Synthesis, Pim kinase inhibitory potencies and in vitro antiproliferative activities of diversely substituted pyrrolo[2,3-a]carbazoles.

[1]  Stefan Knapp,et al.  Synthesis, kinase inhibitory potencies, and in vitro antiproliferative evaluation of new Pim kinase inhibitors. , 2009, Journal of medicinal chemistry.

[2]  G. Bemis,et al.  Structure-based design of 3-aryl-6-amino-triazolo[4,3-b]pyridazine inhibitors of Pim-1 kinase. , 2009, Bioorganic & medicinal chemistry letters.

[3]  S. Diamond,et al.  Toward the development of a potent and selective organoruthenium mammalian sterile 20 kinase inhibitor. , 2009, Journal of medicinal chemistry.

[4]  C. Homon,et al.  Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode. , 2009, Journal of medicinal chemistry.

[5]  Fabrizio Manetti,et al.  Indolyl-pyrrolone as a new scaffold for Pim1 inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[6]  A. Kraft,et al.  Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases. , 2009, Journal of medicinal chemistry.

[7]  Eric F. Johnson,et al.  Isoxazolo[3,4-b]quinoline-3,4(1H,9H)-diones as unique, potent and selective inhibitors for Pim-1 and Pim-2 kinases: chemistry, biological activities, and molecular modeling. , 2008, Bioorganic & medicinal chemistry letters.

[8]  T. Tsuruo,et al.  Pim kinases promote cell cycle progression by phosphorylating and down-regulating p27Kip1 at the transcriptional and posttranscriptional levels. , 2008, Cancer research.

[9]  A. Pierce,et al.  Docking study yields four novel inhibitors of the protooncogene Pim-1 kinase. , 2008, Journal of medicinal chemistry.

[10]  P. Cohen,et al.  The selectivity of protein kinase inhibitors: a further update. , 2007, The Biochemical journal.

[11]  S. Knapp,et al.  Structural analysis identifies imidazo[1,2-b]pyridazines as PIM kinase inhibitors with in vitro antileukemic activity. , 2007, Cancer research.

[12]  I. W. Cheney,et al.  Identification and structure-activity relationships of substituted pyridones as inhibitors of Pim-1 kinase. , 2007, Bioorganic & medicinal chemistry letters.

[13]  M. Lilly,et al.  Characterization of a potent and selective small-molecule inhibitor of the PIM1 kinase , 2007, Molecular Cancer Therapeutics.

[14]  S. Knapp,et al.  Ruthenium half-sandwich complexes bound to protein kinase Pim-1. , 2006, Angewandte Chemie.

[15]  J. Arthur,et al.  Pim kinases phosphorylate multiple sites on Bad and promote 14-3-3 binding and dissociation from Bcl-XL , 2006, BMC Cell Biology.

[16]  S. Knapp,et al.  Structure and Substrate Specificity of the Pim-1 Kinase* , 2005, Journal of Biological Chemistry.

[17]  S. Knapp,et al.  Structural basis of inhibitor specificity of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM-1) kinase. , 2005, Journal of medicinal chemistry.

[18]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[19]  I. Wilson,et al.  Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity. , 2000, European journal of biochemistry.

[20]  David S. Goodsell,et al.  Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function , 1998, J. Comput. Chem..

[21]  J. Rokach,et al.  Regioselective synthesis of acylpyrroles , 1983 .

[22]  L. Cohen,et al.  New histamine and histidine analogs via transformations of the 2-trifluoromethyl group , 1980 .