How does the extracellular matrix direct gene expression?

Abstract Based on the existing literature, a model is presented that postulates a “dynamic reciprocity” between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the nuclear matrix on the other hand. The ECM is postulated to exert physical and chemical influences on the geometry and the biochemistry of the cell via transmembrane receptors so as to alter the pattern of gene expression by changing the association of the cytoskeleton with the mRNA and the interaction of the chromatin with the nuclear matrix. This, in turn, would affect the ECM, which would affect the cell, which…

[1]  D. Gospodarowicz,et al.  Morphological appearance, growth behavior and migratory activity of human tumor cells maintained on extracellular matrix versus plastic , 1980, Cell.

[2]  D. Levitt,et al.  Chapter 4 Concepts and Mechanisms of Cartilage Differentiation , 1974 .

[3]  M. Bissell The differentiated state of normal and malignant cells or how to define a "normal" cell in culture. , 1981, International review of cytology.

[4]  Kenneth M. Yamada,et al.  Cell surface protein decreases microvilli and ruffles on transformed mouse and chick cells , 1976, Cell.

[5]  J. Gordon,et al.  The basal lamina of the postnatal mammary epithelium contains glycosaminoglycans in a precise ultrastructural organization. , 1980, Developmental biology.

[6]  E. Turley The control of adrenocortical cytodifferentiation by extracellular matrix. , 1980, Differentiation; research in biological diversity.

[7]  N. K. Wessells,et al.  Mammalian lung development: interactions in primordium formation and bronchial morphogenesis. , 1970, The Journal of experimental zoology.

[8]  M. Raizada,et al.  Alteration of insulin binding and cytoskeletal organization in cultured fibroblasts by tertiary amine local anesthetics. , 1979, Journal of supramolecular structure.

[9]  M. Prentki,et al.  Actin microfilaments, cell shape, and secretory processes in isolated rat hepatocytes. Effect of phalloidin and cytochalasin D , 1979, The Journal of cell biology.

[10]  B. Toole Solubility of Collagen Fibrils formed in vitro in the Presence of Sulphated Acid Mucopolysaccharide-protein , 1969, Nature.

[11]  B. Öbrink The Influence of Glycosaminoglycans on the Formation of Fibers from Monomeric Tropocollagen in vitro , 1973 .

[12]  E. Hay,et al.  SECRETION OF COLLAGEN BY CORNEAL EPITHELIUM , 1973, The Journal of cell biology.

[13]  B. Geiger A 130K protein from chicken gizzard: Its localization at the termini of microfilament bundles in cultured chicken cells , 1979, Cell.

[14]  G. Cunha,et al.  Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice. , 1980, Endocrinology.

[15]  M. Schliwa,et al.  Structural interaction of cytoskeletal components , 1981, The Journal of cell biology.

[16]  G. Kreibich,et al.  Proteins of rough microsomal membranes related to ribosome binding. II. Cross-linking of bound ribosomes to specific membrane proteins exposed at the binding sites , 1978, The Journal of cell biology.

[17]  R. Reiter,et al.  Depression by hyaluronic acid of glycosaminoglycan synthesis by cultured chick embryo chondrocytes. , 1974, Developmental biology.

[18]  R. Lenk,et al.  A cytoskeletal structure with associated polyribosomes obtained from HeLa cells , 1977, Cell.

[19]  R. Mandell,et al.  Ascorbate induction of collagen synthesis as a means for elucidating a mechanism of quantitative control of tissue-specific function. , 1981, Molecular and Cellular Biology.

[20]  B. Toole Hyaluronate and Hyaluronidase in Morphogenesis and Differentiation , 1973 .

[21]  B. Rollins,et al.  Fibronectin and proteoglycans as determinants of cell-substratum adhesion. , 1979, Journal of supramolecular structure.

[22]  M Rojkind,et al.  Connective tissue biomatrix: its isolation and utilization for long- term cultures of normal rat hepatocytes , 1980, The Journal of cell biology.

[23]  T. Pollard Cytoskeletal functions of cytoplasmic contractile proteins. , 1976, Journal of supramolecular structure.

[24]  R. Minor,et al.  Environmental enhancement of in vitro chondrogenesis. IV. Stimulation of somite chondrogenesis by exogenous chondromucoprotein. , 1973, Developmental biology.

[25]  Sheldon Penman,et al.  Protein synthesis requires cell-surface contact while nuclear events respond to cell shape in anchorage-dependent fibroblasts , 1980, Cell.

[26]  N. K. Wessells,et al.  Effects of collagenase on developing epithelia in vitro: lung, ureteric bud, and pancreas. , 1968, Developmental biology.

[27]  I. Singer The fibronexus: a transmembrane association of fibronectin-containing fibers and bundles of 5 nm microfilaments in hamster and human fibroblasts , 1979, Cell.

[28]  D. Capco,et al.  The nuclear matrix: Three-dimensional architecture and protein composition , 1982, Cell.

[29]  M. Bernfield,et al.  Type I collagen reduces the degradation of basal lamina proteoglycan by mammary epithelial cells , 1981, The Journal of cell biology.

[30]  I. Singer Association of fibronectin and vinculin with focal contacts and stress fibers in stationary hamster fibroblasts , 1982, The Journal of cell biology.

[31]  K. Burridge,et al.  The association of α‐actinin with the plasma membrane , 1980 .

[32]  B. Toole,et al.  The effect of chondroitin sulphate-protein on the formation of collagen fibrils in vitro. , 1968, The Biochemical journal.

[33]  R. Lenk,et al.  The cytoskeletal framework and poliovirus metabolism , 1979, Cell.

[34]  Kenneth M. Yamada,et al.  Isolation and biological characterization of active fragments of the adhesive glycoprotein fibronectin , 1979, Cell.

[35]  N. Rath,et al.  Collagenous bone matrix is a local mitogen , 1979, Nature.

[36]  R. Mecham,et al.  Elastin synthesis by ligamentum nuchae fibroblasts: effects of culture conditions and extracellular matrix on elastin production , 1981, The Journal of cell biology.

[37]  T. Sakakura,et al.  Mesenchyme-dependent morphogenesis and epithelium-specific cytodifferentiation in mouse mammary gland. , 1976, Science.

[38]  M. Bernfield,et al.  ACID MUCOPOLYSACCHARIDE (GLYCOSAMINOGLYCAN) AT THE EPITHELIAL-MESENCHYMAL INTERFACE OF MOUSE EMBRYO SALIVARY GLANDS , 1972, The Journal of cell biology.

[39]  I. Simpson,et al.  Insulin-stimulated translocation of glucose transport systems in the isolated rat adipose cell. Time course, reversal, insulin concentration dependency, and relationship to glucose transport activity. , 1981, The Journal of biological chemistry.

[40]  D. Williams,et al.  Topography and mobility of ribosomes on the surface of isolated endoplasmic reticulum of rat liver. , 1977, Journal of molecular biology.

[41]  D. David [Action and properties of inductive factors proceeding from gastric and heterologous mesenchymes]. , 1972, Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen.

[42]  R. Hynes Cell surface proteins and malignant transformation. , 1976, Biochimica et biophysica acta.

[43]  B. Toole,et al.  Hyaluronate production and removal during corneal development in the chick. , 1971, Developmental biology.

[44]  B. Toole Hyaluronate turnover during chondrogenesis in the developing chick limb and axial skeleton. , 1972, Developmental biology.

[45]  E. Zwilling Ectoderm — mesoderm relationship in the development of the chick embryo limb bud , 1955 .

[46]  G. Gibson,et al.  Effects of matrix macromolecules on chondrocyte gene expression: synthesis of a low molecular weight collagen species by cells cultured within collagen gels , 1982, The Journal of cell biology.

[47]  R. Kosher,et al.  Stimulation of in vitro somite chondrogenesis by procollagen and collagen , 1975, Nature.

[48]  B. Toole Binding and precipitation of soluble collagens by chick embryo cartilage proteoglycan. , 1976, The Journal of biological chemistry.

[49]  J. Small,et al.  Direct visualization of the 10-nm (100-A)-filament network in whole and enucleated cultured cells. , 1978, Journal of cell science.

[50]  B. L. Granger,et al.  Structural associations of synemin and vimentin filaments in avian erythrocytes revealed by immunoelectron microscopy , 1982, Cell.

[51]  I. Singer,et al.  A transmembrane relationship between fibronectin and vinculin (130 kd protein): Serum modulation in normal and transformed hamster fibroblasts , 1981, Cell.

[52]  C. B. McLoughlin The Importance of Mesenchymal Factors in the Differentiation of Chick Epidermis: II. Modification of Epidermal Differentiation by Contact with Different Types of Mesenchyme , 1961 .

[53]  S. Penman,et al.  Interaction of the Cytoskeletal Framework with Acetylcholine Receptor on the Surface of Embryonic Muscle Cells in Culture Labeling of Acetylcholine Receptor Preparation of Triton X-100 Cytoskeletons , 1982 .

[54]  Keith Burridge,et al.  α-Actinin: Immunofluorescent localization of a muscle structural protein in nonmuscle cells , 1975, Cell.

[55]  B. Hogan,et al.  Incorporation into Reichert's membrane of laminin-like extracellular proteins synthesized by parietal endoderm cells of the mouse embryo. , 1980, Developmental biology.

[56]  E. Hay,et al.  Stimulation of corneal differentiation by interaction between cell surface and extracellular matrix. II. Further studies on the nature and site of transfilter "induction". , 1976, Developmental biology.

[57]  E. Hay Development of the vertebrate cornea. , 1980, International review of cytology.

[58]  E. Lazarides Intermediate filaments as mechanical integrators of cellular space , 1980, Nature.

[59]  E. Hay,et al.  Secretion of collagenous stroma by isolated epithelium grown in vitro. , 1971, Experimental cell research.

[60]  J. Gabrion,et al.  Influence of collagen gel on the orientation of epithelial cell polarity: follicle formation from isolated thyroid cells and from preformed monolayers , 1981, The Journal of cell biology.

[61]  R. Goldman,et al.  Biochemical and immunological analysis of rapidly purified 10-nm filaments from baby hamster kidney (BHK-21) cells , 1978, The Journal of cell biology.

[62]  D. Newsome In vitro stimulation of cartilage in embryonic chick neural crest cells by products of rentinal pigmented epithelium. , 1976, Developmental biology.

[63]  D. Gospodarowicz,et al.  Determination of cellular shape by the extracellular matrix and its correlation with the control of cellular growth. , 1978, Cancer research.

[64]  E. Pearlstein Plasma membrane glycoprotein which mediates adhesion of fibroblasts to collagen , 1976, Nature.

[65]  B. Hogan High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes. , 1980, Developmental biology.

[66]  T. Oegema,et al.  The effect of proteoglycans on the formation of fibrils from collagen solutions. , 1975, Archives of biochemistry and biophysics.

[67]  E. Davidson DIFFERENTIATION IN MONOLAYER TISSUE CULTURE CELLS. , 1964, Advances in genetics.

[68]  M. Bissell,et al.  Glucose metabolite patterns as markers of functional differentiation in freshly isolated and cultured mouse mammary epithelial cells. , 1981, Experimental cell research.

[69]  C. S. Izzard,et al.  Cell-to-substrate contacts in living fibroblasts: an interference reflexion study with an evaluation of the technique. , 1976, Journal of cell science.

[70]  G. Kreibich,et al.  Proteins of rough microsomal membranes related to ribosome binding. I. Identification of ribophorins I and II, membrane proteins characteristics of rough microsomes , 1978, The Journal of cell biology.

[71]  M. Derby Analysis of glycosaminoglycans within the extracellular environments encountered by migrating neural crest cells. , 1978, Developmental biology.

[72]  M. Abercrombie,et al.  Contact inhibition and malignancy , 1979, Nature.

[73]  T. Ji,et al.  Cross-linking of fibronectin to sulfated proteoglycans at the cell surface , 1979, Cell.

[74]  J. W. Saunders,et al.  The origin of pattern and feather germ tract specificity , 1957 .

[75]  P. Kraemer,et al.  Growth and biochemical characteristics of a detachment variant of CHO cells , 1977, Journal of cellular physiology.

[76]  E. Engvall,et al.  Binding of soluble form of fibroblast surface protein, fibronectin, to collagen , 1977, International journal of cancer.

[77]  A. Levitzki,et al.  Hormone‐receptor‐adenylate cyclase interactions , 1979, FEBS letters.

[78]  G. Nicolson Topographic display of cell surface components and their role in transmembrane signaling. , 1979, Current Topics in Developmental Biology.

[79]  E. Hay,et al.  Control of corneal differentiation by extracellular materials. Collagen as a promoter and stabilizer of epithelial stroma production. , 1974, Developmental biology.

[80]  K. Porter,et al.  Microtrabecular lattice of the cytoplasmic ground substance. Artifact or reality , 1979, The Journal of cell biology.

[81]  H. Rubin,et al.  Density Dependent Inhibition of Cell Growth in Culture , 1967, Nature.

[82]  B. Spooner,et al.  Collagen involvement in branching morphogenesis of embryonic lung and salivary gland. , 1980, Developmental biology.

[83]  E. Hay,et al.  Secretion of collagen by corneal epithelium. II. Effect of the underlying substratum on secretion and polymerization of epithelial products. , 1974, The Journal of experimental zoology.

[84]  K. Dellagi,et al.  Redistribution of intermediate filaments during capping of lymphocyte surface molecules , 1982, Nature.

[85]  D. Jackson,et al.  Nuclear organization — does the sub-structure play a crucial role? , 1982 .

[86]  P. Kraemer,et al.  Elevated cell-surface hyaluronate in substrate-attached cells. , 1978, Experimental cell research.

[87]  R. Hynes,et al.  Relationships between fibronectin (LETS protein) and actin , 1978, Cell.

[88]  P. Harrison,et al.  Co-expression of differentiation markers in hybrids between friend cells and lymphoid cells and the influence of the cell shape , 1980, Cell.

[89]  P. Benya,et al.  Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels , 1982, Cell.

[90]  M. Abercrombie,et al.  Observations on the social behaviour of cells in tissue culture. I. Speed of movement of chick heart fibroblasts in relation to their mutual contacts. , 1953, Experimental cell research.

[91]  M. Bernfield,et al.  DEPENDENCE OF SALIVARY EPITHELIAL MORPHOLOGY AND BRANCHING MORPHOGENESIS UPON ACID MUCOPOLYSACCHARIDE-PROTEIN (PROTEOGLYCAN) AT THE EPITHELIAL SURFACE , 1972, The Journal of cell biology.

[92]  L. Liotta,et al.  Basement membrane collagen requirements for attachment and growth of mammary epithelium. , 1979, Experimental cell research.

[93]  H. Kleinman,et al.  Role of collagenous matrices in the adhesion and growth of cells , 1981, The Journal of cell biology.

[94]  D. Bennett,et al.  Reconstitution of branching tubules from two cloned mammary cell types in culture. , 1981, Developmental biology.

[95]  G. Nicolson Transmembrane control of the receptors on normal and tumor cells. I. Cytoplasmic influence over surface components. , 1976, Biochimica et biophysica acta.

[96]  N. Hirokawa,et al.  Cross-linker system between neurofilaments, microtubules and membranous organelles in frog axons revealed by the quick-freeze, deep-etching method , 1982, The Journal of cell biology.

[97]  I. Pastan,et al.  Microfilament bundles and cell shape are related to adhesiveness to substratum and are dissociable from growth control in cultured fibroblasts , 1977, Cell.

[98]  S. Burwen,et al.  Secretory function of lactating mouse mammary epithelial cells cultured on collagen gels. , 1980, Experimental cell research.

[99]  G. Michalopoulos,et al.  Ultrastructure of adult rat hepatocytes cultured on floating collagen membranes. , 1978, Cancer research.

[100]  N. Vasan,et al.  Somite chondrogenesis in vitro. Stimulation by exogenous extracellular matrix components. , 1978, Developmental biology.

[101]  R. Crystal,et al.  Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin. , 1981, The Journal of biological chemistry.

[102]  Kenneth M. Yamada,et al.  Fibronectins—adhesive glycoproteins of cell surface and blood , 1978, Nature.

[103]  R. Praus,et al.  Glycosaminoglycans in the Developing Chicken Cornea , 1971 .

[104]  B. Toole,et al.  The extracellular matrix of the regenerating newt limb: synthesis and removal of hyaluronate prior to differentiation. , 1971, Developmental biology.

[105]  E. Ruoslahti,et al.  Location of the cell-attachment site in fibronectin with monoclonal antibodies and proteolytic fragments of the molecule , 1981, Cell.

[106]  D. Mosher,et al.  High molecular weight, cell surface-associated glycoprotein (fibronectin) lost in maglinant transformation , 1978 .

[107]  G. Michalopoulos,et al.  Primary culture of parenchymal liver cells on collagen membranes. Morphological and biochemical observations. , 1975, Experimental cell research.

[108]  A. Ben-Ze'ev,et al.  Altered translatability of messenger RNA from suspended anchorage-dependent fibroblasts: Reversal upon cell attachment to a surface , 1978, Cell.

[109]  M. Kedinger,et al.  Role of epithelial--mesenchymal interactions in the ontogenesis of intestinal brush-border enzymes. , 1981, Developmental biology.

[110]  D. Rifkin,et al.  Actin-containing cables within anchorage-dependent rat embryo cells are dissociated by plasmin and trypsin , 1975, Cell.

[111]  M. Bernfield Collagen synthesis during epitheliomesenchymal interactions. , 1970, Developmental biology.

[112]  E. Engvall,et al.  Fibronectin: current concepts of its structure and functions. , 1980, Collagen and related research.

[113]  E. Ruoslahti,et al.  Disappearance of a major cell‐type specific surface glycoprotein antigen (SF) after transformation of fibroblasts by rous sarcoma virus , 1974, International journal of cancer.

[114]  R. Hynes,et al.  Restoration of normal morphology, adhesion and cytoskeleton in transformed cells by addition of a transformation-sensitive surface protein , 1977, Cell.

[115]  R. Reiter,et al.  The influence of epithelia on cartilage and loose connective tissue formation by limb mesenchyme cultures. , 1981, Developmental biology.

[116]  A. Ben-Ze'ev,et al.  The control of mRNA production, translation and turnover in suspended and reattached anchorage-dependent fibroblasts , 1978, Cell.

[117]  G. Nicolson Cis- and trans-membrane control of cell surface topography. , 1973, Journal of supramolecular structure.

[118]  P. Bornstein,et al.  ORGANIZATION OF EXTRACELLULAR PROTEINS ON THE CONNECTIVE TISSUE CELL SURFACE: RELEVANCE TO CELL‐MATRIX INTERACTIONS IN VITRO AND IN VIVO * , 1978, Annals of the New York Academy of Sciences.

[119]  A. Ben-Ze'ev,et al.  The outer boundary of the cytoskeleton: a lamina derived from plasma membrane proteins , 1979, Cell.

[120]  H. Slavkin,et al.  Epithelial-mesenchyme interactions during odontogenesis. IV. Morphological evidence for direct heterotypic cell-cell contacts. , 1976, Developmental biology.

[121]  K. Porter,et al.  Stereo high-voltage electron microscopy of whole cells of the human diploid line, WI-38. , 1976, The American journal of anatomy.

[122]  A. Moscona,et al.  Analysis of feather germ formation in the embryo and vitro, in normal development and in skin treated with hydrocortisone. , 1972, The Journal of experimental zoology.

[123]  M. Bissell,et al.  Interrelationship of glycogen metabolism and lactose synthesis in mammary epithelial cells of mice. , 1980, The Biochemical journal.

[124]  W. Birchmeier Fibroblast's focal contacts , 1981 .

[125]  G M Edelman,et al.  Surface modulation in cell recognition and cell growth. , 1976, Science.

[126]  E. Hay,et al.  Secretion of collagen by embryonic neuroepithelium at the time of spinal cord--somite interaction. , 1971, Developmental biology.

[127]  F. Peebles ON THE INTERCHANGE OF THE LIMBS OF THE CHICK BY TRANSPLANTATION , 1910 .

[128]  K. Crossin,et al.  Evidence that microtubule depolymerization early in the cell cycle is sufficient to initiate DNA synthesis , 1981, Cell.

[129]  J. Schlessinger The mechanism and role of hormone-induced clustering of membrane receptors , 1980 .

[130]  K. Yamada,et al.  Characterization of fibronectin interactions with glycosaminoglycans and identification of active proteolytic fragments. , 1980, The Journal of biological chemistry.

[131]  K. Kratochwil Organ specificity in mesenchymal induction demonstrated in the embryonic development of the mammary gland of the mouse. , 1969, Developmental biology.

[132]  E. Hay,et al.  Response of basal epithelial cell surface and Cytoskeleton to solubilized extracellular matrix molecules , 1981, The Journal of cell biology.

[133]  S J Singer,et al.  The molecular organization of membranes. , 1974, Annual review of biochemistry.

[134]  N. K. Wessells Mammalian lung development: interactions in formation and morphogenesis of tracheal buds. , 1970, The Journal of experimental zoology.

[135]  S. Penman,et al.  The spatial distribution of polyribosomes in 3T3 cells and the associated assembly of proteins into the skeletal framework , 1980, Cell.

[136]  K. Hedman,et al.  External fibronectin of cultured human fibroblasts is predominantly a matrix protein , 1978, The Journal of cell biology.

[137]  T. Hunter,et al.  Vinculin: A cytoskeletal target of the transforming protein of rous sarcoma virus , 1981, Cell.

[138]  G. Dreyfuss,et al.  Messenger RNA is translated when associated with the cytoskeletal framework in normal and VSV-infected HeLa cells , 1981, Cell.

[139]  R. Hynes,et al.  Effects of cytochalasin B and colchicine on attachment of a major surface protein of fibroblasts. , 1977, Biochimica et biophysica acta.

[140]  G. Michalopoulos,et al.  Hormonal regulation and the effects of glucose on tyrosine aminotransferase activity in adult rat hepatocytes cultured on floating collagen membranes. , 1978, Cancer research.

[141]  J. Emerman,et al.  Substrate properties influencing ultrastructural differentiation of mammary epithelial cells in culture. , 1979, Tissue & cell.

[142]  R. Timpl,et al.  Identification of the sites in collagen alpha-chains that bind serum anti-gelatin factor (cold-insoluble globulin). , 1978, The Biochemical journal.

[143]  A. Chung,et al.  A novel extracellular membrane elaborated by a mouse embryonal carcinoma-derived cell line. , 1977, Biochemical and biophysical research communications.

[144]  E. Hay,et al.  GLYCOSAMINOGLYCAN SYNTHESIS BY EMBRYONIC INDUCTORS: NEURAL TUBE, NOTOCHORD, AND LENS , 1974, The Journal of cell biology.

[145]  J. Folkman,et al.  Influence of geometry on control of cell growth. , 1975, Biochimica et biophysica acta.

[146]  R. Timpl,et al.  Shift in collagen type as an early response to induction of the metanephric mesenchyme , 1981, The Journal of cell biology.

[147]  M. Bissell,et al.  Synergism between anti-microtubule agents and growth stimulants in enhancement of cell cycle traverse , 1977, Nature.

[148]  J. W. Dodson On the nature of tissue interactions in embryonic skin , 1963 .

[149]  M J Bissell,et al.  Cell shape and hexose transport in normal and virus-transformed cells in culture. , 2010, Journal of supramolecular structure.

[150]  P. Bornstein,et al.  Isolation of a collagen-binding fragment from fibronectin and cold-insoluble globulin. , 1979, The Journal of biological chemistry.

[151]  W. E. Gordon,et al.  Immunofluorescent and ultrastructural studies of "sarcomeric" units in stress fibers of cultured non-muscle cells. , 1978, Experimental cell research.

[152]  J. Folkman,et al.  Role of cell shape in growth control , 1978, Nature.

[153]  B. Vogelstein,et al.  The ovalbumin gene is associated with the nuclear matrix of chicken oviduct cells , 1982, Cell.

[154]  G. Gabbiani,et al.  The role of microfilaments in the response of adrenal tumor cells to adrenocorticotropic hormone. , 1979, The Journal of biological chemistry.