Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells

[1]  A. Cumano,et al.  GATA-3 promotes T-cell specification by repressing B-cell potential in pro-T cells in mice. , 2013, Blood.

[2]  Eric Vivier,et al.  Innate lymphoid cells — a proposal for uniform nomenclature , 2013, Nature Reviews Immunology.

[3]  C. Glass,et al.  Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B-cell fate , 2012, Proceedings of the National Academy of Sciences.

[4]  David Voehringer,et al.  The transcription factor GATA-3 controls cell fate and maintenance of type 2 innate lymphoid cells. , 2012, Immunity.

[5]  H. Qian,et al.  Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo , 2012, Proceedings of the National Academy of Sciences.

[6]  A. Diefenbach,et al.  Transcriptional control of innate lymphocyte fate decisions. , 2012, Current opinion in immunology.

[7]  Elin Axelsson,et al.  Essential role of EBF1 in the generation and function of distinct mature B cell types , 2012, The Journal of experimental medicine.

[8]  Ellen V Rothenberg,et al.  Transcriptional drivers of the T-cell lineage program. , 2012, Current opinion in immunology.

[9]  E. Liu,et al.  Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. , 2012, Genes & development.

[10]  J. Aster,et al.  T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling , 2011, Proceedings of the National Academy of Sciences.

[11]  G. Castellano,et al.  CCAAT/enhancer binding protein α (C/EBPα)-induced transdifferentiation of pre-B cells into macrophages involves no overt retrodifferentiation , 2011, Proceedings of the National Academy of Sciences.

[12]  M. Sigvardsson,et al.  B-lymphocyte commitment: identifying the point of no return. , 2011, Seminars in immunology.

[13]  Elinore M Mercer,et al.  Multilineage priming of enhancer repertoires precedes commitment to the B and myeloid cell lineages in hematopoietic progenitors. , 2011, Immunity.

[14]  Alejandro Chavez,et al.  A critical role for TCF-1 in T-lineage specification and differentiation , 2011, Nature.

[15]  Markus Jaritz,et al.  The transcription factor Pax5 regulates its target genes by recruiting chromatin‐modifying proteins in committed B cells , 2011, The EMBO journal.

[16]  E. Rothenberg T Cell Lineage Commitment: Identity and Renunciation , 2011, The Journal of Immunology.

[17]  R. Månsson,et al.  A dose‐dependent role for EBF1 in repressing non‐B‐cell‐specific genes , 2011, European journal of immunology.

[18]  R. Grosschedl,et al.  Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner. , 2010, Cell stem cell.

[19]  K. Garrett,et al.  Functional diversity of stem and progenitor cells with B‐lymphopoietic potential , 2010, Immunological reviews.

[20]  Rudolf Grosschedl,et al.  Early B cell factor 1 regulates B cell gene networks by activation, repression, and transcription- independent poising of chromatin. , 2010, Immunity.

[21]  Trey Ideker,et al.  A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates the B cell fate , 2010, Nature Immunology.

[22]  Rudolf Grosschedl,et al.  Transcription control of early B cell differentiation. , 2010, Current opinion in immunology.

[23]  R. Månsson,et al.  Single-cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity. , 2010, Blood.

[24]  Tsutomu Takeuchi,et al.  Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells , 2009, Nature.

[25]  Esteban Ballestar,et al.  A robust and highly efficient immune cell reprogramming system. , 2009, Cell stem cell.

[26]  D. Sahoo,et al.  Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development. , 2009, Genes & development.

[27]  Jiangwen Zhang,et al.  Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells. , 2009, Immunity.

[28]  M. Busslinger,et al.  Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis. , 2009, Immunity.

[29]  J. Hagman,et al.  Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage , 2009, Proceedings of the National Academy of Sciences.

[30]  D. Koller,et al.  The Immunological Genome Project: networks of gene expression in immune cells , 2008, Nature Immunology.

[31]  Ignacio A. Demarco,et al.  Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros , 2008, Nature Immunology.

[32]  M. Busslinger,et al.  Developmental plasticity of lymphocytes. , 2008, Current opinion in immunology.

[33]  E. Bertolino,et al.  Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5 , 2008, Nature Immunology.

[34]  R. DePinho,et al.  Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation , 2008, Nature Immunology.

[35]  M. Busslinger,et al.  Conversion of mature B cells into T cells by dedifferentiation to uncommitted progenitors , 2007, Nature.

[36]  S. Nutt,et al.  The transcriptional regulation of B cell lineage commitment. , 2007, Immunity.

[37]  M. Busslinger,et al.  Distinct Promoters Mediate the Regulation of Ebf1 Gene Expression by Interleukin-7 and Pax5 , 2006, Molecular and Cellular Biology.

[38]  M. Reth,et al.  Testing gene function early in the B cell lineage in mb1-cre mice , 2006, Proceedings of the National Academy of Sciences.

[39]  M. Busslinger,et al.  Gene repression by Pax5 in B cells is essential for blood cell homeostasis and is reversed in plasma cells. , 2006, Immunity.

[40]  J. Aster,et al.  Notch signaling controls the generation and differentiation of early T lineage progenitors , 2005, Nature Immunology.

[41]  Lina A. Thoren,et al.  Identification of Flt3+ Lympho-Myeloid Stem Cells Lacking Erythro-Megakaryocytic Potential A Revised Road Map for Adult Blood Lineage Commitment , 2005, Cell.

[42]  Harinder Singh,et al.  Assembling a gene regulatory network for specification of the B cell fate. , 2004, Developmental cell.

[43]  B. Kee,et al.  Early B Cell Factor Promotes B Lymphopoiesis with Reduced Interleukin 7 Responsiveness in the Absence of E2A , 2004, The Journal of experimental medicine.

[44]  M. Busslinger,et al.  Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene. , 2004, Genes & development.

[45]  H. Igarashi,et al.  Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. , 2002, Immunity.

[46]  M. Busslinger,et al.  Reversion of B Cell Commitment upon Loss of Pax5 Expression , 2002, Science.

[47]  Kozo Nakamura,et al.  Role of Deltex-1 as a Transcriptional Regulator Downstream of the Notch Receptor* , 2001, The Journal of Biological Chemistry.

[48]  M. Busslinger,et al.  Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors , 1999, Nature.

[49]  Ahmed Mansouri,et al.  Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2 , 1999, Nature.

[50]  Stephen L. Nutt,et al.  Commitment to the B-lymphoid lineage depends on the transcription factor Pax5 , 1999, Nature.