No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice

[1]  C. Instanes,et al.  Gamma radiation at a human relevant low dose rate is genotoxic in mice , 2016, Scientific Reports.

[2]  Kent D. Sugden,et al.  Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA* , 2016, The Journal of Biological Chemistry.

[3]  S. Toyokuni,et al.  Malignant mesothelioma as an oxidative stress-induced cancer: An update. , 2015, Free radical biology & medicine.

[4]  A. Chakraborty,et al.  Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation* ♦ , 2015, The Journal of Biological Chemistry.

[5]  C. Burrows,et al.  A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These “Spare Tires” Have an Evolved Function? , 2015, ACS central science.

[6]  T. Massey,et al.  Effect of 8-oxoguanine glycosylase deficiency on aflatoxin B1 tumourigenicity in mice. , 2015, Mutagenesis.

[7]  C. Burrows,et al.  The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures , 2015, Nucleic acids research.

[8]  C. Instanes,et al.  Genotoxic effects of two-generational selenium deficiency in mouse somatic and testicular cells. , 2015, Mutagenesis.

[9]  Shiladitya Sengupta,et al.  New paradigms in the repair of oxidative damage in human genome: mechanisms ensuring repair of mutagenic base lesions during replication and involvement of accessory proteins , 2015, Cellular and Molecular Life Sciences.

[10]  M. Lei,et al.  Defective Repair of Uracil Causes Telomere Defects in Mouse Hematopoietic Cells* , 2015, The Journal of Biological Chemistry.

[11]  M. Dizdaroglu.  Oxidatively induced DNA damage and its repair in cancer. , 2015, Mutation research. Reviews in mutation research.

[12]  C. Instanes,et al.  Single cell gel electrophoresis (SCGE) and Pig-a mutation assay in vivo-tools for genotoxicity testing from a regulatory perspective: a study of benzo[a]pyrene in Ogg1(-/-) mice. , 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

[13]  Sukaina Rashid,et al.  DNA Mismatch Repair and Oxidative DNA Damage: Implications for Cancer Biology and Treatment , 2014, Cancers.

[14]  D. Reichmann,et al.  About the dangers, costs and benefits of living an aerobic lifestyle. , 2014, Biochemical Society transactions.

[15]  V. Bohr,et al.  Cockayne Syndrome group B protein stimulates NEIL2 DNA glycosylase activity , 2014, Mechanisms of Ageing and Development.

[16]  B. Dalhus,et al.  Human NEIL3 is mainly a monofunctional DNA glycosylase removing spiroimindiohydantoin and guanidinohydantoin. , 2013, DNA repair.

[17]  S. Wallace.  DNA glycosylases search for and remove oxidized DNA bases , 2013, Environmental and molecular mutagenesis.

[18]  Mahmood Khan,et al.  Emerging role of oxidative stress in metabolic syndrome and cardiovascular diseases: important role of Rac/NADPH oxidase , 2013, The Journal of pathology.

[19]  A. Tomkinson,et al.  Prereplicative repair of oxidized bases in the human genome is mediated by NEIL1 DNA glycosylase together with replication proteins , 2013, Proceedings of the National Academy of Sciences.

[20]  N. O’Callaghan,et al.  Defective Repair of Oxidative Base Lesions by the DNA Glycosylase Nth1 Associates with Multiple Telomere Defects , 2013, PLoS genetics.

[21]  J. Shaddock,et al.  Sensitivity of the Pig-a assay for detecting gene mutation in rats exposed acutely to strong clastogens. , 2013, Mutagenesis.

[22]  H. van Steeg,et al.  Oxidative DNA damage and nucleotide excision repair. , 2013, Antioxidants & redox signaling.

[23]  M. Bjørås,et al.  Base excision repair. , 2013, Cold Spring Harbor perspectives in biology.

[24]  M. Evans,et al.  Markers of oxidant stress that are clinically relevant in aging and age-related disease , 2013, Mechanisms of Ageing and Development.

[25]  H. Sampath,et al.  8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction , 2012, PloS one.

[26]  M. Bjørås,et al.  Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells. , 2012, Cell reports.

[27]  S. Tannenbaum,et al.  Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer , 2012, Proceedings of the National Academy of Sciences.

[28]  M. Neuberger,et al.  Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung−/−Msh2−/− mice , 2012, Nucleic acids research.

[29]  J. Kong,et al.  Oxidative stress in neurodegenerative diseases , 2012, Neural regeneration research.

[30]  R. S. Sohal,et al.  The redox stress hypothesis of aging. , 2012, Free radical biology & medicine.

[31]  M. Dizdaroglu,et al.  Mechanisms of free radical-induced damage to DNA , 2012, Free radical research.

[32]  U. Brandt,et al.  Molecular mechanisms of superoxide production by the mitochondrial respiratory chain. , 2012, Advances in experimental medicine and biology.

[33]  M. Bjørås,et al.  Endonuclease VIII-like 3 (Neil3) DNA glycosylase promotes neurogenesis induced by hypoxia-ischemia , 2011, Proceedings of the National Academy of Sciences.

[34]  S. Dertinger,et al.  When pigs fly: immunomagnetic separation facilitates rapid determination of Pig-a mutant frequency by flow cytometric analysis. , 2011, Mutation research.

[35]  H. Sampath,et al.  Variable penetrance of metabolic phenotypes and development of high-fat diet-induced adiposity in NEIL1-deficient mice. , 2011, American journal of physiology. Endocrinology and metabolism.

[36]  M. Valko,et al.  Arsenic: toxicity, oxidative stress and human disease , 2011, Journal of applied toxicology : JAT.

[37]  A. Bird,et al.  Embryonic lethal phenotype reveals a function of TDG in maintaining epigenetic stability , 2011, Nature.

[38]  M. Fenech,et al.  A quantitative PCR method for measuring absolute telomere length , 2011, Biological Procedures Online.

[39]  S. Dertinger,et al.  The in vivo pig‐a gene mutation assay, a potential tool for regulatory safety assessment , 2010, Environmental and molecular mutagenesis.

[40]  R. Hamanaka,et al.  Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. , 2010, Trends in biochemical sciences.

[41]  C. Theriot,et al.  RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures. , 2010, DNA repair.

[42]  David B. Rhee,et al.  Characterization of Oxidative Guanine Damage and Repair in Mammalian Telomeres , 2010, PLoS genetics.

[43]  Xiaobei Zhao,et al.  The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo , 2010, Proceedings of the National Academy of Sciences.

[44]  R. Lloyd,et al.  Targeted deletion of the genes encoding NTH1 and NEIL1 DNA N-glycosylases reveals the existence of novel carcinogenic oxidative damage to DNA. , 2009, DNA repair.

[45]  Stanley T. Omaye,et al.  Air pollutants, oxidative stress and human health. , 2009, Mutation research.

[46]  J. Bemis,et al.  Erythrocyte-based Pig-a gene mutation assay: demonstration of cross-species potential. , 2008, Mutation research.

[47]  H. Maki,et al.  MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis. , 2007, Cancer research.

[48]  S. Das,et al.  Alcohol-induced oxidative stress. , 2007, Life sciences.

[49]  A. Órfão,et al.  Quantitative analysis of the expression of glycosylphosphatidylinositol‐anchored proteins during the maturation of different hematopoietic cell compartments of normal bone marrow , 2007, Cytometry. Part B, Clinical cytometry.

[50]  K. Shinozuka,et al.  Major oxidative products of cytosine are substrates for the nucleotide incision repair pathway. , 2007, DNA repair.

[51]  E. Seeberg,et al.  Repair and mutagenesis at oxidized DNA lesions in the developing brain of wild-type and Ogg1−/− mice , 2006, Oncogene.

[52]  M. Valko,et al.  Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.

[53]  C. Corless,et al.  The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[54]  E. Friedberg,et al.  Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage Version 7. , 2004, DNA repair.

[55]  Y. Nakabeppu,et al.  Hematopoietic tissue-specific expression of mouse Neil3 for endonuclease VIII-like protein. , 2005, Journal of biochemistry.

[56]  Kent D. Sugden,et al.  Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoin. , 2005, Chemical research in toxicology.

[57]  M. Davies,et al.  The oxidative environment and protein damage. , 2005, Biochimica et biophysica acta.

[58]  Kent D. Sugden,et al.  Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2. , 2005, DNA repair.

[59]  W. Stehbens.  Oxidative stress in viral hepatitis and AIDS. , 2004, Experimental and molecular pathology.

[60]  D. Barnes,et al.  Deficiencies in mouse Myh and Ogg1 result in tumor predisposition and G to T mutations in codon 12 of the K-ras oncogene in lung tumors. , 2004, Cancer research.

[61]  J. Lambeth.  NOX enzymes and the biology of reactive oxygen , 2004, Nature Reviews Immunology.

[62]  Asako Isogawa.  Functional cooperation of Ogg1 and Mutyh in preventing G: C-->T: a transversions in mice. , 2004, Fukuoka igaku zasshi = Hukuoka acta medica.

[63]  E. Friedberg,et al.  Database of mouse strains carrying targeted mutations in genes affecting biological responses to DNA damage. Version 5. , 2006, DNA repair.

[64]  K. Sakumi,et al.  Mutator Phenotype of MUTYH-null Mouse Embryonic Stem Cells* , 2003, Journal of Biological Chemistry.

[65]  J. Parsons,et al.  Compromised Incision of Oxidized Pyrimidines in Liver Mitochondria of Mice Deficient in NTH1 and OGG1 Glycosylases* , 2003, Journal of Biological Chemistry.

[66]  K. Uchida,et al.  4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. , 2003, Progress in lipid research.

[67]  T. Tsuzuki,et al.  Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption. , 2003, Cancer research.

[68]  C. Burrows,et al.  In vitro nucleotide misinsertion opposite the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin and DNA synthesis past the lesions using Escherichia coli DNA polymerase I (Klenow fragment). , 2002, Biochemistry.

[69]  E. Seeberg,et al.  Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA. , 2002, Nucleic acids research.

[70]  S. Mitra,et al.  Identification and Characterization of a Novel Human DNA Glycosylase for Repair of Cytosine-derived Lesions* , 2002, The Journal of Biological Chemistry.

[71]  M. Saparbaev,et al.  Alternative nucleotide incision repair pathway for oxidative DNA damage , 2002, Nature.

[72]  C. Burrows,et al.  Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model. , 2001, Chemical research in toxicology.

[73]  C. Iden,et al.  Characterization of a cross-linked DNA-Endonuclease VIII repair complex by electrospray ionization mass spectrometry , 2000, Journal of the American Society for Mass Spectrometry.

[74]  H. Aburatani,et al.  Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[75]  O. Sidorkina,et al.  Role of the N-terminal Proline Residue in the Catalytic Activities of the Escherichia coli Fpg Protein* , 2000, The Journal of Biological Chemistry.

[76]  C. Burrows,et al.  Characterization of spiroiminodihydantoin as a product of one-electron oxidation of 8-Oxo-7,8-dihydroguanosine. , 2000, Organic letters.

[77]  E. Seeberg,et al.  Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[78]  C. Burrows,et al.  Insertion of dGMP and dAMP during in vitro DNA synthesis opposite an oxidized form of 7,8-dihydro-8-oxoguanine. , 1999, Nucleic acids research.

[79]  E. Seeberg,et al.  Opposite base‐dependent reactions of a human base excision repair enzyme on DNA containing 7,8‐dihydro‐8‐oxoguanine and abasic sites , 1997, The EMBO journal.

[80]  C. Desmaze,et al.  Cloning and characterization of hOGG1, a human homolog of the OGG1 gene of Saccharomyces cerevisiae. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[81]  J. Essigmann,et al.  Characterization of a mammalian homolog of the Escherichia coli MutY mismatch repair protein , 1995, Molecular and cellular biology.

[82]  H. Maki,et al.  Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. , 1993, The Journal of biological chemistry.

[83]  K. Johnson.  An Update. , 1984, Journal of food protection.