Alcohol Abuse and Alcoholic Liver Cirrhosis Leading to Spontaneous Muscle Hematoma: An Event Fraught with Danger

Alcohol abuse is associated with both potentiating and antagonizing hemostatic states. Liver cirrhosis is an independent causal factor for many bleeding complications. The long-term effects of alcohol abuse coupled with advanced liver cirrhosis are additive in favor of bleeding. We report the case of a patient with a history of alcohol abuse who presented with liver cirrhosis and nontraumatic muscle hematoma diagnosed as a spontaneous hematoma of the gastrocnemius muscle. He was managed conservatively with infusions of fresh frozen plasma and platelets, which resulted in resolution of the hematoma. The pathogenesis of ‘spontaneous' muscle hematoma remains anecdotal, but since it is reported in patients on anticoagulant therapy or with hemostatic disorders, it is hypothetically related to severely deranged coagulation. Here we review the relevant literature pertaining to the pathogenesis, presentation and treatment options available for treating this often fatal complication of bleeding diatheses.

[1]  H. Min,et al.  Three Cases of Spontaneous Muscle Hematoma in Alcoholic Liver Cirrhosis , 2014 .

[2]  A. Singal,et al.  Recent trends in the epidemiology of alcoholic liver disease , 2013, Clinical liver disease.

[3]  S. Yamashita,et al.  Iliopsoas Muscle Hematoma Secondary to Alcoholic Liver Cirrhosis , 2012, Case Reports in Gastroenterology.

[4]  L. Siopa,et al.  [Spontaneous ileopsoas hematoma: a rare and lethal complication of liver cirrhosis]. , 2012, Acta medica portuguesa.

[5]  A. Burroughs,et al.  Hemostasis and thrombosis in patients with liver disease: the ups and downs. , 2010, Journal of hepatology.

[6]  N. Salemis,et al.  Diagnostic evaluation and management of patients with rectus sheath hematoma. A retrospective study. , 2010, International journal of surgery.

[7]  N. Yamakita,et al.  Muscle hematoma: a critically important complication of alcoholic liver cirrhosis. , 2009, World Journal of Gastroenterology.

[8]  Teruo Sakamoto,et al.  A case of idiopathic iliopsoas hemorrhage in an alcohol abuser effectively treated with vitamin K therapy , 2009 .

[9]  S. M. Kim,et al.  Spontaneous rupture of the lateral thoracic artery in patients with liver cirrhosis , 2008, The Korean journal of internal medicine.

[10]  Y. Shih,et al.  Spontaneous intracranial hemorrhage in cirrhotic patients , 2008, Clinical Neurology and Neurosurgery.

[11]  G. Bartal,et al.  Transcatheter arterial embolisation in anticoagulant‐related haematoma – a current therapeutic option: a report of four patients and review of the literature , 2007, International journal of clinical practice.

[12]  A. D. Di Bisceglie,et al.  Spontaneous retroperitoneal and rectus muscle hemorrhage as a potentially lethal complication of cirrhosis , 2006, Liver international : official journal of the International Association for the Study of the Liver.

[13]  K. Reddy,et al.  Coagulation disorders and hemostasis in liver disease: Pathophysiology and critical assessment of current management , 2006, Hepatology.

[14]  Chihiro Hasegawa,et al.  [A case of alcoholic liver cirrhosis associated with intramuscular hematoma]. , 2006, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

[15]  P. Mueller,et al.  Rectus Sheath Hematoma: Review of 126 Cases at a Single Institution , 2006, Medicine.

[16]  M. Laposata,et al.  Effects of alcohol on hemostasis. , 2005, American journal of clinical pathology.

[17]  Y. Hama,et al.  Spontaneous rupture of the lumbar artery. , 2004, Internal medicine.

[18]  Yoshinobu Sato,et al.  Liver transplantation in an endostage cirrhosis patient with abdominal compartment syndrome following a spontaneous rectus sheath hematoma , 2004, Journal of gastroenterology and hepatology.

[19]  Y. Hiasa,et al.  A case of alcoholic liver cirrhosis complicated with iliopsoas hematoma:difficulty in discriminating the diagnosis of progressive anemia , 2004 .

[20]  H. Kawakami,et al.  [Two cases of alcoholic liver cirrhosis associated with intramuscular hematoma]. , 2002, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

[21]  R. D'Agostino,et al.  Alcohol Consumption and Hemostatic Factors: Analysis of the Framingham Offspring Cohort , 2001, Circulation.

[22]  N. Kawai,et al.  [A case of iliopsoas hematoma associated with liver cirrhosis, management by transcatheter arterial embolization]. , 2000, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

[23]  N. Yamakita,et al.  [A case of idiopathic iliopsoas hematoma associated with liver cirrhosis]. , 1998, Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology.

[24]  A. Herrick,et al.  Bilateral rectus sheath haematoma complicating alcoholic liver disease. , 1991, The British journal of clinical practice.