Ursolic acid from the Chinese herb danshen (Salvia miltiorrhiza L.) upregulates eNOS and downregulates Nox4 expression in human endothelial cells.

[1]  R. Kowalski.  Studies of selected plant raw materials as alternative sources of triterpenes of oleanolic and ursolic acid types. , 2007, Journal of agricultural and food chemistry.

[2]  K. Lee,et al.  New developments in the chemistry and biology of the bioactive constituents of tanshen , 2007, Medicinal research reviews.

[3]  R. Villalobos-Molina,et al.  Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta. , 2006, Life sciences.

[4]  U. Förstermann,et al.  Reversal of endothelial nitric oxide synthase uncoupling and up-regulation of endothelial nitric oxide synthase expression lowers blood pressure in hypertensive rats. , 2006, Journal of the American College of Cardiology.

[5]  U. Förstermann,et al.  Endothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace , 2006, Circulation.

[6]  Zhong Zuo,et al.  Danshen: An Overview of Its Chemistry, Pharmacology, Pharmacokinetics, and Clinical Use , 2005, Journal of clinical pharmacology.

[7]  J. Yeung,et al.  Mechanisms of the Dilator Action of Danshen (Salvia miltiorrhiza) on Rat Isolated Femoral Artery , 2005, Journal of cardiovascular pharmacology.

[8]  H. Lehr,et al.  Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse. , 2005, Nitric oxide : biology and chemistry.

[9]  U. Förstermann,et al.  Flavonoids from Artichoke (Cynara scolymus L.) Up-Regulate Endothelial-Type Nitric-Oxide Synthase Gene Expression in Human Endothelial Cells , 2004, Journal of Pharmacology and Experimental Therapeutics.

[10]  S. Ibayashi,et al.  Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase , 2004, Circulation.

[11]  B. Tan,et al.  Comparison of cardioprotective effects using ramipril and DanShen for the treatment of acute myocardial infarction in rats. , 2003, Life sciences.

[12]  Y. Ruan,et al.  Effects of Salvia miltiorrhiza extracts on rat hypoxic pulmonary hypertension, heme oxygenase-1 and nitric oxide synthase. , 2003, Chinese medical journal.

[13]  U. Förstermann,et al.  Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. , 2003, Journal of the American College of Cardiology.

[14]  U. Förstermann,et al.  Regulation of endothelial-type NO synthase expression in pathophysiology and in response to drugs. , 2002, Nitric oxide : biology and chemistry.

[15]  U. Förstermann,et al.  Dual Effect of Ceramide on Human Endothelial Cells: Induction of Oxidative Stress and Transcriptional Upregulation of Endothelial Nitric Oxide Synthase , 2002, Circulation.

[16]  U. Förstermann,et al.  Resveratrol, a Polyphenolic Phytoalexin Present in Red Wine, Enhances Expression and Activity of Endothelial Nitric Oxide Synthase , 2002, Circulation.

[17]  U. Walter,et al.  Effects of Angiotensin II Infusion on the Expression and Function of NAD(P)H Oxidase and Components of Nitric Oxide/cGMP Signaling , 2002, Circulation research.

[18]  Y. P. Wang,et al.  Magnesium lithospermate B inhibits hypoxia-induced calcium influx and nitric oxide release in endothelial cells. , 2001, Acta pharmacologica Sinica.

[19]  Shing‐Jong Lin,et al.  Salvianolic acid B attenuates VCAM‐1 and ICAM‐1 expression in TNF‐α‐treated human aortic endothelial cells , 2001 .

[20]  Paul L Huang,et al.  Accelerated Atherosclerosis, Aortic Aneurysm Formation, and Ischemic Heart Disease in Apolipoprotein E/Endothelial Nitric Oxide Synthase Double-Knockout Mice , 2001, Circulation.

[21]  D. Baričevič,et al.  Topical anti-inflammatory activity of Salvia officinalis L. leaves: the relevance of ursolic acid. , 2001, Journal of ethnopharmacology.

[22]  T. Münzel,et al.  Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus , 2001, Circulation research.

[23]  Da-yuan Zhu,et al.  Effect of Magnesium tanshinoate B on the production of nitric oxide in endothelial cells , 2000, Molecular and Cellular Biochemistry.

[24]  Ulrich Förstermann,et al.  Structure-activity relationship of staurosporine analogs in regulating expression of endothelial nitric-oxide synthase gene. , 2000, Molecular pharmacology.

[25]  U. Förstermann,et al.  Nitric oxide in the pathogenesis of vascular disease , 2000, The Journal of pathology.

[26]  U. Förstermann,et al.  Activation of Protein Kinase Cα and/or ε Enhances Transcription of the Human Endothelial Nitric Oxide Synthase Gene , 1998 .

[27]  M. Shiao,et al.  Increase of vitamin E content in LDL and reduction of atherosclerosis in cholesterol-fed rabbits by a water-soluble antioxidant-rich fraction of Salvia miltiorrhiza. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[28]  K. Fung,et al.  Effect of sodium tanshinone IIA sulfonate in the rabbit myocardium and on human cardiomyocytes and vascular endothelial cells. , 1993, Biochemical pharmacology.

[29]  J M Roberts,et al.  The Effect of a Medicinal Chinese Herb on Platelet Function , 1982, Thrombosis and Haemostasis.

[30]  Zhe Zhou,et al.  Cryptotanshinone inhibits endothelin-1 expression and stimulates nitric oxide production in human vascular endothelial cells. , 2006, Biochimica et biophysica acta.

[31]  A. Daiber,et al.  Measurement of NAD(P)H oxidase-derived superoxide with the luminol analogue L-012. , 2004, Free radical biology & medicine.

[32]  Y. L. Chen,et al.  Salvia miltiorrhiza inhibits intimal hyperplasia and monocyte chemotactic protein‐1 expression after balloon injury in cholesterol‐fed rabbits , 2001, Journal of cellular biochemistry.

[33]  G. Chiou,et al.  Studies on cardiovascular actions of Salvia miltiorrhiza. , 1986, The American journal of Chinese medicine.