4-(3-Fluoro-4-nitrophenyl)morpholin-3-one

In the title compound, C10H9FN2O4, the dihedral angle between the benzene ring and the nitro group plane is 11.29 (3)°. The morpholinone ring adopts a twist-chair conformation. In the crystal, molecules are linked by intermolecular C—H⋯O hydrogen bonds into a chain along the a-axis direction.

[1]  Martin Stahl,et al.  Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit. , 2009, European journal of medicinal chemistry.

[2]  D. Cheney,et al.  Factor Xa inhibitors: next-generation antithrombotic agents. , 2010, Journal of medicinal chemistry.

[3]  W. Ageno,et al.  New direct thrombin inhibitors , 2009, Internal and emergency medicine.

[4]  G. Sheldrick A short history of SHELX. , 2008, Acta crystallographica. Section A, Foundations of crystallography.

[5]  M. Samama,et al.  Newer anticoagulants in 2009 , 2009, Journal of Thrombosis and Thrombolysis.

[6]  S. Haas New oral Xa and IIa inhibitors: updates on clinical trial results , 2008, Journal of Thrombosis and Thrombolysis.

[7]  Kevin J Filipski,et al.  Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. , 2009, Bioorganic & medicinal chemistry.

[8]  G. G. Stokes "J." , 1890, The New Yale Book of Quotations.