From Enzymatic Adaptation to Allosteric Transitions

The research by my collaborators and myself since 1945 has been carried out entirely at the Pasteur Institute. This work has received decisive assistance from numerous institutions, in particular the Centre National de la Recherche Scientifique, the Rockefeller Foundation of New York, the National Science Foundation and the National Institutes of Health of the United States, the Jane Coffin Childs Memorial Fund, the Commissariat � l'Energie Atomique, and the Dέlέgation Gέnέrale ά la Recherche Scientifique et Technique. A donation by MIesdames Edouard de Rothschild and Bethsabee de Rothschild permitted, in large part, the establishment in 1954 of the Department of Cellular Biochemistry at the Pasteur Institute

[1]  S. Brenner,et al.  Genetic Code: The ‘Nonsense’ Triplets for Chain Termination and their Suppression , 1965, Nature.

[2]  J. Monod,et al.  Teleonomic mechanisms in cellular metabolism, growth, and differentiation. , 1961, Cold Spring Harbor symposia on quantitative biology.

[3]  L. Orgel,et al.  Suppression of and complementation among mutants of the regulatory gene of the lactose operon of Escherichia coli. , 1965, Journal of molecular biology.

[4]  A KEPES,et al.  KINETICS OF INDUCED ENZYME SYNTHESIS. DETERMINATION OF THE MEAN LIFE OF GALACTOSIDASE-SPECIFIC MESSENGER RNA. , 1963, Biochimica et biophysica acta.

[5]  Joshua Lederberg,et al.  NOVEL GENOTYPES IN MIXED CULTURES OF BIOCHEMICAL MUTANTS OF BACTERIA , 1946 .

[6]  A. Pardee,et al.  Control of pyrimidine biosynthesis in Escherichia coli by a feed-back mechanism. , 1956, The Journal of biological chemistry.

[7]  J. Monod,et al.  On the enzymic acetylation of isopropyl-β-d-thiogalactoside and its association with galactoside-permease , 1959 .

[8]  J. Changeux,et al.  ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL. , 1965, Journal of molecular biology.

[9]  M. Perutz,et al.  State of Hæmoglobin in Sickle-Cell Anæmia , 1950, Nature.

[10]  A. Kepes Études cinétiques sur la galactoside-perméase d'Escherichia coli , 1960 .

[11]  J. Gerhart,et al.  ASPARTATE TRANSCARBAMYLASE, AN ENZYME DESIGNED FOR FEEDBACK INHIBITION. , 1964, Federation proceedings.

[12]  M. Pollock Penicillinase adaptation in B. cereus; adaptive enzyme formation in the absence of free substrate. , 1950, British journal of experimental pathology.

[13]  A. White,et al.  The Dynamic State of Body Constituents , 1942, Nutrition reviews.

[14]  C. Cori,et al.  THE ROLE OF ADENYLIC ACID IN THE ACTIVATION OF PHOSPHORYLASE. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[15]  E. Stadtman,et al.  Cumulative feedback inhibition in the multiple end product regulation of glutamine synthetase activity in Escherichiacoli , 1964 .

[16]  J. Wyman,et al.  Further studies on the oxygen equilibrium of hemoglobin. , 1950, The Journal of biological chemistry.

[17]  R. K. Robins,et al.  Studies on 4APP: antineoplastic action in vitro. , 1956, Science.

[18]  M. Cohn,et al.  Immunochemical Studies with the β-Galactosidase and Structurally Related Proteins of Escherichia Coli , 1952, The Journal of Immunology.

[19]  J. Monod,et al.  [The role of the inducible alleles and the constrtutive alleles in the synthesis of beta-galactosidase in zygotes of Escherichia coli]. , 1958, Comptes rendus hebdomadaires des seances de l'Academie des sciences.

[20]  O. Gaebler,et al.  Enzymes: Units of Biological Structure and Function , 1956 .

[21]  J. Changeux,et al.  Allosteric proteins and cellular control systems. , 1963, Journal of molecular biology.

[22]  H. E. Umbarger,et al.  Evidence for a negative-feedback mechanism in the biosynthesis of isoleucine. , 1956, Science.

[23]  J. Monod,et al.  [Galactoside-permease of Escherichia coli]. , 1956, Annales de l'Institut Pasteur.

[24]  Changeux Jp [ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHESIZED L-THREONINE DEAMINASE. VI. GENERAL DISCUSSION]. , 1965 .

[25]  G. Cohen Regulation of enzyme activity in microorganisms. , 1965, Annual review of microbiology.

[26]  D. Shemin The Dynamic State of Body Constituents By Rudolf Schoenheimer. Harvard University Press, Cambridge, Massachusetts. 78 pages; 6 figures and 16 tables. Price $1.75 , 1942 .

[27]  E. P. Kennedy,et al.  Specific labeling and partial purification of the M protein, a component of the beta-galactoside transport system of Escherichia coli. , 1965, Proceedings of the National Academy of Sciences of the United States of America.

[28]  Changeux Jp [ON THE ALLOSTERIC PROPERTIES OF BIOSYNTHETIC L-THREONINE DEAMINASE. 3. INTERPRETATION OF THE INHIBITORY EFFECT OF L-ISOLEUCINE: STERIC HINDRANCE OR ALLOSTERIC EFFECT]. , 1964 .

[29]  S. Benzer,et al.  A change from nonsense to sense in the genetic code. , 1962, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Melvin Cohn,et al.  Sur la biosynthese de la β-galactosidase (lactase) chez Escherichia coli. La specificite de l'induction☆ , 1951 .

[31]  A. Kepes Kinetic Analysis of the Early Events in Induced Enzyme Synthesis , 1963 .

[32]  J. Gerhart,et al.  The Effect of the Feedback Inhibitor, CTP, on Subunit Interactions in Aspartate Transcarbamylase , 1963 .

[33]  Jacques Monod,et al.  The genetic control and cytoplasmic expression of “Inducibility” in the synthesis of β-galactosidase by E. coli , 1959 .

[34]  A. Garen,et al.  Base Composition of Nonsense Condons in E. coli: Evidence from Amino-Acid Substitutions at a Tryptophan Site in Alkaline Phosphatase , 1965, Nature.

[35]  J. Changeux,et al.  The feedback control mechanisms of biosynthetic L-threonine deaminase by L-isoleucine. , 1961, Cold Spring Harbor symposia on quantitative biology.

[36]  M. Delbrück,et al.  Mutations of Bacteria from Virus Sensitivity to Virus Resistance. , 1943, Genetics.

[37]  F. Jacob,et al.  Genetics of the bacterial cell. , 1966, Science.

[38]  J. Gerhart,et al.  The enzymology of control by feedback inhibition. , 1962, The Journal of biological chemistry.

[39]  J. Monod,et al.  [Genes of structure and genes of regulation in the biosynthesis of proteins]. , 1959, Comptes rendus hebdomadaires des seances de l'Academie des sciences.

[40]  G. Gamow Possible Relation between Deoxyribonucleic Acid and Protein Structures , 1954, Nature.

[41]  D. Hogness,et al.  Studies on the induced synthesis of beta-galactosidase in Escherichia coli: the kinetics and mechanism of sulfur incorporation. , 1955, Biochimica et biophysica acta.

[42]  J. Monod,et al.  [The kinetics of the biosynthesis of beta-galactosidase in Escherichia coli as a function of growth]. , 1952, Biochimica et biophysica acta.

[43]  M. Cohn,et al.  NON-INDUCIBLE MUTANTS OF THE REGULATOR GENE IN THE "LACTOSE" SYSTEM OF ESCHERICHIA COLI. , 1964, Journal of molecular biology.

[44]  Effet des analogues de la L-thréonine et de la L-isoleucine sur la L-thréonine désaminase , 1962 .

[45]  J. Monod,et al.  Purification et propriétés de la β-galactosidase (lactase) d'escherichia coli , 1951 .