Gut inflammation and adaptive immunity amplify acetaminophen toxicity in bowel and liver

Prevention of liver failure arising from accidental or deliberate paracetamol (acetaminophen [APAP]) overdose remains a vexed health problem despite well‐publicized guidelines for its early detection and treatment. It is recognized that the gut may aggravate liver pathology, via the gut–liver axis. The main aim of this study was to assess the role of the colon in APAP‐induced liver toxicity.

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