Current trends in thrombolysis: implications for diagnostic and interventional radiology.

Current trends in thrombolysis are of relevance to both diagnostic and interventional radiologists. In addition to the traditional use of thrombolytic therapy in conditions such as peripheral arterial thrombosis, venous thrombosis and pulmonary embolic disease, more recent interest has focused on the potential use of thrombolysis in acute stroke. There will be significant implications for the provision of radiological services if current trials show a favourable outcome for thrombolysis in stroke. This article looks at a range of conditions in which thrombolysis may be useful, on the strength of currently available evidence. Future trends will depend on the outcomes of the current trials.

[1]  J. Alpert,et al.  Thrombolytic therapy for pulmonary embolism: is it effective? Is it safe? When is it indicated? , 1997, Archives of internal medicine.

[2]  Werner Hacke,et al.  Imaging-Based Decision Making in Thrombolytic Therapy for Ischemic Stroke: Present Status , 2003, Stroke.

[3]  G. Rudofsky,et al.  Retrospective Analysis of Rt-pa Thrombolysis Combined with PGE1 in Patients with Peripheral Arterial Occlusions , 2000, Angiology.

[4]  R. Galland,et al.  Prospective randomized trial of high‐dose bolus versus low‐dose tissue plasminogen activator infusion in the management of acute limb ischaemia , 1997 .

[5]  olfgang,et al.  HEPARIN PLUS ALTEPLASE COMPARED WITH HEPARIN ALONE IN PATIENTS WITH SUBMASSIVE PULMONARY EMBOLISM , 2002 .

[6]  G. Lenzi,et al.  Clinical and instrumental evaluation of patients with ischemic stroke within the first six hours , 1989, Journal of the Neurological Sciences.

[7]  S. Kahn,et al.  The post-thrombotic syndrome: current knowledge, controversies, and directions for future research. , 2002, Blood reviews.

[8]  H. Yoon,et al.  Using a peptide inhibitor of the glycoprotein IIb/IIIa platelet receptor: initial experience in patients with acute peripheral arterial occlusions. , 2002, AJR. American journal of roentgenology.

[9]  C. Jerjes-Sánchez,et al.  Streptokinase and heparin versus heparin alone in massive pulmonary embolism: A randomized controlled trial , 2005, Journal of Thrombosis and Thrombolysis.

[10]  M. Meissner.  Thrombolytic therapy for acute deep vein thrombosis and the venous registry. , 2002, Reviews in cardiovascular medicine.

[11]  F. Van de Werf,et al.  Pharmacologic Reperfusion Therapy for Acute Myocardial Infarction , 2002, Journal of Thrombosis and Thrombolysis.

[12]  B. Lindblad,et al.  Incidence of venous thromboembolism verified by necropsy over 30 years. , 1991, BMJ.

[13]  R. Günther,et al.  Percutaneous treatment of thrombosed primary arteriovenous hemodialysis access fistulae. , 2000, Kidney international.

[14]  A. Chait,et al.  An Alternative Approach: Antegrade Catheter-directed Thrombolysis in a Case of Phlegmasia Cerulea Dolens , 1999, The American surgeon.

[15]  D. Bergqvist,et al.  Cost of Long-Term Complications of Deep Venous Thrombosis of the Lower Extremities: An Analysis of a Defined Patient Population in Sweden , 1997, Annals of Internal Medicine.

[16]  J. Wardlaw,et al.  Therapeutic thrombolysis for acute ischaemic stroke , 2003, BMJ : British Medical Journal.

[17]  M. Kaste,et al.  The European Cooperative Acute Stroke Study (ECASS) , 1993 .

[18]  T. Buckenham,et al.  Peripheral thrombolysis for acute‐onset claudication , 1999, The British journal of surgery.

[19]  B. Hopkinson,et al.  Randomized trial of intra‐arterial recombinant tissue plasminogen activator, intravenous recombinant tissue plasminogen activator and intra‐arterial streptokinase in peripheral arterial thrombolysis , 1991, The British journal of surgery.

[20]  Douglas S. Lee,et al.  A metaanalysis comparing surgical thrombectomy, mechanical thrombectomy, and pharmacomechanical thrombolysis for thrombosed dialysis grafts. , 2002, Journal of vascular surgery.

[21]  A. Forster,et al.  Thrombolysis in Deep Vein Thrombosis: Is there still an Indication? , 2001, Thrombosis and Haemostasis.

[22]  T. Walley,et al.  Superiority and equivalence in thrombolytic drugs: an interpretation. , 2003, QJM : monthly journal of the Association of Physicians.

[23]  K. Ouriel,et al.  Thrombolysis or peripheral arterial surgery: phase I results. TOPAS Investigators. , 1996, Journal of vascular surgery.

[24]  R. Califf,et al.  Combined accelerated tissue-plasminogen activator and platelet glycoprotein IIb/IIIa integrin receptor blockade with Integrilin in acute myocardial infarction. Results of a randomized, placebo-controlled, dose-ranging trial. IMPACT-AMI Investigators. , 1997, Circulation.

[25]  G. Needham.  Making the best use of a department of clinical radiology--guidelines for doctors. , 1996, Health bulletin.

[26]  J. Buring,et al.  Pooled analyses of randomized trials of streptokinase and heparin in phlebographically documented acute deep venous thrombosis. , 1984, The American journal of medicine.

[27]  P. Sandercock,et al.  What Is the Best Imaging Strategy for Acute Stroke , 2004 .

[28]  W. Kirch,et al.  Short- and Long-Term Results of Abciximab Versus Aspirin in Conjunction with Thrombolysis for Patients with Peripheral Occlusive Arterial Disease and Arterial Thrombosis , 2000, Angiology.

[29]  A. Comerota.  Quality-of-life improvement using thrombolytic therapy for iliofemoral deep venous thrombosis. , 2002, Reviews in cardiovascular medicine.

[30]  Joseph P. Broderick,et al.  Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. , 1995 .

[31]  H. Büller,et al.  Use of a clinical decision rule in combination with D-dimer concentration in diagnostic workup of patients with suspected pulmonary embolism: a prospective management study. , 2002, Archives of internal medicine.

[32]  R. Rhodes,et al.  RESULTS OF A PROSPECTIVE RANDOMIZED TRIAL EVALUATING SURGERY VERSUS THROMBOLYSIS FOR ISCHEMIA OF THE LOWER EXTREMITY. DISCUSSION , 1994 .

[33]  K. Ouriel,et al.  A comparison of recombinant urokinase with vascular surgery as initial treatment for acute arterial occlusion of the legs. Thrombolysis or Peripheral Arterial Surgery (TOPAS) Investigators. , 1998, The New England journal of medicine.

[34]  J. Polak,et al.  Intraarterial thrombolysis of lower extremity occlusions: prospective, randomized comparison of forced periodic infusion and conventional slow continuous infusion. , 1993, Radiology.

[35]  A. Gottsäter,et al.  Clinically suspected pulmonary embolism: is it safe to withhold anticoagulation after a negative spiral CT? , 2001, European Radiology.

[36]  M. Kaste,et al.  Thrombolytic therapy for acute ischaemic stroke , 1997, The Lancet.

[37]  T. Walley,et al.  Comparative efficacy of thrombolytics in acute myocardial infarction: a systematic review. , 2003, QJM : monthly journal of the Association of Physicians.

[38]  E. Braunwald,et al.  Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion , 1993, The Lancet.

[39]  M. Kaste,et al.  Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS) , 1995, JAMA.

[40]  S. Ellis,et al.  Tissue-plasminogen activator for acute ischaemic stroke , 1997, The Lancet.

[41]  K. Mcintyre,et al.  Long-term benefit of thrombolytic therapy in patients with pulmonary embolism , 2000, Vascular medicine.

[42]  M. Elsharawy,et al.  Early results of thrombolysis vs anticoagulation in iliofemoral venous thrombosis. A randomised clinical trial. , 2002, European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery.

[43]  A. Skene,et al.  Survival Outcomes 1 Year After Reperfusion Therapy With Either Alteplase or Reteplase for Acute Myocardial Infarction: Results From the Global Utilization of Streptokinase and t-PA for Occluded Coronary Arteries (GUSTO) III Trial , 2000, Circulation.

[44]  P Wainwright,et al.  Virtual outreach: a randomised controlled trial and economic evaluation of joint teleconferenced medical consultations. , 2004, Health technology assessment.

[45]  A. Høiseth,et al.  Streptokinase of heparin in the treatment of deep vein thrombosis. Follow-up results of a prospective study. , 2009, Acta medica Scandinavica.

[46]  Samuel Z Goldhaber,et al.  Acute pulmonary embolism: clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER) , 1999, The Lancet.

[47]  R. Ahmadi,et al.  Treatment of subclavian-axillary vein thrombosis: long-term outcome of anticoagulation versus systemic thrombolysis. , 2002, Thrombosis research.

[48]  R. Green,et al.  A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia. , 1994, Journal of vascular surgery.

[49]  K. Berbaum,et al.  Two urokinase dose regimens in native arterial and graft occlusions: initial results of a prospective, randomized clinical trial. , 1991, Radiology.

[50]  W. Kirch,et al.  Use of Abciximab and Tirofiban in Patients with Peripheral Arterial Occlusive Disease and Arterial Thrombosis , 2003, Angiology.

[51]  P. Pereira,et al.  Peripheral artery occlusion: treatment with abciximab plus urokinase versus with urokinase alone--a randomized pilot trial (the PROMPT Study). Platelet Receptor Antibodies in Order to Manage Peripheral Artery Thrombosis. , 2001, Radiology.

[52]  Deepak L. Bhatt,et al.  Triple antiplatelet therapy during percutaneous coronary intervention is associated withimproved outcomes including one-year survival , 2003 .

[53]  J. Earnshaw,et al.  National Audit of Thrombolysis for Acute Leg Ischemia (NATALI): clinical factors associated with early outcome. , 2004, Journal of vascular surgery.

[54]  A. Brady,et al.  Thrombolytic therapy for acute ischaemic stroke , 2003 .

[55]  G. Gardiner,et al.  Acceleration of thrombolysis with a high-dose transthrombus bolus technique. , 1989, Radiology.

[56]  D. Kessel,et al.  Infusion techniques for peripheral arterial thrombolysis. , 2004, The Cochrane database of systematic reviews.

[57]  A. Forster,et al.  Tissue plasminogen activator for the treatment of deep venous thrombosis of the lower extremity: a systematic review. , 2001, Chest.

[58]  P. Myllynen,et al.  A RANDOMISED CLINICAL TRIAL , 1989 .