Mammalian short palate lung and nasal epithelial clone 1 (SPLUNC1) in pH-dependent airway hydration.

[1]  M. Redinbo,et al.  Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. , 2013, American journal of physiology. Lung cellular and molecular physiology.

[2]  L. Betts,et al.  Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways , 2013, Proceedings of the National Academy of Sciences.

[3]  R. Bowler,et al.  Human Neutrophil Elastase Degrades SPLUNC1 and Impairs Airway Epithelial Defense against Bacteria , 2013, PloS one.

[4]  D. Hill,et al.  A Periciliary Brush Promotes the Lung Health by Separating the Mucus Layer from Airway Epithelia , 2012, Science.

[5]  M. Redinbo,et al.  Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways. , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[6]  A. Alli,et al.  Cathepsin B Is Secreted Apically from Xenopus 2F3 Cells and Cleaves the Epithelial Sodium Channel (ENaC) to Increase Its Activity* , 2012, The Journal of Biological Chemistry.

[7]  S. H. Kim,et al.  Regulation of sodium transport in the inner ear , 2011, Hearing Research.

[8]  L. Gakhar,et al.  PLUNC: a multifunctional surfactant of the airways. , 2011, Biochemical Society transactions.

[9]  Y. Di,et al.  Functional roles of SPLUNC1 in the innate immune response against Gram-negative bacteria. , 2011, Biochemical Society transactions.

[10]  D. Bratton,et al.  SPLUNC1 promotes lung innate defense against Mycoplasma pneumoniae infection in mice. , 2011, The American journal of pathology.

[11]  Douglas C Johnson,et al.  Airway mucus function and dysfunction. , 2011, The New England journal of medicine.

[12]  P. Hwang,et al.  Acid and base secretion in freshly excised nasal tissue from cystic fibrosis patients with ΔF508 mutation , 2011, International forum of allergy & rhinology.

[13]  L. Bakaletz,et al.  The Multifunctional Host Defense Peptide SPLUNC1 Is Critical for Homeostasis of the Mammalian Upper Airway , 2010, PloS one.

[14]  R. Tarran,et al.  SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes , 2010, Channels.

[15]  M. Gentzsch,et al.  The Cystic Fibrosis Transmembrane Conductance Regulator Impedes Proteolytic Stimulation of the Epithelial Na+ Channel*♦ , 2010, The Journal of Biological Chemistry.

[16]  N. Dokholyan,et al.  Regulation of the epithelial Na+ channel and airway surface liquid volume by serine proteases , 2010, Pflügers Archiv - European Journal of Physiology.

[17]  J. Olsen,et al.  SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage , 2009, Proceedings of the National Academy of Sciences.

[18]  B. Rossier,et al.  Activation of the epithelial sodium channel (ENaC) by serine proteases. , 2009, Annual review of physiology.

[19]  N. Alexis,et al.  Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? , 2008, American journal of physiology. Lung cellular and molecular physiology.

[20]  Gui-yuan Li,et al.  Effect of SPLUNC1 protein on the Pseudomonas aeruginosa and Epstein-Barr virus , 2008, Molecular and Cellular Biochemistry.

[21]  S. Cross,et al.  Differential epithelial expression of the putative innate immune molecule SPLUNC1 in Cystic Fibrosis , 2007, Respiratory research.

[22]  R. Hughey,et al.  Role of proteolysis in the activation of epithelial sodium channels , 2007, Current opinion in nephrology and hypertension.

[23]  R. Tarran,et al.  Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia , 2006, The Journal of general physiology.

[24]  T. Luider,et al.  Proteomic analysis of nasal cells from cystic fibrosis patients and non‐cystic fibrosis control individuals: Search for novel biomarkers of cystic fibrosis lung disease , 2006, Proteomics.

[25]  L. Pannell,et al.  Identification of human nasal mucous proteins using proteomics , 2005, Proteomics.

[26]  R. Boucher,et al.  Neutrophil elastase activates near-silent epithelial Na+ channels and increases airway epithelial Na+ transport. , 2005, American journal of physiology. Lung cellular and molecular physiology.

[27]  Richard C Boucher,et al.  Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice , 2004, Nature Medicine.

[28]  Richard C Boucher,et al.  Abnormal surface liquid pH regulation by cultured cystic fibrosis bronchial epithelium , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  R. Gibson,et al.  Pathophysiology and management of pulmonary infections in cystic fibrosis. , 2003, American journal of respiratory and critical care medicine.

[30]  Xiaoling Li,et al.  Identification of tissue‐specific genes in nasopharyngeal epithelial tissue and differentially expressed genes in nasopharyngeal carcinoma by suppression subtractive hybridization and cDNA microarray , 2003, Genes, chromosomes & cancer.

[31]  P. Davis,et al.  State of the Art: Why do the lungs of patients with cystic fibrosis become infected and why can't they clear the infection? , 2003, Respiratory research.

[32]  R. Wu,et al.  Molecular Cloning and Characterization of spurt, a Human Novel Gene That Is Retinoic Acid-inducible and Encodes a Secretory Protein Specific in Upper Respiratory Tracts* , 2003, The Journal of Biological Chemistry.

[33]  C. Bingle,et al.  PLUNC: a novel family of candidate host defence proteins expressed in the upper airways and nasopharynx. , 2002, Human molecular genetics.

[34]  J. Chao,et al.  Regulation of the Epithelial Sodium Channel by Serine Proteases in Human Airways* , 2002, The Journal of Biological Chemistry.

[35]  M. Knowles,et al.  Mucus clearance as a primary innate defense mechanism for mammalian airways. , 2002, The Journal of clinical investigation.

[36]  C. Delacourt,et al.  Protection against acute lung injury by intravenous or intratracheal pretreatment with EPI-HNE-4, a new potent neutrophil elastase inhibitor. , 2002, American journal of respiratory cell and molecular biology.

[37]  Richard C Boucher,et al.  Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients. , 2002, The Journal of clinical investigation.

[38]  J. Gatzy,et al.  The Relative Roles of Passive Surface Forces and Active Ion Transport in the Modulation of Airway Surface Liquid Volume and Composition , 2001, The Journal of general physiology.

[39]  R. Tarran,et al.  The CF salt controversy: in vivo observations and therapeutic approaches. , 2001, Molecular cell.

[40]  A. Tanigami,et al.  Isolation of a novel human lung‐specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non‐small‐cell lung cancer , 2001, International journal of cancer.

[41]  R. Tuan,et al.  Differential Display Identification of plunc, a Novel Gene Expressed in Embryonic Palate, Nasal Epithelium, and Adult Lung* , 1999, The Journal of Biological Chemistry.

[42]  M. King,et al.  Effects of dextran on tracheal mucociliary velocity in dogs in vivo. , 1999, Pulmonary pharmacology & therapeutics.

[43]  S. Randell,et al.  Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease , 1998, Cell.

[44]  M. Knowles,et al.  Ion composition of airway surface liquid of patients with cystic fibrosis as compared with normal and disease-control subjects. , 1997, The Journal of clinical investigation.

[45]  D Eisenberg,et al.  Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. , 1997, Science.

[46]  M. Konstan,et al.  Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation. , 1994, American journal of respiratory and critical care medicine.

[47]  R. Boucher,et al.  Human airway ion transport. Part two. , 1994, American journal of respiratory and critical care medicine.

[48]  T. Machen,et al.  Bicarbonate conductance and pH regulatory capability of cystic fibrosis transmembrane conductance regulator. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M. Welsh,et al.  Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis , 1993, Cell.

[50]  L. Cantley,et al.  Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. , 1986, The Journal of clinical investigation.

[51]  J. Brain,et al.  Respiratory Defense Mechanisms , 1977 .

[52]  Ichael,et al.  PULMONARY EPITHELIAL SODIUM-CHANNEL DYSFUNCTION AND EXCESS AIRWAY LIQUID IN PSEUDOHYPOALDOSTERONISM , 2000 .

[53]  R. Boucher Human airway ion transport. Part one. , 1994, American journal of respiratory and critical care medicine.