Immunopathologic responses of silkmoth allergen on primary and secondary lymphoid organs of mice

Silkmoth scales are allergens that cause several disabling hypersensitive lung diseases like asthma and allergic rhinitis in sericulture grainage industrial workers. Immunopathological responses of silkmoth allergen on primary and secondary lymphoid organs were studied in albino mice. Mice were immunized intraperitoneally and then subsequently challenged with silkmoth allergen intranasally. The mice were then evaluated for total serum IgE, eosinophil viability, and culturing of splenocytes in the presence of PHA, eosinophil peroxidase of bone marrow cells and histology of the thymus. The results indicate that the sensitized mice shows increased levels of IgE, decreased splenocyte viability and cell depletion in the thymus, and increased eosinophils in the lungs. The stimulated spleen showed a typical Th 2 pattern in all allergen sensitized animals.