Thermal-light full-field optical coherence tomography.

We have built a high-resolution optical coherence tomography (OCT) system, based on a Linnik-type interference microscope, illuminated by a white-light thermal lamp. The extremely short coherence length of the illumination source and the large aperture of the objectives permit resolution close to 1 microm in three dimensions. A parallel detection scheme with a CCD camera provides cross-section (x-y) image acquisition without scanning at a rate of up to 50 Hz. To our knowledge, our system has the highest resolution demonstrated to date for OCT imaging. With identical resolution in three dimensions, realistic volume rendering of structures inside biological tissues is possible.

[1]  M. V. van Gemert,et al.  Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. , 1997, Optics letters.

[2]  B. Colston,et al.  Birefringence characterization of biological tissue by use of optical coherence tomography. , 1998, Optics letters.

[3]  Harald Sattmann,et al.  A thermal light source technique for optical coherence tomography , 2000 .

[4]  J. Fujimoto,et al.  In vivo ultrahigh-resolution optical coherence tomography. , 1999, Optics letters.

[5]  A. Boccara,et al.  High-resolution full-field optical coherence tomography with a Linnik microscope. , 2002, Applied optics.

[6]  J. Fujimoto,et al.  Optical coherence microscopy in scattering media. , 1994, Optics letters.

[7]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[8]  H Saint-Jalmes,et al.  Full-field optical coherence microscopy. , 1998, Optics letters.

[9]  J. Fujimoto,et al.  In vivo retinal imaging by optical coherence tomography. , 1993, Optics letters.

[10]  J. Fujimoto,et al.  Spectroscopic optical coherence tomography. , 2000 .

[11]  J. Izatt,et al.  Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design. , 1999, Optics letters.

[12]  A. Dunn,et al.  Influence of optical properties on two-photon fluorescence imaging in turbid samples. , 2000, Applied optics.

[13]  P Seitz,et al.  Video-rate optical low-coherence reflectometry based on a linear smart detector array. , 2000, Optics letters.

[14]  J. Nelson,et al.  High-speed fiber based polarization-sensitive optical coherence tomography of in vivo human skin. , 2000, Optics letters.