Insulin resistance and the metabolism of branched-chain amino acids in humans

[1]  V. Mootha,et al.  Metabolite profiles and the risk of developing diabetes , 2011, Nature Medicine.

[2]  B. Rasmussen,et al.  Essential amino acid sensing, signaling, and transport in the regulation of human muscle protein metabolism , 2011, Current opinion in clinical nutrition and metabolic care.

[3]  E. Tai,et al.  Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men , 2010, Diabetologia.

[4]  William E. Kraus,et al.  Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women , 2009, Diabetes Care.

[5]  P. Ping,et al.  Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells. , 2009, The Journal of clinical investigation.

[6]  Svati H Shah,et al.  A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. , 2009, Cell metabolism.

[7]  K. Nair,et al.  Functional impact of high protein intake on healthy elderly people. , 2008, American journal of physiology. Endocrinology and metabolism.

[8]  Ru Wei,et al.  Metabolic profiling of the human response to a glucose challenge reveals distinct axes of insulin sensitivity , 2008, Molecular systems biology.

[9]  B. Rutkowski,et al.  Serum concentration of amino acids versus nutritional status in hemodialysis patients. , 2008, Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.

[10]  Leena Peltonen,et al.  Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity , 2008, PLoS medicine.

[11]  Pengxiang She,et al.  Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism. , 2007, American journal of physiology. Endocrinology and metabolism.

[12]  Stuart M Phillips,et al.  Exercise training increases branched-chain oxoacid dehydrogenase kinase content in human skeletal muscle. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[13]  D. Chuang,et al.  Structure of the Subunit Binding Domain and Dynamics of the Di-domain Region from the Core of Human Branched Chain α-Ketoacid Dehydrogenase Complex* , 2006, Journal of Biological Chemistry.

[14]  W. Mitch,et al.  Effect of bicarbonate on muscle protein in patients receiving hemodialysis. , 2006, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[15]  W. Saris,et al.  Co-ingestion of a protein hydrolysate with or without additional leucine effectively reduces postprandial blood glucose excursions in Type 2 diabetic men. , 2006, The Journal of nutrition.

[16]  R. Gougeon,et al.  The greater contribution of gluconeogenesis to glucose production in obesity is related to increased whole-body protein catabolism. , 2006, Diabetes.

[17]  R. Gougeon,et al.  Whole-body protein anabolic response is resistant to the action of insulin in obese women , 2005 .

[18]  G. Marchesini,et al.  Branched-chain amino acids and alanine as indices of the metabolic control in Type 1 (insulin-dependent) and Type 2 (non-insulin-dependent) diabetic patients , 1982, Diabetologia.

[19]  D. Bloesch,et al.  Effects of medium- and long-chain fatty acids on whole body leucine and glucose kinetics in man. , 2002, Metabolism: clinical and experimental.

[20]  E. Verrina,et al.  Free amino acids in plasma, red blood cells, polymorphonuclear leukocytes, and muscle in normal and uraemic children. , 2002, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[21]  Y. Boirie,et al.  Alterations of protein metabolism by metabolic acidosis in children with chronic renal failure. , 2000, Kidney international.

[22]  D. Matthews,et al.  Splanchnic bed utilization of enteral α-ketoisocaproate in humans , 1999 .

[23]  R. Mak Effect of metabolic acidosis on branched-chain amino acids in uremia , 1999, Pediatric Nephrology.

[24]  D. Matthews,et al.  Splanchnic bed utilization of enteral alpha-ketoisocaproate in humans. , 1999, Metabolism: clinical and experimental.

[25]  R. Harris,et al.  A molecular model of human branched-chain amino acid metabolism. , 1998, The American journal of clinical nutrition.

[26]  C. Stanley,et al.  Hyperinsulinism and hyperammonemia in infants with regulatory mutations of the glutamate dehydrogenase gene. , 1998, The New England journal of medicine.

[27]  N. Deutz,et al.  Nephrology Dialysis Transplantation the Influence of Bicarbonate Supplementation on Plasma Levels of Branched-chain Amino Acids in Haemodialysis Patients with Metabolic Acidosis , 2022 .

[28]  J. Wernerman,et al.  Correction of acidosis in dialysis patients increases branched-chain and total essential amino acid levels in muscle. , 1997, Clinical nephrology.

[29]  R. DeFronzo,et al.  Protein metabolism in human obesity: relationship with glucose and lipid metabolism and with visceral adipose tissue. , 1997, The Journal of clinical endocrinology and metabolism.

[30]  S. Downie,et al.  Correction of acidosis in hemodialysis decreases whole-body protein degradation. , 1997, Journal of the American Society of Nephrology : JASN.

[31]  M. Vettore,et al.  Leucine metabolism and protein dynamics in the human kidney. , 1997, Contributions to nephrology.

[32]  M. Vettore,et al.  Kidney, splanchnic, and leg protein turnover in humans. Insight from leucine and phenylalanine kinetics. , 1996, The Journal of clinical investigation.

[33]  G. Deferrari,et al.  Muscle protein turnover in chronic renal failure patients with metabolic acidosis or normal acid-base balance. , 1996, Mineral and electrolyte metabolism.

[34]  G. Deferrari,et al.  Skeletal muscle protein synthesis and degradation in patients with chronic renal failure. , 1994, Kidney international.

[35]  D. Matthews,et al.  Splanchnic bed utilization of glutamine and glutamic acid in humans. , 1993, The American journal of physiology.

[36]  G. Deferrari,et al.  Peripheral metabolism of branched-chain keto acids in patients with chronic renal failure. , 1993, Mineral and electrolyte metabolism.

[37]  E. Barrett,et al.  Insulin sensitivity of protein and glucose metabolism in human forearm skeletal muscle. , 1992, The Journal of clinical investigation.

[38]  C. Scrimgeour,et al.  Ammonium chloride-induced acidosis increases protein breakdown and amino acid oxidation in humans. , 1992, The American journal of physiology.

[39]  P. Fürst,et al.  Branched-chain amino acids and branched-chain ketoacids in uremia. , 1992, Contributions to nephrology.

[40]  G. Farshidfar,et al.  Essential branched-chain amino acids and α-ketoanalogues in haemodialysis patients , 1992 .

[41]  G. Farshidfar,et al.  Essential branched-chain amino acids and alpha-ketoanalogues in haemodialysis patients. , 1992, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[42]  G. Deferrari,et al.  Muscle protein turnover and amino acid metabolism in patients with chronic renal failure. , 1992, Mineral and electrolyte metabolism.

[43]  D. Bloesch,et al.  Effect of acute acidosis and alkalosis on leucine kinetics in man. , 1992, Clinical physiology.

[44]  A. Körner,et al.  Changes in plasma and urinary amino acid levels during diabetic ketoacidosis in children. , 1991, Diabetes research and clinical practice.

[45]  P. Déchelotte,et al.  Role of leucine as a precursor of glutamine alpha-amino nitrogen in vivo in humans. , 1991, The American journal of physiology.

[46]  R. Wurtman,et al.  Differential effects of insulin resistance on leucine and glucose kinetics in obesity. , 1991, Metabolism: clinical and experimental.

[47]  D. Halliday,et al.  Influence of glucagon on protein and leucine metabolism: A study in fasting man with induced insuiin resistance , 1990, The British journal of surgery.

[48]  P. Fürst,et al.  Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition. , 1990, Kidney international.

[49]  M. Plauth,et al.  Characteristic pattern of free amino acids in plasma and skeletal muscle in stable hepatic cirrhosis. , 1990, Hepato-gastroenterology.

[50]  M. Walser,et al.  Branched-chain-ketoacid metabolism in patients with chronic renal failure. , 1989, The American journal of clinical nutrition.

[51]  F. Horber,et al.  Contribution of Insulin Resistance to Catabolic Effect of Prednisone on Leucine Metabolism in Humans , 1989, Diabetes.

[52]  Y. Maruhama,et al.  Rapid changes in urinary serine and branched-chain amino acid excretion among diabetic patients during insulin treatment. , 1988, Diabetes research and clinical practice.

[53]  R. DeFronzo,et al.  Influence of hyperinsulinaemia on intracellular amino acid levels and amino acid exchange across splanchnic and leg tissues in uraemia. , 1988, Clinical science.

[54]  P. Schauder,et al.  Oxidation of leucine in human lymphocytes. , 1987, Scandinavian journal of clinical and laboratory investigation.

[55]  G. Marchesini,et al.  Plasma clearances of branched-chain amino acids in control subjects and in patients with cirrhosis. , 1987, Journal of hepatology.

[56]  A. Avogaro,et al.  Type I diabetes is characterized by insulin resistance not only with regard to glucose, but also to lipid and amino acid metabolism. , 1986, The Journal of clinical endocrinology and metabolism.

[57]  G. Biolo,et al.  Defective suppression by insulin of leucine-carbon appearance and oxidation in type 1, insulin-dependent diabetes mellitus. Evidence for insulin resistance involving glucose and amino acid metabolism. , 1986, The Journal of clinical investigation.

[58]  R. DeFronzo,et al.  Removal of infused amino acids by splanchnic and leg tissues in humans. , 1986, The American journal of physiology.

[59]  G. Deferrari,et al.  Leg metabolism of amino acids and ammonia in patients with chronic renal failure. , 1985, Clinical science.

[60]  U. Langenbeck,et al.  Serum branched chain amino and keto acid response to fasting in humans. , 1985, Metabolism: clinical and experimental.

[61]  U. Langenbeck,et al.  Evidence for Valine Intolerance in Patients with Cirrhosis , 1984, Hepatology.

[62]  G. Marchesini,et al.  Insulin-dependent metabolism of branched-chain amino acids in obesity. , 1984, Metabolism: clinical and experimental.

[63]  U. Langenbeck,et al.  Serum branched-chain amino and keto acid response to a protein-rich meal in man. , 1984, Annals of nutrition & metabolism.

[64]  G. Marchesini,et al.  Effect of Euglycemic Insulin Infusion on Plasma Levels of Branched‐Chain Amino Acids in Cirrhosis , 2007, Hepatology.

[65]  G. Deferrari,et al.  Branched-chain amino acid metabolism in chronic renal failure. , 1983, Kidney international. Supplement.

[66]  J. Wahren,et al.  Amino acids in liver disease , 1983, Proceedings of the Nutrition Society.

[67]  G. Marchesini,et al.  Plasma amino acid response to protein ingestion in patients with liver cirrhosis. , 1983, Gastroenterology.

[68]  M. Elia,et al.  Effects of ingested steak and infused leucine on forelimb metabolism in man and the fate of the carbon skeletons and amino groups of branched-chain amino acids. , 1983, Clinical science.

[69]  D. Matthaei,et al.  Influence of insulin on blood levels of branched chain keto and amino acids in man. , 1983, Metabolism: clinical and experimental.

[70]  M. Haymond,et al.  Branched Chain Amino Acids as a Major Source of Alanine Nitrogen in Man , 1982, Diabetes.

[71]  G. Ghiggeri,et al.  Renal ammoniagenesis in an early stage of metabolic acidosis in man. , 1982, The Journal of clinical investigation.

[72]  D. J. Millward,et al.  Regulation of leucine metabolism in man: a stable isotope study. , 1981, Science.

[73]  M. Brennan,et al.  Leucine meal increases glutamine and total nitrogen release from forearm muscle. , 1981, The Journal of clinical investigation.

[74]  G. Ghiggeri,et al.  Brain metabolism of amino acids and ammonia in patients with chronic renal insufficiency. , 1981, Kidney international.

[75]  O. Wieland,et al.  Enzymic determination of branched-chain amino acids. , 1981, Clinical chemistry.

[76]  R. DeFronzo,et al.  Insulin resistance in uremia. , 1981, The Journal of clinical investigation.

[77]  J. Wahren,et al.  Influence of leucine on arterial concentrations and regional exchange of amino acids in healthy subjects. , 1980, Clinical science.

[78]  T. Shows,et al.  Branched-chain aminotransferase deficiency in Chinese hamster cells complemented by two independent genes on human chromosomes 12 and 19 , 1980, Somatic cell genetics.

[79]  R. DeFronzo,et al.  Amino acid metabolism in uremia: insights gained from normal and diabetic man. , 1980, The American journal of clinical nutrition.

[80]  D. Matthaei,et al.  Blood levels of branched-chain amino acids and alpha-ketoacids in uremic patients given keto analogues of essential amino acids. , 1980, The American journal of clinical nutrition.

[81]  G. Garibotto,et al.  Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency. , 1980, The Journal of clinical investigation.

[82]  R. DeFronzo,et al.  Glucose intolerance following chronic metabolic acidosis in man. , 1979, The American journal of physiology.

[83]  J. Kopple,et al.  Valine metabolism in normal and chronically uremic man. , 1978, The American journal of clinical nutrition.

[84]  W. A. Müller,et al.  Blood amine acid levels in patients with insulin excess (functioning insulinoma) and insulin deficiency (diabetic ketosis). , 1978, Metabolism: clinical and experimental.

[85]  後藤 町子 Isozyme Patterns of Branched-chain Amino Acid Transaminase in Human Tissues and Tumors , 1978 .

[86]  M. Goto,et al.  Isozyme patterns of branched-chain amino acid transaminase in human tissues and tumors. , 1977, Gan.

[87]  G. De Ferrari,et al.  Effects of metabolic alkalosis, metabolic acidosis and uraemia on whole-body intracellular pH in man. , 1977, Clinical science and molecular medicine.

[88]  W. A. Müller,et al.  Amino acid levels across normal forearm muscle and splanchnic bed after a protein meal. , 1976, The American journal of clinical nutrition.

[89]  P. Felig,et al.  Effect of protein ingestion on splanchnic and leg metabolism in normal man and in patients with diabetes mellitus. , 1976, The Journal of clinical investigation.

[90]  P. Felig Amino acid metabolism in man. , 1975, Annual review of biochemistry.

[91]  P. Felig,et al.  Splanchnic glucose and amino acid metabolism in obesity. , 1974, The Journal of clinical investigation.

[92]  M. Brennan,et al.  Blood Cell and Plasma Amino Acid Levels Across Forearm Muscle During a Protein Meal , 1973, Diabetes.

[93]  E. Cerasi,et al.  Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. , 1972, The Journal of clinical investigation.

[94]  J. Tobin,et al.  Amino acid balance across tissues of the forearm in postabsorptive man. Effects of insulin at two dose levels. , 1969, The Journal of clinical investigation.

[95]  P. Felig,et al.  Plasma amino acid levels and insulin secretion in obesity. , 1969, The New England journal of medicine.

[96]  G F Cahill,et al.  Amino acid metabolism during prolonged starvation. , 1969, The Journal of clinical investigation.

[97]  S. Adibi Influence of dietary deprivations on plasma concentration of free amino acids of man. , 1968, Journal of applied physiology.