Spinal cord compression and blood flow

The effect of cerebrospinal fluid pressure (CSFP) on spinal cord blood flow (SCBF), measured by the hydrogen clearance technique, was studied in dogs. CSFP was altered by the infusion of mock CSF into the lumbar subarachnoid space. Occluding snares at T-13 limited the effect of raised pressure on the brain. As the perfusion pressure was reduced when the CSFP was increased, flow remained constant up to a perfusion pressure of approximately 50 mm Hg. Below this value, flow decreased with decreasing perfusion pressure. Normal flow values could be reestablished even at a raised CSFP if the perfusion pressure was increased by raising the arterial blood pressure. Rapid reduction of CSFP was accompanied by reactive hyperemia. The autoregulation of flow down to a perfusion pressure of 50 mm Hg was due to progressive decrease in vascular resistance. Carbon dioxide - responsiveness of the vessels was decreased markedly as the perfusion pressure was reduced.

[1]  Charles Tator,et al.  Review of the measurement of normal spinal cord blood flow , 1976, Brain Research.

[2]  Charles Tator,et al.  Regional spinal cord blood flow in primates. , 1976, Journal of neurosurgery.

[3]  A. Kobrine,et al.  Preserved autoregulation in the rhesus spinal cord after high cervical cord section. , 1976, Journal of neurosurgery.

[4]  J. Rowan,et al.  Spinal cord blood flow measured by a hydrogen clearance technique , 1975, Journal of the Neurological Sciences.

[5]  M. Raichle,et al.  Effects of increased intracranial pressure on cerebral blood volume, blood flow, and oxygen utilization in monkeys. , 1975, Journal of neurosurgery.

[6]  A. Martins,et al.  Spinal cord blood flow in the rhesus monkey by the hydrogen clearance method. , 1974, Surgical neurology.

[7]  J O Rowan,et al.  Raised intracranial pressure and cerebral blood flow , 1974, Journal of neurology, neurosurgery, and psychiatry.

[8]  I. Griffiths.  Spinal cord blood flow in dogs: the effect of blood pressure , 1973, Journal of neurology, neurosurgery, and psychiatry.

[9]  J O Rowan,et al.  Raised intracranial pressure and cerebral blood flow , 1973, Journal of neurology, neurosurgery, and psychiatry.

[10]  R. Johnson,et al.  "Pseudoclaudication" syndrome produced by compression of the cauda equina. , 1968, JAMA.

[11]  K. Shulman,et al.  Cerebral vascular resistance changes in response to cerebrospinal fluid pressure. , 1967, American Journal of Physiology.

[12]  T. Langfitt,et al.  Cerebral blood flow with intracranial hypertension , 1965, Neurology.

[13]  K. Shulman.  SMALL ARTERY AND VEIN PRESSURES IN THE SUBARACHNOID SPACE OF THE DOG. , 1965, The Journal of surgical research.

[14]  F. W. Kerr,et al.  BLOOD PRESSURE RESPONSES IN ACUTE COMPRESSION OF THE SPINAL CORD. , 1964, Journal of neurosurgery.

[15]  R. Terry,et al.  Experiences with metastatic neoplasms involving the spinal cord , 1959, Neurology.

[16]  W. R. Brain,et al.  Discussion on Rupture of the Intervertebral Disc in the Cervical Region , 1948, Proceedings of the Royal Society of Medicine.

[17]  M. Fog.  INFLUENCE OF INTRACRANIAL HYPERTENSION UPON THE CEREBRAL CIRCULATION , 1933 .

[18]  H. Wolff,et al.  THE CEREBRAL CIRCULATION: v. OBSERVATIONS OF THE PIAL CIRCULATION DURING CHANGES IN INTRACRANIAL PRESSURE , 1928 .

[19]  T. Emerson,et al.  Effects of Local Increases of Venous Pressure on Canine Cerebral Hemodynamics , 1975 .

[20]  J. Miller,et al.  Concepts of cerebral perfusion pressure and vascular compression during intracranial hypertension. , 1972, Progress in brain research.

[21]  G. Kindt.  Autoregulation of spinal cord blood flow. , 1971, European neurology.

[22]  0.,et al.  Raised intracranial pressure and cerebral blood flow Venous outflow tract pressures and vascular resistances in experimental intracranial hypertension , 2022 .