The mixed model for multivariate repeated measures: validity conditions and an approximate test

Repeated measures on multivariate responses can be analyzed according to either of two models: a doubly multivariate model (DMM) or a multivariate mixed model (MMM). This paper reviews both models and gives three new results concerning the MMM. The first result is, primarily, of theoretical interest; the second and third have implications for practice. First, it is shown that, given multivariate normality, a condition called multivariate sphericity of the covariance matrix is both necessary and sufficient for the validity of the MMM analysis. To test for departure from multivariate sphericity, the likelihood ratio test can be employed. The second result is an approximation to the null distribution of the likelihood ratio test statistic, useful for moderate sample sizes. Third, for situations satisfying multivariate normality, but not multivariate sphericity, a multivariate ε correction factor is derived. The ε correction factor generalizes Box's ε and can be used to construct an adjusted MMM test.

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