Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer

[1]  R. Bicknell,et al.  Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  I. Bièche,et al.  Epigenetic inactivation of SLIT3 and SLIT1 genes in human cancers , 2004, British Journal of Cancer.

[3]  M. Esteller,et al.  Histone deacetylase inhibitors: Understanding a new wave of anticancer agents , 2004, International journal of cancer.

[4]  G. Rouleau,et al.  A novel locus for pure recessive hereditary spastic paraplegia maps to 10q22.1‐10q24.1 , 2004, Annals of neurology.

[5]  C. Zahnow,et al.  Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. , 2004, Cancer cell.

[6]  T. Rabbitts,et al.  Targeted Disruption of the 3p12 Gene, Dutt1/Robo1, Predisposes Mice to Lung Adenocarcinomas and Lymphomas with Methylation of the Gene Promoter , 2004, Cancer Research.

[7]  D. Bredesen,et al.  Netrin-1 controls colorectal tumorigenesis by regulating apoptosis , 2004, Nature.

[8]  D. Bilder.  Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. , 2004, Genes & development.

[9]  J. Minna,et al.  Semaphorin 3B (SEMA3B) induces apoptosis in lung and breast cancer, whereas VEGF165 antagonizes this effect. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  M. Lübbert,et al.  DNA Methylation as a Therapeutic Target in Hematologic Disorders: Recent Results in Older Patients with Myelodysplasia and Acute Myeloid Leukemia , 2004, International journal of hematology.

[11]  Y. Rao,et al.  Modulation of inflammation by slit protein in vivo in experimental crescentic glomerulonephritis. , 2004, The American journal of pathology.

[12]  Lin He,et al.  Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population. , 2004, Genome research.

[13]  Yoonsung Kang,et al.  Molecular genetic characterization of a Korean split hand/split foot malformation (SHFM). , 2004, Molecules and cells.

[14]  F. Balkwill.  The significance of cancer cell expression of the chemokine receptor CXCR4. , 2004, Seminars in cancer biology.

[15]  W. Andrews,et al.  Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding , 2004, Molecular and Cellular Neuroscience.

[16]  M. Tessier-Lavigne,et al.  SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site. , 2004, Developmental cell.

[17]  F. Murakami,et al.  The Divergent Robo Family Protein Rig-1/Robo3 Is a Negative Regulator of Slit Responsiveness Required for Midline Crossing by Commissural Axons , 2004, Cell.

[18]  Y. Rao,et al.  Slit Protein-mediated Inhibition of CXCR4-induced Chemotactic and Chemoinvasive Signaling Pathways in Breast Cancer Cells* , 2004, Journal of Biological Chemistry.

[19]  A. Procopio,et al.  Cross‐talk between vascular endothelial growth factor and semaphorin‐3A pathway in the regulation of normal and malignant mesothelial cell proliferation , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[20]  M. Yao,et al.  SLIT2 promoter methylation analysis in neuroblastoma, Wilms' tumour and renal cell carcinoma , 2004, British Journal of Cancer.

[21]  James R. Knight,et al.  A Protein Interaction Map of Drosophila melanogaster , 2003, Science.

[22]  J. Herman,et al.  Gene silencing in cancer in association with promoter hypermethylation. , 2003, The New England journal of medicine.

[23]  Christopher A. Jones,et al.  Robo4 is a vascular-specific receptor that inhibits endothelial migration. , 2003, Developmental biology.

[24]  J. Sedor,et al.  Congenital diaphragmatic hernia, kidney agenesis and cardiac defects associated with Slit3-deficiency in mice , 2003, Mechanisms of Development.

[25]  Charis Eng,et al.  Frequent epigenetic inactivation of the SLIT2 gene in gliomas , 2003, Oncogene.

[26]  S. Duan,et al.  Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. , 2003, Cancer cell.

[27]  C. Croce,et al.  Allelic loss on chromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. , 2003, Cancer research.

[28]  Randal P. Babiuk,et al.  A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[29]  G. Pfeifer,et al.  Epigenetic inactivation of the Ras-association domain family 1 (RASSF1A) gene and its function in human carcinogenesis. , 2003, Histology and histopathology.

[30]  Jane Y. Wu,et al.  Slit and robo: expression patterns in lung development. , 2003, Gene expression patterns : GEP.

[31]  D. Morton,et al.  SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. , 2003, Cancer research.

[32]  R. Ravazzolo,et al.  Genetic heterogeneity in inherited spastic paraplegia associated with epilepsy , 2003, American journal of medical genetics. Part A.

[33]  J. Herman,et al.  Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors , 2003, Nature Genetics.

[34]  J. Minna,et al.  SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. , 2002, Cancer research.

[35]  J. Lilien,et al.  Activation of the repulsive receptor Roundabout inhibits N-cadherin-mediated cell adhesion , 2002, Nature Cell Biology.

[36]  D. V. Vactor,et al.  Robo is Abl to block N-Cadherin function , 2002, Nature Cell Biology.

[37]  E. Y. Lee,et al.  Pax-2 interacts with RB and reverses its repression on the promoter of Rig-1, a Robo member. , 2002, Biochemical and biophysical research communications.

[38]  M. Esteller.  CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future , 2002, Oncogene.

[39]  E. Hammond,et al.  Temporal and spatial expression of two isoforms of the Dutt1/Robo1 gene in mouse development , 2002, FEBS letters.

[40]  J. Minna,et al.  Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers , 2002, Oncogene.

[41]  C. Tse,et al.  Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. , 2002, Cancer research.

[42]  Michael Gorn,et al.  Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. , 2002, Genomics.

[43]  Carol A. Mason,et al.  Slit1 and Slit2 Cooperate to Prevent Premature Midline Crossing of Retinal Axons in the Mouse Visual System , 2002, Neuron.

[44]  C. Tse,et al.  Human Semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. , 2002, Cancer research.

[45]  T. Rabbitts,et al.  Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[46]  J. Minna,et al.  Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[47]  Cori Bargmann,et al.  Dynamic regulation of axon guidance , 2001, Nature Neuroscience.

[48]  Y. Rao,et al.  Signal Transduction in Neuronal Migration Roles of GTPase Activating Proteins and the Small GTPase Cdc42 in the Slit-Robo Pathway , 2001, Cell.

[49]  T. Motoyama,et al.  Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer , 2001, British Journal of Cancer.

[50]  J. Jacobs,et al.  Repellent Signaling by Slit Requires the Leucine-Rich Repeats , 2001, The Journal of Neuroscience.

[51]  F. Llambi,et al.  Netrin‐1 acts as a survival factor via its receptors UNC5H and DCC , 2001, The EMBO journal.

[52]  Y. Rao,et al.  The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors , 2001, Nature.

[53]  J. Minna,et al.  Methylation associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours , 2001, Oncogene.

[54]  M. Tessier-Lavigne,et al.  Hierarchical Organization of Guidance Receptors: Silencing of Netrin Attraction by Slit Through a Robo/DCC Receptor Complex , 2001, Science.

[55]  A. Maitra,et al.  Deletions of chromosome 4 occur early during the pathogenesis of colorectal carcinoma. , 2001, Human pathology.

[56]  J. Minna,et al.  The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes. The International Lung Cancer Chromosome 3p21.3 Tumor Suppressor Gene Consortium. , 2000, Cancer research.

[57]  A. Gazdar,et al.  Chromosome 4 deletions are frequent in invasive cervical cancer and differ between histologic variants. , 2000, Gynecologic oncology.

[58]  Chun Xing Li,et al.  Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3 , 2000, Nature Genetics.

[59]  C. Goodman,et al.  Repulsive Axon Guidance Abelson and Enabled Play Opposing Roles Downstream of the Roundabout Receptor , 2000, Cell.

[60]  M. Friedlander,et al.  Molecular genetic analysis of malignant ovarian germ cell tumors. , 2000, Gynecologic oncology.

[61]  E. Brambilla,et al.  Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration. , 2000, The American journal of pathology.

[62]  A. Jauch,et al.  Allelic changes at multiple regions of chromosome 5 are associated with progression of urinary bladder cancer , 2000, The Journal of pathology.

[63]  M. Tessier-Lavigne,et al.  Slit proteins: key regulators of axon guidance, axonal branching, and cell migration , 2000, Current Opinion in Neurobiology.

[64]  J. Minna,et al.  Multiple regions of chromosome 4 demonstrating allelic losses in breast carcinomas. , 1999, Cancer research.

[65]  S. Carr,et al.  Mammalian Homologues of the Drosophila Slit Protein Are Ligands of the Heparan Sulfate Proteoglycan Glypican-1 in Brain* , 1999, The Journal of Biological Chemistry.

[66]  C. Goodman,et al.  Slit Proteins Bind Robo Receptors and Have an Evolutionarily Conserved Role in Repulsive Axon Guidance , 1999, Cell.

[67]  Y. Rao,et al.  Vertebrate Slit, a Secreted Ligand for the Transmembrane Protein Roundabout, Is a Repellent for Olfactory Bulb Axons , 1999, Cell.

[68]  L. Cox,et al.  Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos. , 1999, Developmental biology.

[69]  S. Sakano,et al.  Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. , 1998, Brain research. Molecular brain research.

[70]  J. Bergh,et al.  Homozygous deletions at 3p12 in breast and lung cancer , 1998, Oncogene.

[71]  A. Bateman,et al.  TheDUTT1Gene, a Novel NCAM Family Member Is Expressed in Developing Murine Neural Tissues and Has an Unusually Broad Pattern of Expression , 1998, Molecular and Cellular Neuroscience.

[72]  Marc Tessier-Lavigne,et al.  Roundabout Controls Axon Crossing of the CNS Midline and Defines a Novel Subfamily of Evolutionarily Conserved Guidance Receptors , 1998, Cell.

[73]  M. S. St John,et al.  Understanding human cancer in a fly? , 1997, American journal of human genetics.

[74]  R. Weinberg,et al.  Phenotype of mice lacking functional Deleted in colorectal cancer (Dec) gene , 1997, Nature.

[75]  Marshall W. Anderson,et al.  Homozygous deletions of human chromosome 3p in lung tumors. , 1997, Cancer research.

[76]  S. Naylor,et al.  Isolation of the human semaphorin III/F gene (SEMA3F) at chromosome 3p21, a region deleted in lung cancer. , 1996, Genomics.

[77]  T. Polascik,et al.  Distinct regions of allelic loss on chromosome 4 in human primary bladder carcinoma. , 1995, Cancer research.

[78]  S. Clark,et al.  High sensitivity mapping of methylated cytosines. , 1994, Nucleic acids research.

[79]  C. Goodman,et al.  Mutations affecting growth cone guidance in drosophila: Genes necessary for guidance toward or away from the midline , 1993, Neuron.

[80]  K. Tory,et al.  Molecular characterization of a large homozygous deletion in the small cell lung cancer cell line U2020: A strategy for cloning the putative tumor suppressor gene , 1992, Genes, chromosomes & cancer.

[81]  J. Bergh,et al.  Characterization of the submicroscopic deletion in the small‐cell lung carcinoma (SCLC) cell line U2020 , 1992, Genes, chromosomes & cancer.

[82]  F. Collins,et al.  A submicroscopic homozygous deletion at the D3S3 locus in a cell line isolated from a small cell lung carcinoma , 1990, Genes, chromosomes & cancer.

[83]  B. Vogelstein,et al.  A genetic model for colorectal tumorigenesis , 1990, Cell.

[84]  Kathleen R. Cho,et al.  Identification of a chromosome 18q gene that is altered in colorectal cancers. , 1990, Science.

[85]  M. Ehrlich,et al.  Comparison of bisulfite modification of 5-methyldeoxycytidine and deoxycytidine residues. , 1980, Nucleic acids research.

[86]  A. Knudson,et al.  Mutation and childhood cancer: a probabilistic model for the incidence of retinoblastoma. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[87]  U. Weidle,et al.  Identification of genes associated with enhanced metastasis of a large cell lung carcinoma cell line. , 2003, Anticancer research.

[88]  H. Drabkin,et al.  Semaphorin SEMA3F and VEGF have opposing effects on cell attachment and spreading. , 2003, Neoplasia.

[89]  T. Nagase,et al.  Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. , 2000, DNA research : an international journal for rapid publication of reports on genes and genomes.

[90]  J. Minna,et al.  Deletions of chromosome 4 at multiple sites are frequent in malignant mesothelioma and small cell lung carcinoma. , 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

[91]  W. Yung,et al.  Deletion mapping of chromosome 4 in head and neck squamous cell carcinoma , 1997, Oncogene.

[92]  S. Naylor,et al.  Deletions of the short arm of chromosome 3 in solid tumors and the search for suppressor genes. , 1997, Advances in cancer research.