A Measurement Setup and Automated Calculation Method to Determine the Charge Injection Capacity of Implantable Microelectrodes

The design of safe stimulation protocols for functional electrostimulation requires knowledge of the “maximum reversible charge injection capacity” of the implantable microelectrodes. One of the main difficulties encountered in characterizing such microelectrodes is the calculation of the access voltage Va. This paper proposes a method to calculate Va that does not require prior knowledge of the overpotential terms and of the electrolyte (or excitable tissue) resistance, which is an advantage for in vivo electrochemical characterization of microelectrodes. To validate this method, we compare the calculated results with those obtained from conventional methods for characterizing three flexible platinum microelectrodes by cyclic voltammetry and voltage transient measurements. This paper presents the experimental setup, the required instrumentation, and the signal processing.

[1]  Stuart F Cogan,et al.  Over-pulsing degrades activated iridium oxide films used for intracortical neural stimulation , 2004, Journal of Neuroscience Methods.

[2]  J. Avendaño Coy,et al.  Electroestimulación funcional en el lesionado medular (revisión científica) , 2001 .

[3]  Kip A Ludwig,et al.  Tissue damage thresholds during therapeutic electrical stimulation , 2016, Journal of neural engineering.

[4]  Ronald T. Leung,et al.  In Vivo and In Vitro Comparison of the Charge Injection Capacity of Platinum Macroelectrodes , 2015, IEEE Transactions on Biomedical Engineering.

[5]  E. Valderrama,et al.  Polyimide cuff electrodes for peripheral nerve stimulation , 2000, Journal of Neuroscience Methods.

[6]  Rajmohan Bhandari,et al.  Morphology and Electrochemical Properties of Activated and Sputtered Iridium Oxide Films for Functional Electrostimulation , 2012 .

[7]  W. Grill,et al.  Modeling the effects of electric fields on nerve fibers: influence of tissue electrical properties , 1999, IEEE Transactions on Biomedical Engineering.

[8]  S. Kelly,et al.  Perceptual efficacy of electrical stimulation of human retina with a microelectrode array during short-term surgical trials. , 2003, Investigative ophthalmology & visual science.

[9]  K. Hoffmann,et al.  A measurement set-up to determine the charge injection capacity of neural microelectrodes , 2009 .

[10]  Peter A. Robinson,et al.  Quantitative theory of deep brain stimulation of the subthalamic nucleus for the suppression of pathological rhythms in Parkinson’s disease , 2018, PLoS Comput. Biol..

[11]  Stuart F Cogan,et al.  Electrochemical characterization of high frequency stimulation electrodes: role of electrode material and stimulation parameters on electrode polarization , 2018, Journal of neural engineering.

[12]  Hans Dietl,et al.  Fully Implantable Multi-Channel Measurement System for Acquisition of Muscle Activity , 2013, IEEE Transactions on Instrumentation and Measurement.

[13]  Andreas Hierlemann,et al.  Impedance characterization and modeling of electrodes for biomedical applications , 2005, IEEE Transactions on Biomedical Engineering.

[14]  James C Weaver,et al.  An approach to electrical modeling of single and multiple cells , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[15]  James D. Weiland,et al.  Low-Impedance, High Surface Area Pt-Ir Electrodeposited on Cochlear Implant Electrodes , 2018 .

[16]  X.L. Chen,et al.  Deep Brain Stimulation , 2013, Interventional Neurology.

[17]  Ángel Gil-Agudo,et al.  Modelización de la Estimulación Eléctrica Neuromuscular mediante un enfoque fisiológico y de caja negra , 2016 .

[18]  S. B. Brummer,et al.  Electrochemical Considerations for Safe Electrical Stimulation of the Nervous System with Platinum Electrodes , 1977, IEEE Transactions on Biomedical Engineering.

[19]  W. Grill,et al.  Electrical properties of implant encapsulation tissue , 2006, Annals of Biomedical Engineering.

[20]  G. Clark.  The multiple-channel cochlear implant: the interface between sound and the central nervous system for hearing, speech, and language in deaf people—a personal perspective , 2006, Philosophical Transactions of the Royal Society B: Biological Sciences.

[21]  T.L. Rose,et al.  Electrical stimulation with Pt electrodes. VIII. Electrochemically safe charge injection limits with 0.2 ms pulses (neuronal application) , 1990, IEEE Transactions on Biomedical Engineering.

[22]  S. Cogan,et al.  Sputtered iridium oxide films for neural stimulation electrodes. , 2009, Journal of biomedical materials research. Part B, Applied biomaterials.

[23]  J. Pan,et al.  Investigation of Electrochemical Behavior of Stimulation'Sensing Materials for Pacemaker Electrode Applications I. Pt, Ti, and TiN Coated Electrodes , 2005 .

[24]  C. McIntyre,et al.  Extracellular stimulation of central neurons: influence of stimulus waveform and frequency on neuronal output. , 2002, Journal of neurophysiology.

[25]  F T Hambrecht.  Visual prostheses based on direct interfaces with the visual system. , 1995, Bailliere's clinical neurology.

[26]  S. Cogan.  Neural stimulation and recording electrodes. , 2008, Annual review of biomedical engineering.

[27]  Kin Fong Lei,et al.  Development of a Flexible Non-Metal Electrode for Cell Stimulation and Recording , 2016, Sensors.

[28]  J. Rozman,et al.  Electrochemical performance of platinum electrodes within the multi-electrode spiral nerve cuff , 2014, Australasian Physical & Engineering Sciences in Medicine.

[29]  Duygu Kuzum,et al.  Flexible Neural Electrode Array Based-on Porous Graphene for Cortical Microstimulation and Sensing , 2016, Scientific Reports.

[30]  Joseph F Rizzo,et al.  Thresholds for activation of rabbit retinal ganglion cells with a subretinal electrode. , 2006, Experimental eye research.

[31]  S. Mohtashami.  ELECTROCHEMICAL PROPERTIES OF FLEXIBLE ELECTRODES FOR IMPLANTED NEUROMUSCULAR EXCITATION APPLICATIONS , 2011 .

[32]  P. Peckham.  Functional electrical stimulation: current status and future prospects of applications to the neuromuscular system in spinal cord injury , 1987, Paraplegia.

[33]  Allen Taflove,et al.  Incorporation of the electrode–electrolyte interface into finite-element models of metal microelectrodes , 2008, Journal of neural engineering.

[34]  Daniel R. Merrill,et al.  Electrical stimulation of excitable tissue: design of efficacious and safe protocols , 2005, Journal of Neuroscience Methods.

[35]  T. Stieglitz,et al.  A novel platinum nanowire-coated neural electrode and its electrochemical and biological characterization , 2011, 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems.

[36]  P. Troyk,et al.  The influence of electrolyte composition on the in vitro charge-injection limits of activated iridium oxide (AIROF) stimulation electrodes , 2007, Journal of neural engineering.

[37]  Richard A Normann,et al.  Technology Insight: future neuroprosthetic therapies for disorders of the nervous system , 2007, Nature Clinical Practice Neurology.

[38]  A Kral,et al.  Recruitment of the auditory cortex in congenitally deaf cats by long-term cochlear electrostimulation. , 1999, Science.

[39]  J. Solomon,et al.  Comparison of transcutaneous electrical nerve stimulation (TENS) and functional electrical stimulation (FES) for spasticity in spinal cord injury - A pilot randomized cross-over trial , 2018, The journal of spinal cord medicine.