Classification of Magnetic Nanoparticle Systems—Synthesis, Standardization and Analysis Methods in the NanoMag Project

This study presents classification of different magnetic single- and multi-core particle systems using their measured dynamic magnetic properties together with their nanocrystal and particle sizes. The dynamic magnetic properties are measured with AC (dynamical) susceptometry and magnetorelaxometry and the size parameters are determined from electron microscopy and dynamic light scattering. Using these methods, we also show that the nanocrystal size and particle morphology determines the dynamic magnetic properties for both single- and multi-core particles. The presented results are obtained from the four year EU NMP FP7 project, NanoMag, which is focused on standardization of analysis methods for magnetic nanoparticles.

[1]  Andrea Prieto Astalan,et al.  Sensitive High Frequency AC Susceptometry in Magnetic Nanoparticle Applications , 2010 .

[2]  F. Ludwig,et al.  Determination of core and hydrodynamic size distributions of CoFe2O4 nanoparticle suspensions using ac susceptibility measurements , 2010 .

[3]  Dag Winkler,et al.  A new approach for bioassays based on frequency- and time-domain measurements of magnetic nanoparticles. , 2010, Biosensors & bioelectronics.

[4]  Kannan M. Krishnan,et al.  Size-Dependent Relaxation Properties of Monodisperse Magnetite Nanoparticles Measured Over Seven Decades of Frequency by AC Susceptometry , 2013, IEEE Transactions on Magnetics.

[5]  Frank Ludwig,et al.  Magnetorelaxometry of magnetic nanoparticles in magnetically unshielded environment utilizing a differential fluxgate arrangement , 2005 .

[6]  K. Krishnan Biomedical Nanomagnetics: A Spin Through Possibilities in Imaging, Diagnostics, and Therapy , 2010, IEEE Transactions on Magnetics.

[7]  L. Trahms,et al.  Magnetic, Structural, and Particle Size Analysis of Single- and Multi-Core Magnetic Nanoparticles , 2014, IEEE Transactions on Magnetics.

[8]  F. Ludwig Characterization of Magnetic Core‐Shell Nanoparticle Suspensions Using AC Susceptibility for Frequencies up to 1 MHz , 2010 .

[9]  J. Marco,et al.  Uniform and water stable magnetite nanoparticles with diameters around the monodomain–multidomain limit , 2008 .

[10]  Frank Ludwig,et al.  Self-consistent magnetic properties of magnetite tracers optimized for magnetic particle imaging measured by ac susceptometry, magnetorelaxometry and magnetic particle spectroscopy. , 2014, Journal of magnetism and magnetic materials.

[11]  J. Marco,et al.  Ultrasmall iron oxide nanoparticles for biomedical applications: improving the colloidal and magnetic properties. , 2012, Langmuir : the ACS journal of surfaces and colloids.

[12]  F. Ludwig,et al.  Effective particle magnetic moment of multi-core particles , 2015 .

[13]  Q. Pankhurst,et al.  Synthesis methods to prepare single- and multi-core iron oxide nanoparticles for biomedical applications. , 2015, Dalton transactions.

[14]  F. Ludwig,et al.  Characterization of magnetic core–shell nanoparticles by fluxgate magnetorelaxometry, ac susceptibility, transmission electron microscopy and photon correlation spectroscopy—A comparative study , 2009 .

[15]  Lee Makowski,et al.  Biological sensing with magnetic nanoparticles using brownian relaxation (invited) , 2005 .

[16]  Q. Pankhurst,et al.  Applications of magnetic nanoparticles in biomedicine , 2003 .