The Acute Effect of a Novel Miso-Type Sauce, Enhanced with a Carotenoid-Rich Extract from Fruit By-Products, on Postprandial Biomarkers of Oxidative Stress and Inflammation

Several fruit by-products may exert a beneficial role on oxidative stress and inflammation modulation, providing essential bioactive components, such as polyphenols and carotenoids. Recently, the potential bioactivity of miso has been reported. The aim of this dietary intervention–clinical study was to evaluate the acute effect of a novel, functional miso-type sauce based on legumes, on postprandial biomarkers of oxidative stress and inflammation. In this randomized, cross-over design, intervention–clinical trial, 14 healthy volunteers, aged 20–30 years old, consumed a rice meal rich in fat and carbohydrates (258 g), containing a legume-based sauce. After a 1-week washout period, the same subjects consumed the same meal, containing the novel fermented miso-type sauce, enhanced with 50% carotenoid-rich, fruit peel extract. Differences in postprandial total plasma antioxidant capacity according to the FRAP method, serum lipids, glucose, uric acid levels, and antithrombotic activity in platelet-rich plasma were evaluated before, 30 min, 1.5 h, and 3 h after consumption. The results showed that, in comparison to the control group, consumption of the novel sauce resulted in a significantly increased total plasma antioxidant capacity 3 h after consumption (p < 0.05). In addition, we observed a significant attenuation of triglycerides concentration increase in the last 1.5 h in the functional group (p < 0.05). A significant decrease in serum aggregation was found at 30 min and 3 h after functional sauce intake in comparison with the baseline (p < 0.05). Finally, LDL-cholesterol concentrations were significantly reduced 3 h after the functional meal consumption, in comparison with baseline values (p < 0.05). The remaining biomarkers did not show statistically significant differences (p > 0.05). Further investigation is needed in order to validate the current results.

[1]  R. Pradhan,et al.  Review on the extraction of bioactive compounds and characterization of fruit industry by-products , 2022, Bioresources and Bioprocessing.

[2]  O. Darwesh,et al.  Fermentation Affects the Antioxidant Activity of Plant-Based Food Material through the Release and Production of Bioactive Components , 2021, Antioxidants.

[3]  A. Kohli,et al.  Food Processing Technologies to Develop Functional Foods With Enriched Bioactive Phenolic Compounds in Cereals , 2021, Frontiers in Plant Science.

[4]  S. Adisakwattana,et al.  Clitoria ternatea Flower Extract Attenuates Postprandial Lipemia and Increases Plasma Antioxidant Status Responses to a High-Fat Meal Challenge in Overweight and Obese Participants , 2021, Biology.

[5]  L. Bennett,et al.  Does timing of phytonutrient intake influence the suppression of postprandial oxidative stress? A systematic literature review , 2021, Redox biology.

[6]  D. Kafetzopoulos,et al.  Postprandial Bioactivity of a Spread Cheese Enriched with Mountain Tea and Orange Peel Extract in Plasma Oxidative Stress Status, Serum Lipids and Glucose Levels: An Interventional Study in Healthy Adults , 2021, Biomolecules.

[7]  Yan Zhang,et al.  Application of metabolomics for revealing the interventional effects of functional foods on metabolic diseases. , 2021, Food chemistry.

[8]  E. Chan,et al.  Natto and miso: an overview on their preparation, bioactive components and health-promoting effects , 2021, Food Research.

[9]  D. Kafetzopoulos,et al.  Olive Paste-Enriched Cookies Exert Increased Antioxidant Activities , 2021, Applied Sciences.

[10]  A. Florkiewicz,et al.  Functional Food—Consumer Motivations and Expectations , 2021, International journal of environmental research and public health.

[11]  Charis M. Galanakis,et al.  Innovations and technology disruptions in the food sector within the COVID-19 pandemic and post-lockdown era , 2021, Trends in Food Science & Technology.

[12]  M. P. Silva,et al.  The use of food by-products as a novel for functional foods: Their use as ingredients and for the encapsulation process , 2021 .

[13]  E. Levy,et al.  Efficacy of Polyphenols in the Management of Dyslipidemia: A Focus on Clinical Studies , 2021, Nutrients.

[14]  M. Kumar,et al.  Aspergillus oryzae Fermented Rice Bran: A Byproduct with Enhanced Bioactive Compounds and Antioxidant Potential , 2020, Foods.

[15]  B. Akter,et al.  Synbiotic and antioxidant activity of fruit by-products and their effect on human health , 2020 .

[16]  C. Prista,et al.  Development and physicochemical characterization of a new grass pea (Lathyrus sativus L.) miso. , 2020, Journal of the science of food and agriculture.

[17]  S. Adisakwattana,et al.  Postprandial Effect of Yogurt Enriched with Anthocyanins from Riceberry Rice on Glycemic Response and Antioxidant Capacity in Healthy Adults , 2020, Nutrients.

[18]  Xia Li,et al.  Effects of phytochemicals from plant-based functional foods on hyperlipidemia and their underpinning mechanisms , 2020 .

[19]  Kun-song Chen,et al.  Anti-diabetic effects of natural antioxidants from fruits , 2020 .

[20]  A. Rivellese,et al.  Dietary Impact on Postprandial Lipemia , 2020, Frontiers in Endocrinology.

[21]  R. Di Cagno,et al.  High-Value Compounds in Fruit, Vegetable and Cereal Byproducts: An Overview of Potential Sustainable Reuse and Exploitation , 2020, Molecules.

[22]  R. Liu,et al.  Guidelines for antioxidant assays for food components , 2020 .

[23]  A. Koutelidakis,et al.  Functional Foods and Bioactive Compounds: A Review of Its Possible Role on Weight Management and Obesity’s Metabolic Consequences , 2019, Medicines.

[24]  F. Mariotti,et al.  The Postprandial Appearance of Features of Cardiometabolic Risk: Acute Induction and Prevention by Nutrients and Other Dietary Substances , 2019, Nutrients.

[25]  G. Costabile,et al.  Effects of a diet naturally rich in polyphenols on lipid composition of postprandial lipoproteins in high cardiometabolic risk individuals: an ancillary analysis of a randomized controlled trial , 2019, European Journal of Clinical Nutrition.

[26]  Maressa Caldeira Morzelle,et al.  Is Chickpea a Potential Substitute for Soybean? Phenolic Bioactives and Potential Health Benefits , 2019, International journal of molecular sciences.

[27]  Hui He,et al.  Evaluation of hypolipidemic peptide (Val-Phe-Val-Arg-Asn) virtual screened from chickpea peptides by pharmacophore model in high-fat diet-induced obese rat , 2019, Journal of Functional Foods.

[28]  Baojun Xu,et al.  An insight into the health benefits of fermented soy products. , 2019, Food chemistry.

[29]  D. Pastore,et al.  Different effectiveness of two pastas supplemented with either lipophilic or hydrophilic/phenolic antioxidants in affecting serum as evaluated by the novel Antioxidant/Oxidant Balance approach. , 2017, Food chemistry.

[30]  F. Leighton,et al.  A Chilean Berry Concentrate Protects against Postprandial Oxidative Stress and Increases Plasma Antioxidant Activity in Healthy Humans , 2017, Oxidative medicine and cellular longevity.

[31]  Prathamesh Bharat Helkar,et al.  Review: Food Industry By-Products used as a Functional Food Ingredients , 2016 .

[32]  N. D. Pietro,et al.  Carotenoids in Cardiovascular Disease Prevention , 2016 .

[33]  Ioannis K. Kookos,et al.  Wine lees valorization: Biorefinery development including production of a generic fermentation feedstock employed for poly(3-hydroxybutyrate) synthesis , 2015 .

[34]  S. Chae,et al.  Supplementation with Aspergillus oryzae-fermented kochujang lowers serum cholesterol in subjects with hyperlipidemia. , 2015, Clinical nutrition.

[35]  F. Azizi,et al.  Functional foods-based diet as a novel dietary approach for management of type 2 diabetes and its complications: A review. , 2014, World journal of diabetes.

[36]  E. Meaney,et al.  Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. , 2014, Food & function.

[37]  B. Burton-Freeman.  Postprandial metabolic events and fruit-derived phenolics: a review of the science , 2010, British Journal of Nutrition.

[38]  E. Ainsworth,et al.  Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin–Ciocalteu reagent , 2007, Nature Protocols.

[39]  A. Mourelatos,et al.  Effect of traditional Greek Mediterranean meals on platelet aggregation in normal subjects and in patients with type 2 diabetes mellitus. , 2006, Journal of medicinal food.

[40]  P. Tamayo,et al.  Protein Content Quantification by Bradford Method , 2001 .