Recent Progress in Diazirine‐Based Photoaffinity Labeling

As a result of recent developments in molecular biology, the investigation of biofunctional machinery at ligand-accepting interfaces has become one of the challenging and important subjects in the post-genome field. The technique of photoaffinity labeling has become increasingly appreciated as a powerful methodology for this purpose. This microreviewfocuses on the synthesis of 3-phenyl-3-(trifluoromethyl)diazirine, one of the most promising photophores, and its application to biomolecules.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

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