse in major depressive disorder: analysis with the life table.

With the use of life tables to describe time while patients were well and subsequent rates of relapse for 75 patients after their recovery from an episodes of major depressive disorder in naturalistic study, a high risk of relapse was detected shortly after recovery. Twenty-four percent of patients relapsed within 12 weeks at risk, and 12% of patients relapsed with four weeks at risk. The presence of an underlying chronic depression and three or more previous affective episodes predicted a statistically significant increase in the rate of relapse. These data were used to develop an exponential model of relapse probability for a subgroup of the study population.

[1]  M. Keller,et al.  "Double depression": superimposition of acute depressive episodes on chronic depressive disorders. , 1982, The American journal of psychiatry.

[2]  W. Haenszel,et al.  Statistical aspects of the analysis of data from retrospective studies of disease. , 1959, Journal of the National Cancer Institute.

[3]  J. Fleiss,et al.  Hamilton Depression Rating Scale. Extracted from Regular and Change Versions of the Schedule for Affective Disorders and Schizophrenia. , 1981, Archives of general psychiatry.

[4]  P. Grof,et al.  Lithium Drop-Outs A Follow-Up Study of Patients who Discontinued Prophylactic Treatment , 1970 .

[5]  E. Kaplan,et al.  Nonparametric Estimation from Incomplete Observations , 1958 .

[6]  M. Shepherd,et al.  Continuation therapy with tricyclic antidepressants in depressive illness. , 1972, Lancet.

[7]  J. Fleiss,et al.  Actuarial studies of the course of manic-depressive illness. , 1978, Comprehensive psychiatry.

[8]  M. Weissman,et al.  Application of life table method to naturalistic designs--a comparison of efficacy of tricyclic antidepressants and benzodiazepines in ambulatory depressives. , 1978, Comprehensive psychiatry.

[9]  Emil Kraepelin,et al.  Manic-depressive insanity and paranoia , 1976 .

[10]  E. Robins,et al.  Research diagnostic criteria: rationale and reliability. , 1978, Archives of general psychiatry.

[11]  F K Goodwin,et al.  Major affective disorder as a recurrent illness: a critical review. , 1979, Archives of general psychiatry.

[12]  M. Shepherd,et al.  An evaluation of continuation therapy with tricyclic antidepressants in depressive illness , 1973, Psychological Medicine.

[13]  G. Klerman,et al.  Treatment of depression by drugs and psychotherapy. , 1974, The American journal of psychiatry.

[14]  M. Keller,et al.  Major Depressive Disorder: Initial Results from a One‐Year Prospective Naturalistic Follow‐Up Study , 1981, The Journal of nervous and mental disease.

[15]  M. Keller,et al.  Initial 6-month follow-up of patients with major depressive disorder. A preliminary report from the NIMH collaborative study of the psychobiology of depression. , 1981, Journal of affective disorders.

[16]  R. Hirschfeld,et al.  NIMH clinical research branch collaborative program on the psychobiology of depression. , 1979, Archives of general psychiatry.

[17]  J. Davis,et al.  Overview: maintenance therapy in psychiatry: II. Affective disorders. , 1976, The American journal of psychiatry.

[18]  M. Schou,et al.  Studies on the Course of Recurrent Endogenous Affective Disorders , 1970 .

[19]  Myrna M. Wiessman.  Controlled vs. Naturalistic Experiments: Application of the Life Table Method , 1977 .

[20]  J. Fleiss,et al.  The life table. A method for analyzing longitudinal studies. , 1976, Archives of general psychiatry.

[21]  J. Fleiss,et al.  Lithium Carbonate Prophylaxis Failure , 1976, British Journal of Psychiatry.