Neutralizing inhibitors in the airways of naïve ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses.

[1]  L. Hartley-Tassell,et al.  Ferrets exclusively synthesize Neu5Ac and express naturally humanized influenza A virus receptors , 2014, Nature Communications.

[2]  N. Majó,et al.  Heterogeneous pathological outcomes after experimental pH1N1 influenza infection in ferrets correlate with viral replication and host immune responses in the lung , 2014, Veterinary Research.

[3]  Louise A. Carolan,et al.  TaqMan real time RT-PCR assays for detecting ferret innate and adaptive immune responses , 2014, Journal of Virological Methods.

[4]  S. Maurer-Stroh,et al.  Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection , 2014, Viruses.

[5]  J. Ting,et al.  Type I IFN Triggers RIG-I/TLR3/NLRP3-dependent Inflammasome Activation in Influenza A Virus Infected Cells , 2013, PLoS pathogens.

[6]  A. Mantovani,et al.  Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses , 2013, PloS one.

[7]  Stephen S. H. Huang,et al.  Sequencing, Annotation, and Characterization of the Influenza Ferret Infectome , 2012, Journal of Virology.

[8]  H. Jin,et al.  Surface glycoproteins of influenza A H3N2 virus modulate virus replication in the respiratory tract of ferrets. , 2012, Virology.

[9]  J. Taubenberger,et al.  Human H-Ficolin Inhibits Replication of Seasonal and Pandemic Influenza A Viruses , 2012, The Journal of Immunology.

[10]  Ying Zhu,et al.  L-Ficolin Binds to the Glycoproteins Hemagglutinin and Neuraminidase and Inhibits Influenza A Virus Infection Both in vitro and in vivo , 2012, Journal of Innate Immunity.

[11]  J. Fox,et al.  Decoding the Distribution of Glycan Receptors for Human-Adapted Influenza A Viruses in Ferret Respiratory Tract , 2012, PloS one.

[12]  T. Tumpey,et al.  Local innate immune responses and influenza virus transmission and virulence in ferrets. , 2012, The Journal of infectious diseases.

[13]  G. Kobinger,et al.  Virulence differences of closely related pandemic 2009 H1N1 isolates correlate with increased inflammatory responses in ferrets. , 2012, Virology.

[14]  J. Oxford,et al.  Potential role of human challenge studies for investigation of influenza transmission. , 2011, The Lancet. Infectious diseases.

[15]  Nikolaos M. Nikolaidis,et al.  Mutagenesis of Surfactant Protein D Informed by Evolution and X-ray Crystallography Enhances Defenses against Influenza A Virus in Vivo* , 2011, The Journal of Biological Chemistry.

[16]  T. Kuiken,et al.  Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro , 2011, PloS one.

[17]  Andrew G. Brooks,et al.  Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice , 2011, The Journal of Immunology.

[18]  Jen-Ren Wang,et al.  Galectin-1 Binds to Influenza Virus and Ameliorates Influenza Virus Pathogenesis , 2011, Journal of Virology.

[19]  K. Subbarao,et al.  The contribution of animal models to the understanding of the host range and virulence of influenza A viruses. , 2011, Microbes and infection.

[20]  M. Tate,et al.  Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice. , 2011, Virology.

[21]  M. Tate,et al.  Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice. , 2011, Virology.

[22]  M. Tate,et al.  Inhibition of lectin‐mediated innate host defences in vivo modulates disease severity during influenza virus infection , 2011, Immunology and cell biology.

[23]  Byung-Min Song,et al.  Pandemic H1N1 influenza virus causes a stronger inflammatory response than seasonal H1N1 influenza virus in ferrets , 2011, Archives of Virology.

[24]  S. Thiel,et al.  Lack of the pattern recognition molecule mannose-binding lectin increases susceptibility to influenza A virus infection , 2010, BMC Immunology.

[25]  A. Mantovani,et al.  Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies , 2010, The Journal of Immunology.

[26]  T. Kuiken,et al.  Comparative Pathology of Select Agent Influenza A Virus Infections , 2010, Veterinary pathology.

[27]  H. Jin,et al.  Influenza H1N1 A/Solomon Island/3/06 Virus Receptor Binding Specificity Correlates with Virus Pathogenicity, Antigenicity, and Immunogenicity in Ferrets , 2010, Journal of Virology.

[28]  B. Searle.  Scaffold: A bioinformatic tool for validating MS/MS‐based proteomic studies , 2010, Proteomics.

[29]  M. Tate,et al.  Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice , 2009, Respiratory research.

[30]  R. Webby,et al.  Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D , 2008, Respiratory research.

[31]  M. Tate,et al.  The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice , 2008, Respiratory research.

[32]  Penny A. Rudd,et al.  Severe seasonal influenza in ferrets correlates with reduced interferon and increased IL-6 induction. , 2008, Virology.

[33]  A. Mantovani,et al.  Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses1 , 2008, The Journal of Immunology.

[34]  Kimberly B. Ulett,et al.  N-Linked Glycosylation Attenuates H3N2 Influenza Viruses , 2007, Journal of Virology.

[35]  K. Hartshorn,et al.  Inhibition of hemagglutination activity of influenza A viruses by SP-A1 and SP-A2 variants expressed in CHO cells , 2007, Medical Microbiology and Immunology.

[36]  Chang-Hoon Kim,et al.  Expression and localization of surfactant proteins in human nasal epithelium. , 2007, American journal of physiology. Lung cellular and molecular physiology.

[37]  U. Holmskov,et al.  Salivary agglutinin and lung scavenger receptor cysteine-rich glycoprotein 340 have broad anti-influenza activities and interactions with surfactant protein D that vary according to donor source and sialylation. , 2006, The Biochemical journal.

[38]  David J. Evans,et al.  Surfactant Protein D Is Present in Human Tear Fluid and the Cornea and Inhibits Epithelial Cell Invasion by Pseudomonas aeruginosa , 2005, Infection and Immunity.

[39]  J. Goerke,et al.  Pulmonary Collectins Modulate Strain-Specific Influenza A Virus Infection and Host Responses , 2004, Journal of Virology.

[40]  K. Hartshorn,et al.  Interactions of influenza A virus with sialic acids present on porcine surfactant protein D. , 2004, American journal of respiratory cell and molecular biology.

[41]  K. Hartshorn,et al.  Porcine Pulmonary Collectins Show Distinct Interactions with Influenza A Viruses: Role of the N-Linked Oligosaccharides in the Carbohydrate Recognition Domain1 , 2003, The Journal of Immunology.

[42]  R. Aebersold,et al.  A statistical model for identifying proteins by tandem mass spectrometry. , 2003, Analytical chemistry.

[43]  Alexey I Nesvizhskii,et al.  Empirical statistical model to estimate the accuracy of peptide identifications made by MS/MS and database search. , 2002, Analytical chemistry.

[44]  K. Hartshorn,et al.  Porcine surfactant protein D is N-glycosylated in its carbohydrate recognition domain and is assembled into differently charged oligomers. , 2002, American journal of respiratory cell and molecular biology.

[45]  S. Hawgood,et al.  Surfactant protein-A--deficient mice display an exaggerated early inflammatory response to a beta-resistant strain of influenza A virus. , 2002, American journal of respiratory cell and molecular biology.

[46]  J. Whitsett,et al.  Absence of SP-A modulates innate and adaptive defense responses to pulmonary influenza infection. , 2002, American journal of physiology. Lung cellular and molecular physiology.

[47]  J. Whitsett,et al.  Surfactant Protein D Enhances Clearance of Influenza A Virus from the Lung In Vivo1 , 2001, The Journal of Immunology.

[48]  T. Hartung,et al.  Characteristics of surfactant protein A and D binding to lipoteichoic acid and peptidoglycan, 2 major cell wall components of gram-positive bacteria. , 2001, The Journal of infectious diseases.

[49]  K. Zaner,et al.  Mechanism of binding of surfactant protein D to influenza A viruses: importance of binding to haemagglutinin to antiviral activity. , 2000, The Biochemical journal.

[50]  Y. Kawaoka,et al.  Molecular Mechanisms of Serum Resistance of Human Influenza H3N2 Virus and Their Involvement in Virus Adaptation in a New Host , 1998, Journal of Virology.

[51]  L. Morey,et al.  Collectin-mediated antiviral host defense of the lung: evidence from influenza virus infection of mice , 1997, Journal of virology.

[52]  K. Hartshorn,et al.  Interactions of recombinant human pulmonary surfactant protein D and SP-D multimers with influenza A. , 1996, The American journal of physiology.

[53]  M. Harmsen,et al.  Interactions of surfactant protein A with influenza A viruses: binding and neutralization. , 1995, The Journal of infectious diseases.

[54]  P. Reading,et al.  Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. , 1994, The Journal of general virology.

[55]  Y. Kawaoka,et al.  Alpha 2-macroglobulin is the major neutralizing inhibitor of influenza A virus in pig serum. , 1993, Virology.

[56]  D. Jackson,et al.  Bovine and mouse serum beta inhibitors of influenza A viruses are mannose-binding lectins. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[57]  J. Paulson,et al.  4-O-acetyl-N-acetylneuraminic acid in the N-linked carbohydrate structures of equine and guinea pig alpha 2-macroglobulins, potent inhibitors of influenza virus infection. , 1989, The Journal of biological chemistry.

[58]  J. Paulson,et al.  Basis for the potent inhibition of influenza virus infection by equine and guinea pig alpha 2-macroglobulin. , 1989, The Journal of biological chemistry.

[59]  G. N. Rogers,et al.  Relationship between mitogenic activity of influenza viruses and the receptor-binding specificity of their hemagglutinin molecules , 1986, Journal of virology.

[60]  J. Paulson,et al.  Differential sensitivity of human, avian, and equine influenza A viruses to a glycoprotein inhibitor of infection: selection of receptor specific variants. , 1983, Virology.

[61]  I. Wilson,et al.  Single amino acid substitutions in influenza haemagglutinin change receptor binding specificity , 1983, Nature.

[62]  C. Sweet,et al.  The local origin of the febrile response induced in ferrets during respiratory infection with a virulent influenza virus. , 1979, British journal of experimental pathology.

[63]  Wilson Smith,et al.  A Virus obtained from influenza patients , 1933 .

[64]  T. Tumpey,et al.  Use of animal models to understand the pandemic potential of highly pathogenic avian influenza viruses. , 2009, Advances in virus research.

[65]  S. Lal,et al.  Adaptation of human influenza H3N2 virus in a mouse pneumonitis model: insights into viral virulence, tissue tropism and host pathogenesis. , 2009, Microbes and infection.

[66]  U. Holmskov,et al.  Species differences in the carbohydrate binding preferences of surfactant protein D. , 2006, American journal of respiratory cell and molecular biology.

[67]  L. Brown,et al.  An analysis of the properties of monoclonal antibodies directed to epitopes on influenza virus hemagglutinin , 2005, Archives of Virology.

[68]  K. Hartshorn,et al.  Enhanced anti-influenza activity of a surfactant protein D and serum conglutinin fusion protein. , 2000, American journal of physiology. Lung cellular and molecular physiology.

[69]  P. Reading,et al.  Changes in the hemagglutinin molecule of influenza type A (H3N2) virus associated with increased virulence for mice , 1997, Archives of Virology.

[70]  R. Connor,et al.  Receptor specificity of influenza virus influences severity of illness in ferrets. , 1995, Vaccine.

[71]  C. Sweet,et al.  Lessons for human influenza from pathogenicity studies with ferrets. , 1988, Reviews of infectious diseases.

[72]  I. Cobden,et al.  初期食道静脈りゅう治療におけるテルイプレシン(グリプレシン)とバソプレシンの比較試験 , 1982 .

[73]  A. Gottschalk.  Glycoproteins: Their composition, structure and function , 1972 .

[74]  O. Krizanova,et al.  Serum inhibitors of myxoviruses. , 1969, Current topics in microbiology and immunology.