A Case of Invasive Gastrointestinal Mycotypha Infection in a Patient with Neutropenia

Gastrointestinal mucormycosis is a rare life-threatening infection to which neutropenic patients are especially vulnerable. Mycotypha microspora is a mucormycete that has not been described as a human pathogen. We discuss the successful eradication of gastrointestinal Mycotypha microspora in a neutropenic patient with simultaneous pulmonary Aspergillus fumigatus infection.

[1]  W. Hager,et al.  and s , 2019, Shallow Water Hydraulics.

[2]  D. Kontoyiannis,et al.  Breakthrough Invasive Fungal Infections (bIFI) in Adult Patients with Leukemia Receiving Isavuconazole (ISA) , 2017 .

[3]  A. Ibrahim,et al.  Molecular mechanisms of mucormycosis—The bitter and the sweet , 2017, PLoS pathogens.

[4]  A. Rapose,et al.  Rapidly progressing dual infection with Aspergillus and Rhizopus: when soil inhabitants become deadly invaders , 2016, BMJ Case Reports.

[5]  J. Ito,et al.  Breakthrough Invasive Fungal Infections in Patients with Hematologic Malignancy (HM) and Hematopoietic Cell Transplantation (HCT) Receiving Isavuconazole for Empiric or Directed Antifungal Therapy , 2016 .

[6]  D. Denning,et al.  Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. , 2016, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[7]  C. Fraser,et al.  An integrated genomic and transcriptomic survey of mucormycosis-causing fungi , 2016, Nature Communications.

[8]  E. Swiatlo,et al.  Breaking the Mold , 2016, The Annals of pharmacotherapy.

[9]  J. Baddley,et al.  Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial , 2016, The Lancet.

[10]  J. Wingard,et al.  Combination Antifungal Therapy for Invasive Aspergillosis , 2015, Annals of Internal Medicine.

[11]  L. Mendoza,et al.  Human Fungal Pathogens of Mucorales and Entomophthorales. , 2015, Cold Spring Harbor perspectives in medicine.

[12]  A. Addeo,et al.  The role of surgery in a case of diffuse mucormycosis with haematemesis and gastric necrosis. , 2014, Annals of the Royal College of Surgeons of England.

[13]  L. Pagano,et al.  ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013. , 2014, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.

[14]  J. Montoya,et al.  Utility of DNA sequencing for direct identification of invasive fungi from fresh and formalin-fixed specimens. , 2013, American journal of clinical pathology.

[15]  M. Wrzosek,et al.  DNA barcoding in Mucorales: an inventory of biodiversity , 2013, Persoonia.

[16]  W. Marsden.  I and J , 2012 .

[17]  K. Kleesiek,et al.  Evaluation of Novel Broad-Range Real-Time PCR Assay for Rapid Detection of Human Pathogenic Fungi in Various Clinical Specimens , 2008, Journal of Clinical Microbiology.

[18]  T. Leblanc,et al.  Isolation of Mycotypha microspora from stool samples of a leukemic child , 2007 .

[19]  G. Klintmalm,et al.  Combination of Voriconazole and Caspofungin as Primary Therapy for Invasive Aspergillosis in Solid Organ Transplant Recipients: A Prospective, Multicenter, Observational Study , 2006, Transplantation.

[20]  R. Barbó,et al.  Combination Antifungal Therapy for Invasive Aspergillosis , 2005 .

[21]  T. Patterson,et al.  Efficacy of Caspofungin Alone and in Combination with Voriconazole in a Guinea Pig Model of Invasive Aspergillosis , 2002, Antimicrobial Agents and Chemotherapy.

[22]  J. Ribes,et al.  Zygomycetes in human disease. , 2000, Clinical microbiology reviews.

[23]  E. Fenner.  Mycotypha Microspora, a New Genus of the Mucoraceae , 1932 .