Nanoparticles of biodegradable polymers for new-concept chemotherapy

The current regimen of chemotherapy is far from satisfactory – its efficiency is limited and patients suffer from serious side effects. Various drug delivery devices have been under intensive investigation in the past few decades in attempts to develop controlled and targeted methods of chemotherapy administration. This article reviews the latest developments in nanoparticles of biodegradable polymers for chemotherapy of cancer and other diseases such as cardiovascular restenosis. The preliminary results obtained in the author’s laboratory are used to demonstrate the concept. This review is written with the belief that engineering, in particular, chemical engineering principles, can be applied and further developed to solve the problems in the current practice of chemotherapy and promote a new concept of chemotherapy – chemotherapy at home.

[1]  R. Brown,et al.  Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs , 1999, Expert Reviews in Molecular Medicine.

[2]  R. Langer,et al.  Biomaterials in drug delivery and tissue engineering: one laboratory's experience. , 2000, Accounts of chemical research.

[3]  C. Bocca,et al.  Cellular uptake and cytotoxicity of solid lipid nanospheres (SLN) incorporating doxorubicin or paclitaxel. , 2000, International journal of pharmaceutics.

[4]  S. Feng,et al.  A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[5]  P. Cullis,et al.  Drug Delivery Systems: Entering the Mainstream , 2004, Science.

[6]  R. Liggins,et al.  Polyether-polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. , 2002, Advanced drug delivery reviews.

[7]  S. Feng,et al.  Methoxy poly(ethylene glycol)-poly(lactide) (MPEG-PLA) nanoparticles for controlled delivery of anticancer drugs. , 2004, Biomaterials.

[8]  Qiang Zhang,et al.  In vitro and in vivo study of two types of long-circulating solid lipid nanoparticles containing paclitaxel. , 2001, Chemical & pharmaceutical bulletin.

[9]  C Vigneron,et al.  Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[10]  Si-Shen Feng,et al.  Effects of particle size and surface coating on cellular uptake of polymeric nanoparticles for oral delivery of anticancer drugs. , 2005, Biomaterials.

[11]  S. Simões,et al.  Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[12]  Maria José Alonso,et al.  Comparative Uptake Studies of Bioadhesive and Non-Bioadhesive Nanoparticles in Human Intestinal Cell Lines and Rats: The Effect of Mucus on Particle Adsorption and Transport , 2002, Pharmaceutical Research.

[13]  J. Schellens,et al.  Phase I and pharmacokinetic study of oral paclitaxel. , 2000, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[14]  S. Feng,et al.  Preparation and characterization of poly(lactic acid)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PLA) microspheres for controlled release of paclitaxel. , 2003, Biomaterials.

[15]  Min Huang,et al.  Uptake and Cytotoxicity of Chitosan Molecules and Nanoparticles: Effects of Molecular Weight and Degree of Deacetylation , 2004, Pharmaceutical Research.

[16]  S. Feng,et al.  Vitamin E TPGS used as emulsifier in the solvent evaporation/extraction technique for fabrication of polymeric nanospheres for controlled release of paclitaxel (Taxol). , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[17]  N. Behan,et al.  Poly n-butyl cyanoacrylate nanoparticles: a mechanistic study of polymerisation and particle formation. , 2001, Biomaterials.

[18]  Si-Shen Feng,et al.  Nanoparticles of biodegradable polymers for clinical administration of paclitaxel. , 2004, Current medicinal chemistry.

[19]  P. Couvreur,et al.  Nanoparticles in cancer therapy and diagnosis. , 2002, Advanced drug delivery reviews.

[20]  David J Brayden,et al.  Binding and uptake of biodegradable poly-DL-lactide micro- and nanoparticles in intestinal epithelia. , 1998, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[21]  R K Jain,et al.  Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. , 1995, Cancer research.

[22]  A. Maitra,et al.  Tumour targeted delivery of encapsulated dextran-doxorubicin conjugate using chitosan nanoparticles as carrier. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[23]  K. Sakurai,et al.  PREPARATION AND CHARACTERIZATION OF POLYLACTIDE-POLY(ETHYLENE GLYCOL)-POLYLACTIDE TRIBLOCK POLYMERS AND A PRELIMINARY IN VIVO EXAMINATION OF THE BLOOD CIRCULATION TIME FOR THE NANOPARTICLES MADE THEREFROM , 1999 .

[24]  J. Schellens,et al.  Metabolism and excretion of paclitaxel after oral administration in combination with cyclosporin A and after i.v. administration , 2000, Anti-cancer drugs.

[25]  T. Kissel,et al.  Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[26]  Antonio J. Grillo-López,et al.  Cancer therapies crisis in the USA , 2003, Expert review of anticancer therapy.

[27]  D. Aggarwal,et al.  Paclitaxel and its formulations. , 2002, International journal of pharmaceutics.

[28]  S. Davis,et al.  Drug delivery in poly(lactide-co-glycolide) nanoparticles surface modified with poloxamer 407 and poloxamine 908: in vitro characterisation and in vivo evaluation. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[29]  A. R. Kulkarni,et al.  Biodegradable polymeric nanoparticles as drug delivery devices. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[30]  L. Lim,et al.  Mechanistic study of the uptake of wheat germ agglutinin-conjugated PLGA nanoparticles by A549 cells. , 2004, Journal of pharmaceutical sciences.

[31]  H. Merkle,et al.  Transfer of Lipophilic Markers from PLGA and Polystyrene Nanoparticles to Caco-2 Monolayers Mimics Particle Uptake , 2002, Pharmaceutical Research.

[32]  R. Langer,et al.  Relating the phagocytosis of microparticles by alveolar macrophages to surface chemistry: the effect of 1,2-dipalmitoylphosphatidylcholine. , 1998, Journal of controlled release : official journal of the Controlled Release Society.

[33]  Si-Shen Feng,et al.  Fabrication and characterizations of a novel drug delivery device liposomes-in-microsphere (LIM). , 2004, Biomaterials.

[34]  Gordon L. Amidon,et al.  The Mechanism of Uptake of Biodegradable Microparticles in Caco-2 Cells Is Size Dependent , 1997, Pharmaceutical Research.

[35]  Abraham J. Domb,et al.  Pharmaceutical Polymeric Controlled Drug Delivery Systems , 2002 .

[36]  Tang Yang,et al.  Preparation and distribution of 5-fluorouracil (125)I sodium alginate-bovine serum albumin nanoparticles. , 1999, World journal of gastroenterology.

[37]  S. Feng,et al.  Fabrication, characterization and in vitro release of paclitaxel (Taxol) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[38]  H. von Briesen,et al.  Preparation of avidin-labelled gelatin nanoparticles as carriers for biotinylated peptide nucleic acid (PNA). , 2000, International journal of pharmaceutics.

[39]  P. Couvreur,et al.  Nanoparticulate systems for the delivery of antisense oligonucleotides. , 2001, Advanced drug delivery reviews.

[40]  R. Jain,et al.  Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[41]  A. Hoffman,et al.  A REVERSE MICROEMULSION POLYMERIZATION METHOD FOR PREPARATION OF BIOADHESIVE POLYACRYLIC ACID NANOPARTICLES FOR MUCOSAL DRUG DELIVERY: LOADING AND RELEASE OF TIMOLOL MALEATE , 2001, Artificial cells, blood substitutes, and immobilization biotechnology.

[42]  J. Verweij,et al.  Preclinical evaluation of alternative pharmaceutical delivery vehicles for paclitaxel , 2002, Anti-cancer drugs.

[43]  M. Wientjes,et al.  Determinants of drug delivery and transport to solid tumors. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[44]  J. A. Shabbits,et al.  Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[45]  I. Fishbein,et al.  Nanoparticulate delivery system of a tyrphostin for the treatment of restenosis. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[46]  S. Feng,et al.  Effects of emulsifiers on the controlled release of paclitaxel (Taxol) from nanospheres of biodegradable polymers. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[47]  T. Park,et al.  In vitro and in vivo anti-tumor activities of nanoparticles based on doxorubicin-PLGA conjugates. , 2000, Journal of controlled release : official journal of the Controlled Release Society.

[48]  Robert Langer,et al.  Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive biodegradable system for paclitaxel delivery. , 2003, Journal of controlled release : official journal of the Controlled Release Society.

[49]  Delie,et al.  Evaluation of nano- and microparticle uptake by the gastrointestinal tract. , 1998, Advanced drug delivery reviews.

[50]  Soriano,et al.  The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. , 2000, Colloids and surfaces. B, Biointerfaces.

[51]  J Verweij,et al.  Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. , 2001, European journal of cancer.

[52]  R K Jain,et al.  Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[53]  A. Maitra,et al.  Biodistribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system. , 2000, International journal of pharmaceutics.

[54]  J. Feijen,et al.  Formulation and Lyoprotection of Poly(Lactic Acid-Co-Ethylene Oxide) Nanoparticles: Influence on Physical Stability and In Vitro Cell Uptake , 1999, Pharmaceutical Research.

[55]  T. Park,et al.  Biodegradable Nanoparticles Containing Doxorubicin-PLGA Conjugate for Sustained Release , 1999, Pharmaceutical Research.

[56]  Y. Koyanagi,et al.  Direct measurement of the extravasation of polyethyleneglycol-coated liposomes into solid tumor tissue by in vivo fluorescence microscopy , 1996 .

[57]  K. Janes,et al.  Chitosan nanoparticles as delivery systems for doxorubicin. , 2001, Journal of controlled release : official journal of the Controlled Release Society.

[58]  Shu Chien,et al.  Chemotherapeutic engineering: Application and further development of chemical engineering principles for chemotherapy of cancer and other diseases , 2003 .

[59]  P. Couvreur,et al.  Polycyanoacrylate nanocapsules as potential lysosomotropic carriers: preparation, morphological and sorptive properties , 1979, The Journal of pharmacy and pharmacology.

[60]  M. Lawrence,et al.  Microemulsion-based media as novel drug delivery systems , 2000 .

[61]  T. Lecompte,et al.  In Vitro and In Vivo Evaluation of Oral Heparin–Loaded Polymeric Nanoparticles in Rabbits , 2002, Circulation.

[62]  P. McCarron,et al.  Sustained Release of 5‐Fluorouracil from Polymeric Nanoparticles , 2000, The Journal of pharmacy and pharmacology.

[63]  J. Bacri,et al.  Intracellular uptake of anionic superparamagnetic nanoparticles as a function of their surface coating. , 2003, Biomaterials.

[64]  M. Wientjes,et al.  Clinical aspects of drug delivery to tumors. , 2002, Journal of controlled release : official journal of the Controlled Release Society.

[65]  R. Müller,et al.  Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art. , 2000, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[66]  I. Fishbein,et al.  Formulation and Delivery Mode Affect Disposition and Activity of Tyrphostin-Loaded Nanoparticles in the Rat Carotid Model , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[67]  R. Virmani,et al.  Sustained Reduction of In-Stent Neointimal Growth With the Use of a Novel Systemic Nanoparticle Paclitaxel , 2002, Circulation.

[68]  F. Zanella,et al.  Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma. , 2002, Toxicology letters.

[69]  Haixiong Ge,et al.  DOXORUBICIN-LOADED POLY(BUTYLCYANOACRYLATE) NANOPARTICLES PRODUCED BY EMULSIFIER-FREE EMULSION POLYMERIZATION , 2000 .

[70]  J. Schellens,et al.  Oral Delivery of Taxanes , 2001, Investigational New Drugs.

[71]  Y. Lee,et al.  Toxic characteristics of methoxy poly(ethylene glycol)/poly(epsilon-caprolactone) nanospheres; in vitro and in vivo studies in the normal mice. , 2003, Biomaterials.

[72]  Ravi Kumar M.N.V..  Nano and microparticles as controlled drug delivery devices. , 2000 .

[73]  Si-Shen Feng,et al.  PLGA/TPGS Nanoparticles for Controlled Release of Paclitaxel: Effects of the Emulsifier and Drug Loading Ratio , 2003, Pharmaceutical Research.

[74]  T. Chandy,et al.  Controlled delivery of taxol from poly(ethylene glycol)-coated poly(lactic acid) microspheres. , 2001, Journal of biomedical materials research.

[75]  I. Fishbein,et al.  Drug delivery systems for the treatment of restenosis. , 2000, Critical reviews in therapeutic drug carrier systems.