MRI-based high-dimensional hippocampal mapping in mesial temporal lobe epilepsy.

MRI-based evaluation of the hippocampus is important in the assessment and treatment of patients with mesial temporal lobe epilepsy (MTLE). Using MRI-based large-deformation high-dimensional mapping (HDM-LD), which allows structural evaluation of regions of the hippocampus, we document the HDM-LD-defined pattern of hippocampal deformation in MTLE patients compared with matched controls. In 30 subjects with MTLE and confirmed medial temporal lobe sclerosis (MTS), we performed measurements of intracranial area, brain parenchymal volume and deformation-based hippocampal segmentations, and then grouped patients into right and left MTS groups (resulting in 15 subjects in each group). Using HDM-LD techniques, we compared the right and left MTS groups with a group of 15 matched controls. Analysis included both the MTS and contralateral hippocampi, and covariance for changes in brain parenchymal volume. Final results were interpreted using a segmentation showing normal hippocampal surface subfield anatomy. Comparing the MTS groups with controls, after covarying with brain parenchymal volume, the MTS hippocampi showed significant volume loss (P < 0.0001), contralateral hippocampi showed no significant volume loss. HDM-LD techniques showed significant shape changes, with marked inward deviation in the Sommer sector of the MTS hippocampi. In the contralateral hippocampi, the inferior surface of the hippocampal body showed inward deformation in the medial aspect of the subiculum, with minimal involvement of the Sommer sector. HDM-LD shows involvement of subregions of the hippocampus which are consistent with MTS histopathology. Contralateral hippocampi show different HDM-LD changes, suggesting that the underlying disease process in the contralateral hippocampi is different from MTS.

[1]  M I Miller,et al.  Mathematical textbook of deformable neuroanatomies. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[2]  Sarang Joshi,et al.  Hippocampal Deformation‐based Shape Analysis in Epilepsy and Unilateral Mesial Temporal Sclerosis , 2003, Epilepsia.

[3]  M. Cook,et al.  Accuracy of coregistration of single-photon emission CT with MR via a brain surface matching technique. , 1996, AJNR. American journal of neuroradiology.

[4]  M. Miller,et al.  Statistical Analysis of Hippocampal Asymmetry in Schizophrenia , 2001, NeuroImage.

[5]  Michael I. Miller,et al.  Hierarchical brain mapping via a generalized Dirichlet solution for mapping brain manifolds , 1995, Optics & Photonics.

[6]  C R Jack,et al.  Bilaterally symmetric hippocampi and surgical outcome , 1995, Neurology.

[7]  Henri M. Duvernoy.  The human hippocampus , 1988 .

[8]  C R Jack,et al.  MRI-based hippocampal volumetrics: data acquisition, normal ranges, and optimal protocol. , 1995, Magnetic resonance imaging.

[9]  M. Miller,et al.  High-dimensional mapping of the hippocampus in depression. , 2003, The American journal of psychiatry.

[10]  W T Blume,et al.  A randomized, controlled trial of surgery for temporal-lobe epilepsy. , 2001, The New England journal of medicine.

[11]  G McCarthy,et al.  Bilateral Hippocampal Atrophy in Medial Temporal Lobe Epilepsy , 1995, Epilepsia.

[12]  P. Davies,et al.  Dementia of the Alzheimer type. , 1980, Annual review of neuroscience.

[13]  H. Duvernoy,et al.  The Human Hippocampus: Functional Anatomy, Vascularization and Serial Sections with MRI , 1997 .

[14]  Daniel H. Mathalon,et al.  Age-related decline in MRI volumes of temporal lobe gray matter but not hippocampus , 1995, Neurobiology of Aging.

[15]  Michael I. Miller,et al.  On The Geometry and Shape of Brain Sub-Manifolds , 1997, Int. J. Pattern Recognit. Artif. Intell..

[16]  Bratz.  Ammonshornbefunde bei Epileptischen , 2005, Archiv für Psychiatrie und Nervenkrankheiten.

[17]  W. A. Hanson,et al.  Interactive 3D segmentation of MRI and CT volumes using morphological operations. , 1992, Journal of computer assisted tomography.

[18]  G. Ojemann,et al.  Outcome following surgery in patients with bitemporal interictal epileptiform patterns , 1997, Neurology.

[19]  S. Joshi,et al.  Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus , 2000, Neurology.

[20]  E. Bertram,et al.  Volumetric Magnetic Resonance Imaging Evidence of Bilateral Hippocampal Atrophy in Mesial Temporal Lobe Epilepsy , 1997, Epilepsia.

[21]  Michael I. Miller,et al.  A deformable neuroanatomy textbook based on viscous uid mechanics , 1993 .

[22]  L. Martinian,et al.  Cytoarchitectural Abnormalities in Hippocampal Sclerosis , 2002, Journal of neuropathology and experimental neurology.

[23]  M. Jones-Gotman,et al.  Volumetric Magnetic Resonance Imaging , 1994 .

[24]  M Ashtari,et al.  Bilateral reductions in hippocampal volume in adults with epilepsy and a history of febrile seizures , 1997, Journal of neurology, neurosurgery, and psychiatry.

[25]  D R Fish,et al.  Methods for normalization of hippocampal volumes measured with MR. , 1995, AJNR. American journal of neuroradiology.

[26]  A Olivier,et al.  Mesial atrophy and outcome after amygdalohippocampectomy or temporal lobe removal , 1996, Annals of neurology.

[27]  G. Jackson,et al.  Hemicranial Volume Deficits in Patients with Temporal Lobe Epilepsy With and Without Hippocampal Sclerosis , 1998, Epilepsia.

[28]  Ari Syngeniotis,et al.  Seizure‐associated hippocampal volume loss: A longitudinal magnetic resonance study of temporal lobe epilepsy , 2002, Annals of neurology.

[29]  C. Jack,et al.  Rate of medial temporal lobe atrophy in typical aging and Alzheimer's disease , 1998, Neurology.

[30]  P H Crandall,et al.  Ictal localization of temporal lobe seizures with scalp/sphenoidal recordings , 1989, Neurology.

[31]  W. J. Brown,et al.  Temporal Lobe Volumetric Cell Densities in Temporal Lobe Epilepsy , 1984, Epilepsia.

[32]  Clinical evaluation and noninvasive electroencephalography. Preoperative evaluation. , 1995, Neuroimaging clinics of North America.

[33]  G. Cascino,et al.  Clinical correlations with hippocampal atrophy. , 1995, Magnetic resonance imaging.

[34]  Alexander Hammers,et al.  Progressive neocortical damage in epilepsy , 2003, Annals of neurology.

[35]  Gregory McCarthy,et al.  Quantitative magnetic resonance imaging in temporal lobe epilepsy: Relationship to neuropathology and neuropsychological function , 1992, Annals of neurology.

[36]  K O Lim,et al.  Cortical and Hippocampal Volume Deficits in Temporal Lobe Epilepsy , 1997, Epilepsia.

[37]  U. Grenander,et al.  Hippocampal morphometry in schizophrenia by high dimensional brain mapping. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[38]  G. Jackson,et al.  Hippocampal Sclerosis in the MR Era , 2002 .

[39]  C R Jack,et al.  Volumetric magnetic resonance imaging. Clinical applications and contributions to the understanding of temporal lobe epilepsy. , 1997, Archives of neurology.

[40]  C R Jack,et al.  Magnetic resonance image–based hippocampal volumentry: Correlation with outcome after temporal lobectomy , 1992, Annals of neurology.

[41]  Roberto Scopigno,et al.  Using Marching Cubes on Small Machines , 1994, CVGIP Graph. Model. Image Process..

[42]  R. Kuzniecky,et al.  Hippocampal sclerosis without detectable hippocampal atrophy , 1994, Neurology.

[43]  Jae Hyoung Kim,et al.  Fast spin-echo MR in hippocampal sclerosis: correlation with pathology and surgery. , 1995, AJNR. American journal of neuroradiology.

[44]  Rebecca S. N. Liu,et al.  The structural consequences of newly diagnosed seizures , 2002, Annals of neurology.

[45]  S. Joshi,et al.  Mesial temporal sclerosis and temporal lobe epilepsy: MR imaging deformation-based segmentation of the hippocampus in five patients. , 2000, Radiology.