Nanomedicine for safe healing of bone trauma: Opportunities and challenges.

[1]  K. Landfester,et al.  Suppressing non-controlled leakage of hydrophilic payloads from redox-responsive nanocapsules , 2017 .

[2]  A. A. Zadpoor,et al.  Effects of bone substitute architecture and surface properties on cell response, angiogenesis, and structure of new bone. , 2017, Journal of materials chemistry. B.

[3]  V. Rotello,et al.  Synergistic antimicrobial therapy using nanoparticles and antibiotics for the treatment of multidrug-resistant bacterial infection , 2017 .

[4]  S. Nazhat,et al.  Accelerated craniofacial bone regeneration through dense collagen gel scaffolds seeded with dental pulp stem cells , 2016, Scientific Reports.

[5]  K. Landfester,et al.  The pro-active payload strategy significantly increases selective release from mesoporous nanocapsules. , 2016, Journal of controlled release : official journal of the Controlled Release Society.

[6]  Y. Lei,et al.  Fabrication of silver nanoparticle-doped hydroxyapatite coatings with oriented block arrays for enhancing bactericidal effect and osteoinductivity. , 2016, Journal of the mechanical behavior of biomedical materials.

[7]  D. Bernstein,et al.  Infection-resistant MRI-visible scaffolds for tissue engineering applications , 2016, BioImpacts : BI.

[8]  K. Landfester,et al.  Osmotic pressure-dependent release profiles of payloads from nanocontainers by co-encapsulation of simple salts. , 2016, Nanoscale.

[9]  M. Rohde,et al.  Susceptibility of metallic magnesium implants to bacterial biofilm infections. , 2016, Journal of biomedical materials research. Part A.

[10]  K. Landfester,et al.  A triblock terpolymer vs. blends of diblock copolymers for nanocapsules addressed by three independent stimuli , 2016 .

[11]  R. Farid,et al.  Osteogenic effect of locally applied Pentoxyfilline gel: in vitro and in vivo evaluations , 2015, Drug delivery.

[12]  Bin Zhou,et al.  Epicardial FSTL1 reconstitution regenerates the adult mammalian heart , 2015, Nature.

[13]  A. Boccaccini,et al.  45S5Bioglass®-based scaffolds coated with selenium nanoparticles or with poly(lactide-co-glycolide)/selenium particles: Processing, evaluation and antibacterial activity. , 2015, Colloids and surfaces. B, Biointerfaces.

[14]  Wei Nie,et al.  BMP-2 Derived Peptide and Dexamethasone Incorporated Mesoporous Silica Nanoparticles for Enhanced Osteogenic Differentiation of Bone Mesenchymal Stem Cells. , 2015, ACS applied materials & interfaces.

[15]  P. Cerri,et al.  Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells , 2015, BioMed research international.

[16]  Arash Momeni,et al.  Nanotechnology in bone tissue engineering. , 2015, Nanomedicine : nanotechnology, biology, and medicine.

[17]  Jie Wei,et al.  Peptide-laden mesoporous silica nanoparticles with promoted bioactivity and osteo-differentiation ability for bone tissue engineering. , 2015, Colloids and surfaces. B, Biointerfaces.

[18]  A. Oryan,et al.  Basic concepts regarding fracture healing and the current options and future directions in managing bone fractures , 2015, International wound journal.

[19]  S. Perni,et al.  Silver nanoparticle based antibacterial methacrylate hydrogels potential for bone graft applications , 2015, Materials science & engineering. C, Materials for biological applications.

[20]  M. Capulli,et al.  Osteoblast and osteocyte: games without frontiers. , 2014, Archives of biochemistry and biophysics.

[21]  K. Shakesheff,et al.  Remotely Activated Mechanotransduction via Magnetic Nanoparticles Promotes Mineralization Synergistically With Bone Morphogenetic Protein 2: Applications for Injectable Cell Therapy , 2014, Stem cells translational medicine.

[22]  A. Ivković,et al.  Nanobiotechnology and bone regeneration: a mini-review , 2014, International Orthopaedics.

[23]  Tejal A Desai,et al.  In vitro analysis of nanoparticulate hydroxyapatite/chitosan composites as potential drug delivery platforms for the sustained release of antibiotics in the treatment of osteomyelitis. , 2014, Journal of pharmaceutical sciences.

[24]  Y. Mély,et al.  Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors. , 2014, Macromolecular bioscience.

[25]  Say Chye Joachim Loo,et al.  A controlled release of antibiotics from calcium phosphate-coated poly(lactic-co-glycolic acid) particles and their in vitro efficacy against Staphylococcus aureus biofilm , 2014, Journal of Materials Science: Materials in Medicine.

[26]  Yi Deng,et al.  Peptide decorated nano-hydroxyapatite with enhanced bioactivity and osteogenic differentiation via polydopamine coating. , 2013, Colloids and surfaces. B, Biointerfaces.

[27]  Mitchell B. Schaffler,et al.  Osteocytes: Master Orchestrators of Bone , 2013, Calcified Tissue International.

[28]  J. San Román,et al.  Osteogenic effect of local, long versus short term BMP-2 delivery from a novel SPU-PLGA-βTCP concentric system in a critical size defect in rats. , 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[29]  T. Desai,et al.  Osteogenic and antimicrobial nanoparticulate calcium phosphate and poly-(D,L-lactide-co-glycolide) powders for the treatment of osteomyelitis. , 2013, Materials science & engineering. C, Materials for biological applications.

[30]  Meifang Zhu,et al.  Characterization and antibacterial activity of amoxicillin-loaded electrospun nano-hydroxyapatite/poly(lactic-co-glycolic acid) composite nanofibers. , 2013, Biomaterials.

[31]  J. Jansen,et al.  Comparison of micro- vs. nanostructured colloidal gelatin gels for sustained delivery of osteogenic proteins: Bone morphogenetic protein-2 and alkaline phosphatase. , 2012, Biomaterials.

[32]  M. Jeong,et al.  Osteogenesis induced by a bone forming peptide from the prodomain region of BMP-7. , 2012, Biomaterials.

[33]  Morteza Mahmoudi,et al.  Antibacterial properties of nanoparticles. , 2012, Trends in biotechnology.

[34]  N. Bock,et al.  Innovative magnetic scaffolds for orthopedic tissue engineering. , 2012, Journal of biomedical materials research. Part A.

[35]  G. Duda,et al.  BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway , 2012, BMC Biology.

[36]  M. Fraunholz,et al.  Intracellular staphylococcus aureus: Live-in and let die , 2012, Front. Cell. Inf. Microbio..

[37]  Rassoul Dinarvand,et al.  Chitosan–Pluronic nanoparticles as oral delivery of anticancer gemcitabine: preparation and in vitro study , 2012, International journal of nanomedicine.

[38]  T. Lu,et al.  Surface charge-switching polymeric nanoparticles for bacterial cell wall-targeted delivery of antibiotics. , 2012, ACS nano.

[39]  R. Ritchie,et al.  The Multiscale Origins of Fracture Resistance in Human Bone and Its Biological Degradation , 2012 .

[40]  Omid C Farokhzad,et al.  Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. , 2012, Chemical Society reviews.

[41]  M. Mahmoudi,et al.  Silver-coated engineered magnetic nanoparticles are promising for the success in the fight against antibacterial resistance threat. , 2012, ACS nano.

[42]  P. Stroeve,et al.  Toxicity of nanomaterials. , 2012, Chemical Society reviews.

[43]  C. Mendoza-Palomares,et al.  Smart hybrid materials equipped by nanoreservoirs of therapeutics. , 2012, ACS nano.

[44]  Tarun Garg,et al.  Scaffold: a novel carrier for cell and drug delivery. , 2012, Critical reviews in therapeutic drug carrier systems.

[45]  Young Jik Kwon,et al.  "Nanoantibiotics": a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. , 2011, Journal of controlled release : official journal of the Controlled Release Society.

[46]  María Vallet-Regí,et al.  Bioceramics: From Bone Regeneration to Cancer Nanomedicine , 2011, Advanced materials.

[47]  Wolfgang J. Parak,et al.  Cellular toxicity of inorganic nanoparticles: Common aspects and guidelines for improved nanotoxicity evaluation , 2011 .

[48]  Amitava Mukherjee,et al.  Studies on interaction of colloidal silver nanoparticles (SNPs) with five different bacterial species. , 2011, Colloids and surfaces. B, Biointerfaces.

[49]  N. Selvamurugan,et al.  Preparation, characterization and antimicrobial activity of a bio-composite scaffold containing chitosan/nano-hydroxyapatite/nano-silver for bone tissue engineering. , 2011, International journal of biological macromolecules.

[50]  P. Tran,et al.  Selenium nanoparticles inhibit Staphylococcus aureus growth , 2011, International journal of nanomedicine.

[51]  Omid C Farokhzad,et al.  Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. , 2011, Accounts of chemical research.

[52]  Thomas A Einhorn,et al.  The biology of fracture healing. , 2011, Injury.

[53]  J. Meng,et al.  Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells. , 2010, Nanoscale.

[54]  S. Nazhat,et al.  Reduced hydraulic permeability of three-dimensional collagen scaffolds attenuates gel contraction and promotes the growth and differentiation of mesenchymal stem cells. , 2010, Acta biomaterialia.

[55]  P. Ma,et al.  Novel antibacterial nanofibrous PLLA scaffolds. , 2010, Journal of controlled release : official journal of the Controlled Release Society.

[56]  R. Hsu,et al.  Treatment of osteomyelitis with teicoplanin-encapsulated biodegradable thermosensitive hydrogel nanoparticles. , 2010, Biomaterials.

[57]  Yong-Qing Xu,et al.  Liposome combined porous β-TCP scaffold: Preparation, characterization, and anti-biofilm activity , 2010, Drug delivery.

[58]  A Tampieri,et al.  A novel route in bone tissue engineering: magnetic biomimetic scaffolds. , 2010, Acta biomaterialia.

[59]  A. Dierich,et al.  Active multilayered capsules for in vivo bone formation , 2010, Proceedings of the National Academy of Sciences.

[60]  Ke Karlovu,et al.  The bactericidal effect of silver nanoparticles , 2010 .

[61]  D. Uskoković,et al.  A novel nano drug delivery system based on tigecycline-loaded calciumphosphate coated with poly-dl-lactide-co-glycolide , 2010, Journal of materials science. Materials in medicine.

[62]  P. Prema,et al.  Fabrication and characterization of silver nanoparticle and its potential antibacterial activity , 2009 .

[63]  K. Na,et al.  Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering. , 2009, Journal of bioscience and bioengineering.

[64]  A. Vaccaro,et al.  Spinal reconstruction and bone morphogenetic proteins: open questions. , 2009, Injury.

[65]  Anna Spagnoli,et al.  Regenerative Effects of Transplanted Mesenchymal Stem Cells in Fracture Healing , 2009, Stem cells.

[66]  J. Skepper,et al.  Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability. , 2009, Biomaterials.

[67]  L. David,et al.  Emerging role of bone morphogenetic proteins in angiogenesis. , 2009, Cytokine & growth factor reviews.

[68]  R. Reis,et al.  The osteogenic differentiation of rat bone marrow stromal cells cultured with dexamethasone-loaded carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles. , 2009, Biomaterials.

[69]  W. Garner Pulsed Magnetic Fields Accelerate Cutaneous Wound Healing in Rats , 2009 .

[70]  Ning Gu,et al.  Computational investigation of interaction between nanoparticles and membranes: hydrophobic/hydrophilic effect. , 2008, The journal of physical chemistry. B.

[71]  E H Schemitsch,et al.  Fracture vascularity and bone healing: a systematic review of the role of VEGF. , 2008, Injury.

[72]  W. Landis,et al.  Mineral Deposition in the Extracellular Matrices of Vertebrate Tissues: Identification of Possible Apatite Nucleation Sites on Type I Collagen , 2008, Cells Tissues Organs.

[73]  M. Yavropoulou,et al.  Osteoclastogenesis--current knowledge and future perspectives. , 2008, Journal of musculoskeletal & neuronal interactions.

[74]  A. Mikos,et al.  Modulation of the inflammatory response for enhanced bone tissue regeneration. , 2008, Tissue engineering. Part B, Reviews.

[75]  Siddhartha P Duttagupta,et al.  Strain specificity in antimicrobial activity of silver and copper nanoparticles. , 2008, Acta biomaterialia.

[76]  J. Czernuszka,et al.  Controlled release of amoxicillin from hydroxyapatite-coated poly(lactic-co-glycolic acid) microspheres. , 2008, Journal of controlled release : official journal of the Controlled Release Society.

[77]  T. Plesner,et al.  A physical mechanism for coupling bone resorption and formation in adult human bone , 2008 .

[78]  D. Graves,et al.  Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis , 2008, Journal of dental research.

[79]  N. Pleshko Camacho,et al.  Callus mineralization and maturation are delayed during fracture healing in interleukin-6 knockout mice. , 2007, Bone.

[80]  Meital Zilberman,et al.  Gentamicin-loaded bioresorbable films for prevention of bacterial infections associated with orthopedic implants. , 2007, Journal of biomedical materials research. Part A.

[81]  Rubén D Sinisterra,et al.  Polymer: bioceramic composites optimization by tetracycline addition. , 2007, International journal of pharmaceutics.

[82]  P. Giannoudis,et al.  The health economics of the treatment of long-bone non-unions. , 2007, Injury.

[83]  William V Giannobile,et al.  The enhancement of osteogenesis by nano-fibrous scaffolds incorporating rhBMP-7 nanospheres. , 2007, Biomaterials.

[84]  S. Fuchs,et al.  Anaerobic Gene Expression in Staphylococcus aureus , 2007, Journal of bacteriology.

[85]  T. SAMPATH KUMAR,et al.  Antibacterial nanosized silver substituted hydroxyapatite: synthesis and characterization. , 2007, Journal of biomedical materials research. Part A.

[86]  H. Uludaǧ,et al.  'Magic bullets' for bone diseases: progress in rational design of bone-seeking medicinal agents. , 2007, Chemical Society reviews.

[87]  D. Uskoković,et al.  Biphasic calcium phosphate coated with poly-d,l-lactide-co-glycolide biomaterial as a bone substitute , 2007 .

[88]  S. Wise Nanocarriers as an emerging platform for cancer therapy , 2007 .

[89]  R. Langer,et al.  Nanomedicine: developing smarter therapeutic and diagnostic modalities. , 2006, Advanced drug delivery reviews.

[90]  D. Uskoković,et al.  Cytotoxicity and fibroblast properties during in vitro test of biphasic calcium phosphate/poly‐dl‐lactide‐co‐glycolide biocomposites and different phosphate materials , 2006, Microscopy research and technique.

[91]  Kim, Mi Kyoung,et al.  Overexpression of CXCR4 increases migration and proliferation of human adipose tissue stromal cells. , 2006, Stem cells and development.

[92]  C. Tabin,et al.  BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing , 2006, Nature Genetics.

[93]  Thomas A. Einhorn,et al.  Fracture healing in the elderly patient , 2006, Experimental Gerontology.

[94]  Franck Chauvat,et al.  Cytotoxicity of CeO2 nanoparticles for Escherichia coli. Physico-chemical insight of the cytotoxicity mechanism. , 2006, Environmental science & technology.

[95]  Yoshihisa Suzuki,et al.  Repair of 20-mm long rabbit radial bone defects using BMP-derived peptide combined with an alpha-tricalcium phosphate scaffold. , 2006, Journal of biomedical materials research. Part A.

[96]  K. Neoh,et al.  Antibacterial and mechanical properties of bone cement impregnated with chitosan nanoparticles. , 2006, Biomaterials.

[97]  M. Eijken,et al.  The essential role of glucocorticoids for proper human osteoblast differentiation and matrix mineralization , 2006, Molecular and Cellular Endocrinology.

[98]  Robert A. Brown,et al.  Ultrarapid Engineering of Biomimetic Materials and Tissues: Fabrication of Nano‐ and Microstructures by Plastic Compression , 2005 .

[99]  S. Buchman,et al.  Colocalization of c-Src (pp60src) and Bone Morphogenetic Protein 2/4 Expression During Mandibular Distraction Osteogenesis: In Vivo Evidence of Their Role Within an Integrin-Mediated Mechanotransduction Pathway , 2005, Annals of plastic surgery.

[100]  Jacqueline A. Cutroni,et al.  Sacrificial bonds and hidden length dissipate energy as mineralized fibrils separate during bone fracture , 2005, Nature materials.

[101]  J. Aizenberg,et al.  Skeleton of Euplectella sp.: Structural Hierarchy from the Nanoscale to the Macroscale , 2005, Science.

[102]  A. Simpson,et al.  The management of fractures with bone loss. , 2005, The Journal of bone and joint surgery. British volume.

[103]  H. Frost Tetracycline-based histological analysis of bone remodeling , 2005, Calcified Tissue Research.

[104]  Mark Voorneveld,et al.  Preparation , 2018, Games Econ. Behav..

[105]  A. Domb,et al.  Chitosan chemistry and pharmaceutical perspectives. , 2004, Chemical reviews.

[106]  R. Page,et al.  Severely impacted valgus proximal humeral fractures. , 2004, The Journal of bone and joint surgery. American volume.

[107]  J. M. Garcı́a,et al.  Modelling bone tissue fracture and healing: a review ☆ , 2004 .

[108]  Michael Wagener,et al.  An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. , 2004, Biomaterials.

[109]  Yoshihisa Suzuki,et al.  Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. , 2003, Biochimica et biophysica acta.

[110]  R. Page,et al.  Severely impacted valgus proximal humeral fractures. Results of operative treatment. , 2003, The Journal of bone and joint surgery. American volume.

[111]  Thomas L. Smith,et al.  Intracellular Staphylococcus aureus. A mechanism for the indolence of osteomyelitis. , 2003, The Journal of bone and joint surgery. British volume.

[112]  H. Anderson Matrix vesicles and calcification , 2003, Current rheumatology reports.

[113]  C. Zalavras,et al.  Open Fractures: Evaluation and Management , 2003, The Journal of the American Academy of Orthopaedic Surgeons.

[114]  Thomas A Einhorn,et al.  Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation , 2003, Journal of cellular biochemistry.

[115]  M. Young Bone matrix proteins: their function, regulation, and relationship to osteoporosis , 2003, Osteoporosis International.

[116]  H. Bilgili,et al.  In vitro/in vivo evaluation of the efficiency of teicoplanin-loaded biodegradable microparticles formulated for implantation to infected bone defects. , 2003, Journal of microencapsulation.

[117]  M Umezu,et al.  Investigation on the mechanical properties of contracted collagen gels as a scaffold for tissue engineering. , 2003, Artificial organs.

[118]  J. Keating,et al.  Minimal internal fixation and calcium-phosphate cement in the treatment of fractures of the tibial plateau. A pilot study. , 2003, The Journal of bone and joint surgery. British volume.

[119]  S M Perren,et al.  EVOLUTION OF THE INTERNAL FIXATION OF LONG BONE FRACTURES , 2002 .

[120]  M. Bosse,et al.  Timing of closure of open fractures. , 2002, The Journal of the American Academy of Orthopaedic Surgeons.

[121]  Stephan M Perren,et al.  Evolution of the internal fixation of long bone fractures. The scientific basis of biological internal fixation: choosing a new balance between stability and biology. , 2002, The Journal of bone and joint surgery. British volume.

[122]  Matthias Epple,et al.  Biological and medical significance of calcium phosphates. , 2002, Angewandte Chemie.

[123]  Thomas A Einhorn,et al.  Differential Temporal Expression of Members of the Transforming Growth Factor β Superfamily During Murine Fracture Healing , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[124]  P. Saftig,et al.  The Bone Lining Cell: Its Role in Cleaning Howship's Lacunae and Initiating Bone Formation , 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[125]  F. Garcia-alvarez,et al.  Evaluation of four experimental osteomyelitis infection models by using precolonized implants and bacterial suspensions , 2002, Acta orthopaedica Scandinavica.

[126]  S. Stupp,et al.  Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers , 2001, Science.

[127]  Flemming Melsen,et al.  Cancellous Bone Remodeling Occurs in Specialized Compartments Lined by Cells Expressing Osteoblastic Markers , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[128]  A. Simpson,et al.  Skin closure after acute shortening. , 2001, The Journal of bone and joint surgery. British volume.

[129]  L. Munuera,et al.  Treatment of fractures of the distal radius with a remodellable bone cement , 2000 .

[130]  L. Munuera,et al.  Treatment of fractures of the distal radius with a remodellable bone cement: a prospective, randomised study using Norian SRS. , 2000, The Journal of bone and joint surgery. British volume.

[131]  C. Niyibizi,et al.  Novel approaches to fracture healing , 2000, Expert opinion on investigational drugs.

[132]  T. Bauer,et al.  Open reduction and augmentation of internal fixation with an injectable skeletal cement for the treatment of complex calcaneal fractures. , 2000, Journal of orthopaedic trauma.

[133]  S. Manolagas,et al.  Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. , 2000, Endocrine reviews.

[134]  M. Chapman,et al.  Comparison of Antibiotic Beads and Intravenous Antibiotics in Open Fractures , 2000, Clinical orthopaedics and related research.

[135]  J R Mosley,et al.  Osteoporosis and bone functional adaptation: mechanobiological regulation of bone architecture in growing and adult bone, a review. , 2000, Journal of rehabilitation research and development.

[136]  Q. Yang,et al.  Comparison of in vitro and in vivo release characteristics of sustained release ofloxacin microspheres. , 2000, Drug delivery.

[137]  M Raspanti,et al.  Different patterns of collagen-proteoglycan interaction: a scanning electron microscopy and atomic force microscopy study. , 2000, European journal of histochemistry : EJH.

[138]  T A Einhorn,et al.  Growth Factor Regulation of Fracture Repair , 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[139]  S. Wei,et al.  Aggressive treatment of 119 open fracture wounds. , 1999, The Journal of trauma.

[140]  P. Brown,et al.  An Analysis of Hydroxyapatite Surface Layer Formation , 1999 .

[141]  T A Einhorn,et al.  The cell and molecular biology of fracture healing. , 1998, Clinical orthopaedics and related research.

[142]  Steve Weiner,et al.  THE MATERIAL BONE: Structure-Mechanical Function Relations , 1998 .

[143]  A. Parfitt,et al.  Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. , 1998, The Journal of clinical investigation.

[144]  R. Gustilo,et al.  Update on the management of open fractures of the tibial shaft. , 1998, Clinical orthopaedics and related research.

[145]  A. Boskey Biomineralization: Conflicts, challenges, and opportunities , 1998, Journal of cellular biochemistry.

[146]  Makoto Sato,et al.  Targeted Disruption of Cbfa1 Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts , 1997, Cell.

[147]  G. Karsenty,et al.  Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation , 1997, Cell.

[148]  P. Lehenkari,et al.  Removal of osteoclast bone resorption products by transcytosis. , 1997, Science.

[149]  M. Horton,et al.  Trafficking of matrix collagens through bone-resorbing osteoclasts. , 1997, Science.

[150]  Heung Jae Chun,et al.  Synthesis of chitosan derivatives with quaternary ammonium salt and their antibacterial activity , 1997 .

[151]  M. Alonso,et al.  Novel hydrophilic chitosan‐polyethylene oxide nanoparticles as protein carriers , 1997 .

[152]  P. Aspenberg,et al.  Injectable Calcium Phosphate in the Treatment of Distal Radial Fractures , 1996, Journal of hand surgery.

[153]  M. McKee,et al.  Osteopontin at mineralized tissue interfaces in bone, teeth, and osseointegrated implants: Ultrastructural distribution and implications for mineralized tissue formation, turnover, and repair , 1996, Microscopy research and technique.

[154]  Antonios G. Mikos,et al.  Bone tissue engineering , 1995, Nature Medicine.

[155]  R. Gustilo Interobserver agreement in the classification of open fractures of the tibia. The results of a survey of two hundred and forty-five orthopaedic surgeons. , 1995, The Journal of bone and joint surgery. American volume.

[156]  D. Seligson,et al.  Local antibiotic therapy for severe open fractures. A review of 1085 consecutive cases. , 1995, The Journal of bone and joint surgery. British volume.

[157]  R. Brumback,et al.  Interobserver agreement in the classification of open fractures of the tibia. The results of a survey of two hundred and forty-five orthopaedic surgeons. , 1994, The Journal of bone and joint surgery. American volume.

[158]  P. Nijweide,et al.  Function of osteocytes in bone , 1994, Journal of cellular biochemistry.

[159]  P. Worlock,et al.  The prevention of infection in open fractures: an experimental study of the effect of fracture stability. , 1994, Injury.

[160]  T. Hefferan,et al.  Structure and molecular regulation of bone matrix proteins , 1993, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[161]  R. Hoffmann,et al.  The Incidence of Osteitis in Open Fractures: An Analysis of 948 Open Fractures (A Review of the Hannover Experience) , 1993, Journal of orthopaedic trauma.

[162]  V. Rosen,et al.  THE HEALING OF SEGMENTAL BONE DEFECTS, INDUCED BY RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN (rhBMP‐2): A RADIOGRAPHIC, HISTOLOGICAL, AND BIOMECHANICAL STUDY IN RATS , 1993 .

[163]  V. Rosen,et al.  The healing of segmental bone defects, induced by recombinant human bone morphogenetic protein (rhBMP-2). A radiographic, histological, and biomechanical study in rats. , 1992, The Journal of bone and joint surgery. American volume.

[164]  R. Gustilo,et al.  The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. , 1991, The Journal of bone and joint surgery. American volume.

[165]  T. Martin,et al.  Origin of osteoclasts: mature monocytes and macrophages are capable of differentiating into osteoclasts under a suitable microenvironment prepared by bone marrow-derived stromal cells. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[166]  M. Glimcher The nature of the mineral component of bone and the mechanism of calcification. , 1987, Instructional course lectures.

[167]  K. Julshamn,et al.  NEUROPATHY CAUSED BY SILVER ABSORPTION FROM ARTHROPLASTY CEMENT , 1985, The Lancet.

[168]  D. N. Williams,et al.  Problems in the management of type III (severe) open fractures: a new classification of type III open fractures. , 1984, The Journal of trauma.

[169]  J. Spadaro,et al.  Silver antibacterial bone cement. Comparison with gentamicin in experimental osteomyelitis. , 1982, Clinical orthopaedics and related research.

[170]  R. Gustilo,et al.  OTD classic article review - Gustillo RB, Anderson JT (1976) Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analyses , 2002, The Journal of bone and joint surgery. American volume.

[171]  J. Harvey,et al.  The role of antibiotics in the management of open fractures. , 1974, The Journal of bone and joint surgery. American volume.

[172]  R. Dubos The micro-environment of inflammation or Metchnikoff revisited. , 1955, Lancet.