Optimization of nucleophilic 18F radiofluorinations using a microfluidic reaction approach

[1]  Mark A. Eddings,et al.  A microreactor with phase-change microvalves for batch chemical synthesis at high temperatures and pressures. , 2014, Lab on a chip.

[2]  I. Greguric,et al.  Ascertaining the suitability of aryl sulfonyl fluorides for [18F]radiochemistry applications: a systematic investigation using microfluidics. , 2013, The Journal of organic chemistry.

[3]  R. Krasikova PET Radiochemistry Automation: State of the Art and Future Trends in 18F-nucleophilic Fluorination , 2013 .

[4]  Steven H. Liang,et al.  Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds. , 2013, Chemical communications.

[5]  Paul Watts,et al.  Microfluidics in radiopharmaceutical chemistry. , 2013, Nuclear medicine and biology.

[6]  V. Samper,et al.  Microfluidics: A Groundbreaking Technology for PET Tracer Production? , 2013, Molecules.

[7]  Paul Watts,et al.  Radiochemistry on chip: towards dose-on-demand synthesis of PET radiopharmaceuticals. , 2013, Lab on a chip.

[8]  M. Buchsbaum,et al.  Batch-reactor microfluidic device: first human use of a microfluidically produced PET radiotracer. , 2013, Lab on a chip.

[9]  C. Halldin,et al.  Radiofluorination and reductive amination using a microfluidic device , 2012 .

[10]  W. Wadsak,et al.  Radiolabeling of [18F]altanserin - a microfluidic approach. , 2012, Nuclear medicine and biology.

[11]  Michael J Welch,et al.  A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35 years of the ISRC? , 2012, Nuclear medicine and biology.

[12]  P. Watts,et al.  Positron Emission Tomography Radiosynthesis in Microreactors , 2012, Journal of Flow Chemistry.

[13]  C. Manera,et al.  Use of non-azeotropically dried complex in microfluidic radiofluorinations , 2012 .

[14]  M. Wuest,et al.  Microfluidic technology: an economical and versatile approach for the synthesis of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET). , 2012, Bioorganic & medicinal chemistry letters.

[15]  Peter J. H. Scott,et al.  Radiochemical Syntheses: Radiopharmaceuticals for Positron Emission Tomography , 2012 .

[16]  H. Wester,et al.  Cryptate mediated nucleophilic 18F-fluorination without azeotropic drying , 2011, Nuklearmedizin.

[17]  Saman Sadeghi,et al.  Micro-chemical synthesis of molecular probes on an electronic microfluidic device , 2011, Proceedings of the National Academy of Sciences.

[18]  O. Neels,et al.  Radiosynthesis of a Novel PET Fluoronicotinamide for Melanoma Tumour PET Imaging; [18F]MEL050 , 2011 .

[19]  G. Pascali,et al.  Dose-on-demand of diverse 18F-fluorocholine derivatives through a two-step microfluidic approach. , 2011, Nuclear medicine and biology.

[20]  Linlin Qin,et al.  Unprecedented directing group ability of cyclophanes in arene fluorinations with diaryliodonium salts. , 2011, Organic letters.

[21]  C. Manera,et al.  Microfluidic approach for fast labeling optimization and dose-on-demand implementation. , 2010, Nuclear medicine and biology.

[22]  A. Luxen,et al.  Fast production of highly concentrated reactive [18F] fluoride for aliphatic and aromatic nucleophilic radiolabelling , 2010 .

[23]  Shuiyu Lu,et al.  Synthesis of [F]fallypride in a micro-reactor: rapid optimization and multiple-production in small doses for micro-PET studies. , 2009, Current radiopharmaceuticals.

[24]  Nicholas J Long,et al.  Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography. , 2008, Angewandte Chemie.

[25]  Lisheng Cai,et al.  Chemistry with [18F]Fluoride Ion , 2008 .

[26]  Antony D. Gee,et al.  Synthesis of 11 C , 18 F , 15 O , and 13 N Radiolabels for Positron Emission Tomography , 2008 .

[27]  D. Lee,et al.  Rapid synthesis of [18F]FDG without an evaporation step using an ionic liquid. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

[28]  D. Kiesewetter,et al.  Use of 1,8‐bis‐(dimethylamino)‐naphthalene/H18F complex as new radiofluorinating agent , 2004 .