Preclinical electrogastrography in experimental pigs

Preclinical electrogastrography in experimental pigs Surface electrogastrography (EGG) is a non-invasive means of recording gastric myoelectric activity or slow waves from cutaneous leads placed over the stomach. This paper provides a comprehensive review of preclinical EGG. Our group recently set up and worked out the methods for EGG in experimental pigs. We gained our initial experience in the use of EGG in assessment of porcine gastric myoelectric activity after volume challenge and after intragastric administration of itopride and erythromycin. The mean dominant frequency in pigs is comparable with that found in humans. EGG in experimental pigs is feasible. Experimental EGG is an important basis for further preclinical projects in pharmacology and toxicology.

[1]  R. Koerner,et al.  The use of erythromycin as a gastrointestinal prokinetic agent in adult critical care: benefits versus risks. , 2007, The Journal of antimicrobial chemotherapy.

[2]  M. Nobilis,et al.  Experimental Goettingen minipig and beagle dog as two species used in bioequivalence studies for clinical pharmacology (5-aminosalicylic acid and atenolol as model drugs). , 1999, General physiology and biophysics.

[3]  J. Kvetina,et al.  The use of wireless capsule enteroscopy in a preclinical study: a novel diagnostic tool for indomethacin-induced gastrointestinal injury in experimental pigs. , 2008, Neuro endocrinology letters.

[4]  J. Kvetina,et al.  Different solutions used for submucosal injection influenced early healing of gastric endoscopic mucosal resection in a preclinical study in experimental pigs , 2008, Surgical Endoscopy.

[5]  M P Mintchev,et al.  Accuracy of cutaneous recordings of gastric electrical activity. , 1993, Gastroenterology.

[6]  Z. Lin,et al.  Autonomic nervous system response to a solid meal and water loading in healthy children: its relation to gastric myoelectrical activity , 2007, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[7]  M. Stringer,et al.  Erythromycin as a prokinetic agent in infants and children , 2001 .

[8]  E. Chihara,et al.  Effect of the preliminary hydration on gastric emptying time for water in healthy volunteers , 2009, Acta anaesthesiologica Scandinavica.

[9]  Kazuyuki Suzuki,et al.  Effect of a muscarinic M3 receptor agonist on gastric motility , 2007, Journal of gastroenterology and hepatology.

[10]  M. Stringer,et al.  Review article: erythromycin as a prokinetic agent in infants and children. , 2001, Alimentary pharmacology & therapeutics.

[11]  G. Riezzo,et al.  Effects of probiotic and prebiotic on gastrointestinal motility in newborns. , 2009, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[12]  J. Miranda,et al.  Electrical and mechanical effects of hyoscine butylbromide on the human stomach: a non-invasive approach , 2009, Physiological measurement.

[13]  G. Lindberg,et al.  24-hour ambulatory electrogastrography in healthy volunteers. , 1996, Scandinavian journal of gastroenterology.

[14]  A. Diamanti,et al.  Gastric Electric Activity Assessed by Electrogastrography and Gastric Emptying Scintigraphy in Adolescents With Eating Disorders , 2003, Journal of pediatric gastroenterology and nutrition.

[15]  Y. Chao,et al.  Effects of music on gastric myoelectrical activity in healthy humans , 2007, International journal of clinical practice.

[16]  Pankaj J Pasricha,et al.  Correlations Among Electrogastrogram, Gastric Dysmotility, and Duodenal Dysmotility in Patients With Functional Dyspepsia , 2009, Journal of clinical gastroenterology.

[17]  Richard W. McCallum,et al.  Electrogastrography: Principles and Applications , 1994 .

[18]  Michael P. Jones,et al.  Oral Erythromycin and Symptomatic Relief of Gastroparesis: A Systematic Review , 2003, American Journal of Gastroenterology.

[19]  M. Mintchev,et al.  Electrogastrography: a noninvasive technique to evaluate gastric electrical activity. , 1998, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

[20]  M. Sandin,et al.  Effects of fentanyl on gastric myoelectrical activity: a possible association with polymorphisms of the μ‐opioid receptor gene? , 2008, Acta anaesthesiologica Scandinavica.

[21]  F. Chang,et al.  Electrogastrography: Basic knowledge, recording, processing and its clinical applications , 2005, Journal of gastroenterology and hepatology.

[22]  C. Yi,et al.  Clinical utility of electrogastrography and the water load test in patients with upper gastrointestinal symptoms. , 2006, Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.

[23]  Michael Camilleri,et al.  Measurement of gastrointestinal motility in the GI laboratory. , 1998, Gastroenterology.

[24]  Zbyněk Svoboda,et al.  Wireless Video Capsule Enteroscopy in Preclinical Studies: Methodical Design of Its Applicability in Experimental Pigs , 2009, Digestive Diseases and Sciences.

[25]  Michael P. Jones,et al.  The water load test: observations from healthy controls and patients with functional dyspepsia. , 2003, American journal of physiology. Gastrointestinal and liver physiology.

[26]  H. Parkman,et al.  Electrogastrography: a document prepared by the gastric section of the American Motility Society Clinical GI Motility Testing Task Force , 2003, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[27]  S. Ba.  The effects of general anaesthesia on antroduodenal motility, gastric pH and gastric emptying in man. , 1991 .

[28]  B. Schirmer,et al.  Postprandial Response of Gastric Slow Waves: Correlation of Serosal Recordings with the Electrogastrogram , 2000, Digestive Diseases and Sciences.

[29]  K. Koch,et al.  Reproducibility of Gastric Myoelectrical Activity and the Water Load Test in Patients with Dysmotility-like Dyspepsia Symptoms and in Control Subjects , 2000, Journal of clinical gastroenterology.

[30]  A. Keshavarzian,et al.  Erythromycin accelerates gastric emptying of indigestible solids and transpyloric migration of the tip of an enteral feeding tube in fasting and fed states. , 1993, The American journal of gastroenterology.

[31]  S. Rejchrt,et al.  Correlation of electrogastrography and gastric emptying rate estimated by , 2007 .

[32]  T. Kararli.  Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals , 1995, Biopharmaceutics & drug disposition.

[33]  J. Kvetina,et al.  Minipig as a model for drug metabolism in man: comparison of in vitro and in vivo metabolism of propafenone. , 2003, Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.

[34]  Jan Österreicher,et al.  Wireless Capsule Endoscopy in Enteropathy Induced by Nonsteroidal Anti-inflammatory Drugs in Pigs , 2010, Digestive Diseases and Sciences.

[35]  W. Orr,et al.  Effects of meal volume and composition on gastric myoelectrical activity. , 1998, American journal of physiology. Gastrointestinal and liver physiology.

[36]  M. Bortolotti.  ELECTROGASTROGRAPHY: A SEDUCTIVE PROMISE, ONLY PARTIALLY KEPT , 1998, American Journal of Gastroenterology.

[37]  M. Nobilis,et al.  Comparative biotransformation and disposition studies of nabumetone in humans and minipigs using high-performance liquid chromatography with ultraviolet, fluorescence and mass spectrometric detection. , 2003, Journal of pharmaceutical and biomedical analysis.

[38]  T. Saito,et al.  Gastroprokinetic effect of a new benzamide derivative itopride and its action mechanisms in conscious dogs. , 1996, Japanese journal of pharmacology.

[39]  M. Camilleri,et al.  Gastric axial forces in experimentally delayed and accelerated gastric emptying. , 1993, The American journal of physiology.

[40]  B. Klapp,et al.  Electrogastrography as a diagnostic tool for delayed gastric emptying in functional dyspepsia and irritable bowel syndrome , 2003, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[41]  R. Brand,et al.  Effects of low doses of erythromycin on the 13C Spirulina platensis gastric emptying breath test and electrogastrogram: a controlled study in healthy volunteers. , 2001 .

[42]  C. Malbert,et al.  Gastric but not duodenal motor effects of oral erythromycin are dose related , 1995, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

[43]  A. Ogawa,et al.  Electrogastrography abnormality in eating disorders , 2004, Psychiatry and clinical neurosciences.

[44]  J. Galmiche,et al.  Erythromycin enhances fasting and postprandial proximal gastric tone in humans. , 1995, Gastroenterology.

[45]  S. Bor,et al.  The acute effect of oral ethanol intake on gastric myoelectrical activity in healthy volunteers. , 2007, The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.

[46]  C. Faure,et al.  Effect of Meal and Intravenous Erythromycin on Manometric and Electrogastrographic Measurements of Gastric Motor and Electrical Activity , 2000, Digestive Diseases and Sciences.