Self-regulation in ADHD: the role of error processing.

Attention-deficit hyperactivity disorder (ADHD) is characterized by persistent and impairing developmentally inappropriate levels of inattention, hyperactivity, and impulsivity. Such behavioral dysregulation may be a consequence of deficits in self-monitoring or adaptive control, both of which are required for adaptive behavior. Processing of contextual demands, ongoing monitoring of one's behavior to evaluate whether it is appropriate for a particular situation, and adjusting behavior when it is suboptimal are components of self-regulation. This review examines and integrates the emerging literature on error-processing and adaptive control as components of self-regulation into the prominent etiological theories of ADHD. Available data on error-processing, as reflected in event-related potentials (ERN and Pe) and behavioral performance, suggest that both early error detection and later error-evaluation may be diminished in ADHD, thereby interfering with adaptive control processes. However, variability in results limit broad conclusions, particularly for early error detection. A range of methodological issues, including ERP parameters and sample and task characteristics, likely contribute to this variability, and recommendations for future work are presented. The emerging literature on error-processing and adaptive control informs etiological theories of ADHD in general and may provide a method for testing self-regulation models in particular.

[1]  C. Carter,et al.  The anterior cingulate as a conflict monitor: fMRI and ERP studies , 2002, Physiology & Behavior.

[2]  W. F. Caul,et al.  Attention deficit disorder with hyperactivity: a specific hypothesis of reward dysfunction. , 1987, Journal of the American Academy of Child and Adolescent Psychiatry.

[3]  M. Beauregard.  Consciousness, Emotional Self-Regulation and the Brain , 2004 .

[4]  Maarten A. S. Boksem,et al.  Error-related ERP components and individual differences in punishment and reward sensitivity , 2006, Brain Research.

[5]  M. Posner,et al.  Developing mechanisms of self-regulation , 2000, Development and Psychopathology.

[6]  Ann-Christine Ehlis,et al.  Altered response control and anterior cingulate function in attention-deficit/hyperactivity disorder boys , 2004, Clinical Neurophysiology.

[7]  V. Russell,et al.  A dynamic developmental theory of attention-deficit/hyperactivity disorder (ADHD) predominantly hyperactive/impulsive and combined subtypes. , 2005, The Behavioral and brain sciences.

[8]  John J. Foxe,et al.  The neural correlates of deficient error awareness in attention-deficit hyperactivity disorder (ADHD) , 2009, Neuropsychologia.

[9]  B. Pennington.  Toward a New Neuropsychological Model of Attention-Deficit/Hyperactivity Disorder: Subtypes and Multiple Deficits , 2005, Biological Psychiatry.

[10]  R. Dahl,et al.  Increased error-related negativity (ERN) in childhood anxiety disorders: ERP and source localization. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[11]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[12]  A. A. Wijers,et al.  Error and feedback processing in children with ADHD and children with Autistic Spectrum Disorder: An EEG event-related potential study , 2008, Clinical Neurophysiology.

[13]  E. Mahone,et al.  The neurobiological profile of girls with ADHD. , 2008, Developmental disabilities research reviews.

[14]  C. Patrick,et al.  Externalizing Psychopathology and the Error-Related Negativity , 2007, Psychological science.

[15]  S. Segalowitz,et al.  ERP correlates of error monitoring in 10-year olds are related to socialization , 2005, Biological Psychology.

[16]  J. Sergeant,et al.  Heart rate and reinforcement sensitivity in ADHD. , 2007, Journal of child psychology and psychiatry, and allied disciplines.

[17]  M. Posner,et al.  Cognitive and emotional influences in anterior cingulate cortex , 2000, Trends in Cognitive Sciences.

[18]  Robert F. Simons,et al.  Anxiety and error-related brain activity , 2003, Biological Psychology.

[19]  Sidney J Segalowitz,et al.  Development of Response-Monitoring ERPs in 7- to 25-Year-Olds , 2004, Developmental neuropsychology.

[20]  P. Zelazo,et al.  Neurophysiological mechanisms of emotion regulation for subtypes of externalizing children , 2007, Development and Psychopathology.

[21]  R. Barry,et al.  A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials , 2003, Clinical Neurophysiology.

[22]  Joseph A. Sergeant,et al.  Modeling Attention-Deficit/Hyperactivity Disorder: A Critical Appraisal of the Cognitive-Energetic Model , 2004, Biological Psychiatry.

[23]  Herbert C. Quay,et al.  Handbook of disruptive behavior disorders , 1999 .

[24]  Sarah L. Master,et al.  Neurocognitive components of the behavioral inhibition and activation systems: implications for theories of self-regulation. , 2007, Psychophysiology.

[25]  D. Tucker,et al.  Electrophysiological Responses to Errors and Feedback in the Process of Action Regulation , 2003, Psychological science.

[26]  R. Simons,et al.  Error-related psychophysiology and negative affect , 2004, Brain and Cognition.

[27]  C. Braun,et al.  Event-Related Brain Potentials Following Incorrect Feedback in a Time-Estimation Task: Evidence for a Generic Neural System for Error Detection , 1997, Journal of Cognitive Neuroscience.

[28]  J. Meere,et al.  Information Processing and Energetic Factors in Attention-Deficit/Hyperactivity Disorder , 1999 .

[29]  S. Segalowitz,et al.  Development of Error‐Monitoring Event‐Related Potentials in Adolescents , 2004, Annals of the New York Academy of Sciences.

[30]  D. Gozal,et al.  Attention deficit hyperactivity disorder : from genes to patients , 2005 .

[31]  Jan R. Wiersema,et al.  ERP correlates of impaired error monitoring in children with ADHD , 2005, Journal of Neural Transmission.

[32]  T R Zentall,et al.  Optimal stimulation: a model of disordered activity and performance in normal and deviant children. , 1983, Psychological bulletin.

[33]  J. Meere.  State Regulation and Attention Deficit Hyperactivity Disorder , 2005 .

[34]  Thérèse J. M. Overbeek,et al.  Dissociable Components of Error Processing on the Functional Significance of the Pe Vis-à-vis the Ern/ne Performance Monitoring Processes Reflected in the Ne and Pe Review of Studies That Report Both Ne and Pe: Associations and Dissociations Pharmacological Effects , 2022 .

[35]  Sidney J Segalowitz,et al.  The error-related negativity as a state and trait measure: motivation, personality, and ERPs in response to errors. , 2004, Psychophysiology.

[36]  B. Pennington,et al.  Validity of the Executive Function Theory of Attention-Deficit/Hyperactivity Disorder: A Meta-Analytic Review , 2005, Biological Psychiatry.

[37]  W. Gehring,et al.  Action-Monitoring Dysfunction in Obsessive-Compulsive Disorder , 2000, Psychological science.

[38]  N. Yeung,et al.  On the ERN and the significance of errors. , 2005, Psychophysiology.

[39]  J. Sergeant.  The cognitive-energetic model: an empirical approach to Attention-Deficit Hyperactivity Disorder , 2000, Neuroscience & Biobehavioral Reviews.

[40]  L. Jonkman,et al.  Methylphenidate improves deficient error evaluation in children with ADHD: An event-related brain potential study , 2007, Biological Psychology.

[41]  J. Meere,et al.  Motor control and state regulation in children with ADHD: a cardiac response study , 2000, Biological Psychology.

[42]  Jeff T. Larsen,et al.  The good, the bad and the neutral: Electrophysiological responses to feedback stimuli , 2006, Brain Research.

[43]  C Leth-Steensen,et al.  Mean response times, variability, and skew in the responding of ADHD children: a response time distributional approach. , 2000, Acta psychologica.

[44]  Jonathan D. Cohen,et al.  Decision making, the P3, and the locus coeruleus-norepinephrine system. , 2005, Psychological bulletin.

[45]  B. Pennington.  From single to multiple deficit models of developmental disorders , 2006, Cognition.

[46]  J. Meere,et al.  The Development of State Regulation in Normal Children: An Indirect Comparison With Children With ADHD , 1999 .

[47]  V. Douglas.  Cognitive Control Processes in Attention Deficit/Hyperactivity Disorder , 1999 .

[48]  M. Falkenstein,et al.  Neural activity associated with executive functions in adolescents with attention-deficit/hyperactivity disorder (ADHD). , 2009, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[49]  H. Bogte,et al.  Heart Rate Variability and Sustained Attention in ADHD Children , 1999, Journal of abnormal child psychology.

[50]  Clay B. Holroyd,et al.  The neural basis of human error processing: reinforcement learning, dopamine, and the error-related negativity. , 2002, Psychological review.

[51]  B. Horta,et al.  The worldwide prevalence of ADHD: a systematic review and metaregression analysis. , 2007, The American journal of psychiatry.

[52]  Jutta Kray,et al.  Developmental differences in learning and error processing: evidence from ERPs. , 2009, Psychophysiology.

[53]  G. Hajcak,et al.  The error-related negativity (ERN) and psychopathology: toward an endophenotype. , 2008, Clinical psychology review.

[54]  R. Simons,et al.  Error-related brain activity in obsessive–compulsive undergraduates , 2002, Psychiatry Research.

[55]  B. Wetering,et al.  Error-processing deficits in patients with cocaine dependence , 2007, Biological Psychology.

[56]  Adrian R. Willoughby,et al.  The Medial Frontal Cortex and the Rapid Processing of Monetary Gains and Losses , 2002, Science.

[57]  J. Hohnsbein,et al.  ERP components on reaction errors and their functional significance: a tutorial , 2000, Biological Psychology.

[58]  Jay Brand,et al.  File Drawer Problem , 2022, The SAGE Encyclopedia of Research Design.

[59]  G. Logan,et al.  Impulsivity and Inhibitory Control , 1997 .

[60]  E. Barratt,et al.  Reduced punishment sensitivity in neural systems of behavior monitoring in impulsive individuals , 2006, Neuroscience Letters.

[61]  J. Sergeant,et al.  Motivational effects on motor timing in attention-deficit/hyperactivity disorder. , 2005, Journal of the American Academy of Child and Adolescent Psychiatry.

[62]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[63]  D. Tucker,et al.  5. Self-regulation by the medial frontal cortex: Limbic representation of motive set-points , 2004 .

[64]  Joel T. Nigg,et al.  Neuropsychologic Theory and Findings in Attention-Deficit/Hyperactivity Disorder: The State of the Field and Salient Challenges for the Coming Decade , 2005, Biological Psychiatry.

[65]  R. Simons,et al.  To err is autonomic: error-related brain potentials, ANS activity, and post-error compensatory behavior. , 2003, Psychophysiology.

[66]  J. Nigg,et al.  Single dissociation findings of ADHD deficits in vigilance but not anterior or posterior attention systems. , 2006, Neuropsychology.

[67]  Marty G. Woldorff,et al.  Abnormal Brain Activity Related to Performance Monitoring and Error Detection in Children with ADHD , 2005, Cortex.

[68]  Chris Hollis,et al.  Electrophysiological indices of abnormal error-processing in adolescents with attention deficit hyperactivity disorder (ADHD). , 2010, Journal of child psychology and psychiatry, and allied disciplines.

[69]  J. Allen,et al.  Error monitoring during reward and avoidance learning in high- and low-socialized individuals. , 2000, Psychophysiology.

[70]  C. Eriksen,et al.  Effects of noise letters upon the identification of a target letter in a nonsearch task , 1974 .

[71]  J. Fletcher,et al.  Error-related event-related potentials in children with attention-deficit hyperactivity disorder, oppositional defiant disorder, reading disorder, and math disorder , 2007, Biological Psychology.

[72]  Dirk J. Heslenfeld,et al.  Adaptive control deficits in attention-deficit/hyperactivity disorder (ADHD): The role of error processing , 2007, Psychiatry Research.

[73]  V. Douglas,et al.  Effects of reward and nonreward on frustration and attention in attention deficit disorder , 1994, Journal of abnormal child psychology.

[74]  P. Rabbitt.  Errors and error correction in choice-response tasks. , 1966, Journal of experimental psychology.

[75]  J. Kuntsi,et al.  Hyperactivity in Children: A Focus on Genetic Research and Psychological Theories , 2000, Clinical child and family psychology review.

[76]  Maarten A. S. Boksem,et al.  Mental fatigue, motivation and action monitoring , 2006, Biological Psychology.

[77]  H. Geurts,et al.  The top and the bottom of ADHD: a neuropsychological perspective , 2003, Neuroscience & Biobehavioral Reviews.

[78]  D. Meyer,et al.  A Neural System for Error Detection and Compensation , 1993 .

[79]  F. Castellanos,et al.  Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes , 2002, Nature Reviews Neuroscience.

[80]  P. Snyder,et al.  Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder , 2006, Neuroscience & Biobehavioral Reviews.

[81]  Gordon D Logan,et al.  Evidence for an Error Monitoring Deficit in Attention Deficit Hyperactivity Disorder , 2004, Journal of abnormal child psychology.

[82]  M. Posner,et al.  Developing mechanisms of temperamental effortful control. , 2003, Journal of personality.

[83]  R. Barkley.  Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. , 1997, Psychological bulletin.

[84]  H. Quay.  Inhibition and Attention Deficit Hyperactivity Disorder , 1997, Journal of abnormal child psychology.

[85]  K. R. Ridderinkhof,et al.  Error-related brain potentials are differentially related to awareness of response errors: evidence from an antisaccade task. , 2001, Psychophysiology.

[86]  Chong-huai Yan,et al.  The brain regulation mechanism of error monitoring in impulsive children with ADHD—An analysis of error related potentials , 2009, Neuroscience Letters.

[87]  J. Brehm,et al.  The intensity of motivation. , 1989, Annual review of psychology.

[88]  M. Posner,et al.  Localization of a Neural System for Error Detection and Compensation , 1994 .

[89]  Shani Shalgi,et al.  On the positive side of error processing: error‐awareness positivity revisited , 2009, The European journal of neuroscience.

[90]  J. Gray,et al.  Précis of The neuropsychology of anxiety: An enquiry into the functions of the septo-hippocampal system , 1982, Behavioral and Brain Sciences.

[91]  Katherine A. Johnson,et al.  Behavioral and Brain Functions , 2009 .

[92]  T. Banaschewski,et al.  Action Monitoring in Boys With Attention-Deficit/Hyperactivity Disorder, Their Nonaffected Siblings, and Normal Control Subjects: Evidence for an Endophenotype , 2008, Biological Psychiatry.

[93]  J. Nigg.  What causes ADHD? : understanding what goes wrong and why , 2006 .

[94]  William E. Pelham,et al.  Evidence-Based Psychosocial Treatments for Attention-Deficit/Hyperactivity Disorder , 2008, Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53.

[95]  E. Sonuga-Barke,et al.  The dual pathway model of AD/HD: an elaboration of neuro-developmental characteristics , 2003, Neuroscience & Biobehavioral Reviews.

[96]  J. Buitelaar,et al.  Comparing the efficacy of stimulants for ADHD in children and adolescents using meta-analysis , 2010, European Child & Adolescent Psychiatry.

[97]  R. Rosenthal.  The file drawer problem and tolerance for null results , 1979 .

[98]  Joseph A. Sergeant,et al.  What happens after a hyperactive child commits an error? , 1988, Psychiatry Research.

[99]  J. Hohnsbein,et al.  Effects of crossmodal divided attention on late ERP components. II. Error processing in choice reaction tasks. , 1991, Electroencephalography and clinical neurophysiology.

[100]  Clay B. Holroyd,et al.  Electrophysiological evidence of atypical motivation and reward processing in children with attention-deficit hyperactivity disorder , 2008, Neuropsychologia.

[101]  L. M. Bloomingdale.  Attention deficit disorder : identification, course, and rationale , 1985 .

[102]  S. Segalowitz,et al.  Charting the maturation of the frontal lobe: An electrophysiological strategy , 2004, Brain and Cognition.

[103]  A. Sanders.  Towards a model of stress and human performance. , 1983, Acta psychologica.

[104]  A. A. Wijers,et al.  Methylphenidate improves diminished error and feedback sensitivity in ADHD: An Evoked Heart Rate analysis , 2009, Biological Psychology.

[105]  D. Tucker,et al.  Medial Frontal Cortex in Action Monitoring , 2000, The Journal of Neuroscience.

[106]  Subcommittee on Attention-Deficit,et al.  Clinical practice guideline: treatment of the school-aged child with attention-deficit/hyperactivity disorder. , 2001, Pediatrics.

[107]  Jaap Oosterlaan,et al.  The impact of reinforcement contingencies on AD/HD: a review and theoretical appraisal. , 2005, Clinical psychology review.

[108]  J. Nigg,et al.  Child ADHD and personality/temperament traits of reactive and effortful control, resiliency, and emotionality. , 2006, Journal of child psychology and psychiatry, and allied disciplines.

[109]  T. Banaschewski,et al.  Performance monitoring is altered in adult ADHD: A familial event-related potential investigation , 2009, Neuropsychologia.

[110]  H. Roeyers,et al.  State Regulation in Adult ADHD: An Event-related Potential Study , 2006, Journal of clinical and experimental neuropsychology.

[111]  Jan R. Wiersema,et al.  Error monitoring in children with ADHD or reading disorder: An event-related potential study , 2010, Biological Psychology.

[112]  S. Luck.  An Introduction to the Event-Related Potential Technique , 2005 .