Interaction of nilotinib, dasatinib and bosutinib with ABCB1 and ABCG2: implications for altered anti‐cancer effects and pharmacological properties
暂无分享,去创建一个
G. Szakács | G. Kéri | L. Őrfi | Z. Takáts | Á. Apáti | B. Sarkadi | A. Váradi | K. Német | C. Özvegy‐Laczka | Mária Katona | G. Keri | C. Hegedűs | M. Magócsi | M. Katona
[1] B. Turcq,et al. Evidence that resistance to nilotinib may be due to BCR-ABL, Pgp, or Src kinase overexpression. , 2008, Cancer research.
[2] M. Pirmohamed,et al. Effective dasatinib uptake may occur without human organic cation transporter 1 (hOCT1): implications for the treatment of imatinib-resistant chronic myeloid leukemia. , 2008, Blood.
[3] T. Litman,et al. Interaction with the 5D3 Monoclonal Antibody Is Regulated by Intramolecular Rearrangements but Not by Covalent Dimer Formation of the Human ABCG2 Multidrug Transporter* , 2008, Journal of Biological Chemistry.
[4] Richard Pazdur,et al. Tasigna for Chronic and Accelerated Phase Philadelphia Chromosome–Positive Chronic Myelogenous Leukemia Resistant to or Intolerant of Imatinib , 2008, Clinical Cancer Research.
[5] J. Melo,et al. Dasatinib Cellular Uptake and Efflux in Chronic Myeloid Leukemia Cells: Therapeutic Implications , 2008, Clinical Cancer Research.
[6] Tomoko Niwa,et al. Comparison of imatinib, dasatinib, nilotinib and INNO-406 in imatinib-resistant cell lines. , 2007, Leukemia research.
[7] Balázs Sarkadi,et al. The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox). , 2008, Drug discovery today.
[8] L. Szente,et al. Membrane cholesterol selectively modulates the activity of the human ABCG2 multidrug transporter. , 2007, Biochimica et biophysica acta.
[9] Jorge Cortes,et al. Flying under the radar: the new wave of BCR–ABL inhibitors , 2007, Nature Reviews Drug Discovery.
[10] James D. Griffin,et al. Second generation inhibitors of BCR-ABL for the treatment of imatinib-resistant chronic myeloid leukaemia , 2007, Nature Reviews Cancer.
[11] M. Gasparetto,et al. Chronic myeloid leukemia stem cells possess multiple unique features of resistance to BCR-ABL targeted therapies , 2007, Leukemia.
[12] T. Holyoake,et al. Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells. , 2007, Blood.
[13] P. Manley,et al. Imatinib increases the intracellular concentration of nilotinib, which may explain the observed synergy between these drugs. , 2007, Blood.
[14] Y. Wang,et al. Imatinib mesylate and nilotinib (AMN107) exhibit high-affinity interaction with ABCG2 on primitive hematopoietic stem cells , 2007, Leukemia.
[15] D. Fabbro,et al. Beneficial effects of combining nilotinib and imatinib in preclinical models of BCR-ABL+ leukemias. , 2007, Blood.
[16] K. Német,et al. Reduction of Bcr‐Abl Function Leads to Erythroid Differentiation of K562 Cells via Downregulation of ERK , 2006, Annals of the New York Academy of Sciences.
[17] G. Szakács,et al. Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system. , 2006, Physiological reviews.
[18] T. Holyoake,et al. Functional ABCG2 is overexpressed on primary CML CD34+ cells and is inhibited by imatinib mesylate. , 2006, Blood.
[19] D. Ross,et al. Complex interaction of BCRP/ABCG2 and imatinib in BCR-ABL-expressing cells: BCRP-mediated resistance to imatinib is attenuated by imatinib-induced reduction of BCRP expression. , 2006, Blood.
[20] P. Manley,et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib. , 2006, Blood.
[21] Michael Dean,et al. Tumour stem cells and drug resistance , 2005, Nature Reviews Cancer.
[22] R. Ren,et al. Mechanisms of BCR–ABL in the pathogenesis of chronic myelogenous leukaemia , 2005, Nature Reviews Cancer.
[23] G. Kéri,et al. Multidrug transporter ABCG2 prevents tumor cell death induced by the epidermal growth factor receptor inhibitor Iressa (ZD1839, Gefitinib). , 2005, Cancer research.
[24] G. Kéri,et al. Multidrug Transporter ABCG 2 Prevents Tumor Cell Death Induced by the Epidermal Growth Factor Receptor Inhibitor Iressa ( ZD 1839 , Gefitinib ) , 2005 .
[25] Munir Pirmohamed,et al. Active transport of imatinib into and out of cells: implications for drug resistance. , 2004, Blood.
[26] Mariël Brok,et al. Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. , 2004, Blood.
[27] G. Kéri,et al. High-affinity interaction of tyrosine kinase inhibitors with the ABCG2 multidrug transporter. , 2004, Molecular pharmacology.
[28] P. Houghton,et al. Imatinib Mesylate Is a Potent Inhibitor of the ABCG2 (BCRP) Transporter and Reverses Resistance to Topotecan and SN-38 in Vitro , 2004, Cancer Research.
[29] M. Trigg. Hematopoietic stem cells. , 2004, Pediatrics.
[30] Mariël Brok,et al. Imatinib mesylate ( STI 571 ) is a substrate for the breast cancer resistance protein ( BCRP ) / ABCG 2 drug pump , 2004 .
[31] Hiroshi Watanabe,et al. Interaction of Imatinib Mesilate with Human P-Glycoprotein , 2003, Journal of Pharmacology and Experimental Therapeutics.
[32] H. Mizoguchi,et al. Anti-proliferative effect of the abl tyrosine kinase inhibitor STI571 on the P-glycoprotein positive K562/ADM cell line. , 2003, Cancer Letters.
[33] J. Melo,et al. MDR1 gene overexpression confers resistance to imatinib mesylate in leukemia cell line models. , 2003, Blood.
[34] B. Sarkadi,et al. Characterization of Drug Transport, ATP Hydrolysis, and Nucleotide Trapping by the Human ABCG2 Multidrug Transporter , 2002, The Journal of Biological Chemistry.
[35] G. Kéri,et al. Interaction of tyrosine kinase inhibitors with the human multidrug transporter proteins, MDR1 and MRP1. , 2002, Biochimica et biophysica acta.
[36] B. Torok-Storb,et al. The ABCG2 transporter is an efficient Hoechst 33342 efflux pump and is preferentially expressed by immature human hematopoietic progenitors. , 2002, Blood.
[37] M. Gottesman,et al. Multidrug resistance in cancer: role of ATP–dependent transporters , 2002, Nature Reviews Cancer.
[38] M. Dean,et al. The multidrug resistance transporter ABCG2 (breast cancer resistance protein 1) effluxes Hoechst 33342 and is overexpressed in hematopoietic stem cells. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[39] H. Nakauchi,et al. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype , 2001, Nature Medicine.
[40] B. Sarkadi,et al. Transport properties of the multidrug resistance‐associated protein (MRP) in human tumour cells , 1996, FEBS letters.
[41] G. Mickisch. Multidrug Resistance , 1996, Der Urologe A.
[42] B. Sarkadi,et al. Calcein accumulation as a fluorometric functional assay of the multidrug transporter. , 1994, Biochimica et biophysica acta.