Novel role of surfactant protein A in bacterial sinusitis

Chronic rhinosinusitis (CRS) is a common inflammatory disorder of the upper airway characterized by chronic inflammation and significant sinonasal remodeling. CRS is comprised of 2 major subgroups, based on whether polyps are present or absent. In some cases, it is characterized by colonization with opportunistic pathogens such as Pseudomonas aeruginosa (PA), Staphylococcus aureus, and other bacteria. The innate immune system of the sinonasal epithelium is the first line of defense against inhaled pathogens. Surfactant protein A (SP‐A) is a member of the collectin family secreted by the airway epithelia and plays a critical role in airway innate immunity, as it can aggregate bacteria. We hypothesized that SP‐A plays a role in bacterial CRS.

[1]  J. Palmer,et al.  Association between the CDHR3 rs6967330 risk allele and chronic rhinosinusitis. , 2017, The Journal of allergy and clinical immunology.

[2]  R. Rosenfeld.  CLINICAL PRACTICE. Acute Sinusitis in Adults. , 2016, The New England journal of medicine.

[3]  Sarah S. Wilson,et al.  Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions , 2016, Journal of Virology.

[4]  E. Lillehoj,et al.  Pseudomonas aeruginosa stimulates tyrosine phosphorylation of and TLR5 association with the MUC1 cytoplasmic tail through EGFR activation , 2016, Inflammation Research.

[5]  J. Ledford,et al.  Genetic Variation in SP-A2 Leads to Differential Binding to Mycoplasma pneumoniae Membranes and Regulation of Host Responses , 2015, The Journal of Immunology.

[6]  I. Jaspers,et al.  Culturing of human nasal epithelial cells at the air liquid interface. , 2013, Journal of visualized experiments : JoVE.

[7]  Sarah S. Wilson,et al.  Antiviral Mechanisms of Human Defensins , 2013, Journal of Molecular Biology.

[8]  H. Goossens,et al.  EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. , 2012, Rhinology.

[9]  B. Geisbrecht,et al.  Surfactant Protein A (SP-A)-mediated Clearance of Staphylococcus aureus Involves Binding of SP-A to the Staphylococcal Adhesin Eap and the Macrophage Receptors SP-A Receptor 210 and Scavenger Receptor Class A* , 2010, The Journal of Biological Chemistry.

[10]  Robert B Sim,et al.  The human lung surfactant proteins A (SP-A) and D (SP-D) interact with apoptotic target cells by different binding mechanisms. , 2010, Immunobiology.

[11]  D. Hamilos,et al.  Rhinitis and sinusitis. , 2010, The Journal of allergy and clinical immunology.

[12]  E. Ooi,et al.  Innate Immunity in the Paranasal Sinuses: A Review of Nasal Host Defenses , 2008, American journal of rhinology.

[13]  Xiaoxuan Guo,et al.  Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice. , 2007, Toxicology and applied pharmacology.

[14]  Guirong Wang,et al.  Surfactant Protein A2 (SP-A2) Variants Expressed in CHO Cells Stimulate Phagocytosis of Pseudomonas aeruginosa More than Do SP-A1 Variants , 2007, Infection and Immunity.

[15]  E. Ooi,et al.  Surfactant Protein D Expression in Chronic Rhinosinusitis Patients and Immune Responses In Vitro to Aspergillus and Alternaria in a Nasal Explant Model , 2007, The Laryngoscope.

[16]  R. Schlosser,et al.  Immunolocalization of Surfactant Protein A and D in Sinonasal Mucosa , 2006, American journal of rhinology.

[17]  S. Chae,et al.  Upregulation of Surfactant Protein A in Chronic Rhinosinusitis , 2006, The Laryngoscope.

[18]  J. Wright,et al.  Pseudomonas aeruginosa degrades pulmonary surfactant and increases conversion in vitro. , 2005, American journal of respiratory cell and molecular biology.

[19]  J. Hiscott,et al.  The interferon antiviral response: from viral invasion to evasion , 2002, Current opinion in infectious diseases.

[20]  M. Harmsen,et al.  Antiviral activities of lactoferrin. , 2001, Antiviral research.

[21]  D. Phelps.  Surfactant Regulation of Host Defense Function in the Lung: A Question of Balance , 2001, Pediatric pathology & molecular medicine.

[22]  J. Whitsett,et al.  Distinct Effects of Surfactant Protein A or D Deficiency During Bacterial Infection on the Lung1 , 2000, The Journal of Immunology.

[23]  J. Whitsett,et al.  Surfactant protein-A enhances respiratory syncytial virus clearance in vivo. , 1999, The Journal of clinical investigation.

[24]  K. Hartshorn,et al.  Pulmonary surfactant proteins A and D enhance neutrophil uptake of bacteria. , 1998, American journal of physiology. Lung cellular and molecular physiology.

[25]  J. Wright.  Immunoregulatory functions of surfactant proteins , 2005, Nature Reviews Immunology.

[26]  E. Crouch,et al.  Surfactant proteins a and d and pulmonary host defense. , 2001, Annual review of physiology.

[27]  R. Pariente.  The pulmonary surfactant. , 1972, Pathobiology annual.