Resequencing and association analysis of coding regions at twenty candidate genes suggest a role for rare risk variation at AKAP9 and protective variation at NRXN1 in schizophrenia susceptibility.

[1]  T. Iidaka,et al.  Identification of Rare, Single-Nucleotide Mutations in NDE1 and Their Contributions to Schizophrenia Susceptibility. , 2015, Schizophrenia bulletin.

[2]  Eric E Schadt,et al.  A role for noncoding variation in schizophrenia. , 2014, Cell reports.

[3]  Á. Carracedo,et al.  Next generation sequencing challenges in the analysis of cardiac sudden death due to arrhythmogenic disorders , 2014, Electrophoresis.

[4]  M. Gill,et al.  Excess of rare novel loss-of-function variants in synaptic genes in schizophrenia and autism spectrum disorders , 2014, Molecular Psychiatry.

[5]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[6]  Janice M. Fullerton,et al.  Genome-wide association study reveals two new risk loci for bipolar disorder , 2014, Nature Communications.

[7]  J. Shendure,et al.  A general framework for estimating the relative pathogenicity of human genetic variants , 2014, Nature Genetics.

[8]  Eric S. Lander,et al.  A polygenic burden of rare disruptive mutations in schizophrenia , 2014, Nature.

[9]  E. Banks,et al.  De novo mutations in schizophrenia implicate synaptic networks , 2014, Nature.

[10]  J. Costas,et al.  Role of DISC1 Interacting Proteins in Schizophrenia Risk from Genome‐Wide Analysis of Missense SNPs , 2013, Annals of human genetics.

[11]  D. Clair,et al.  A survey of rare coding variants in candidate genes in schizophrenia by deep sequencing , 2013, Molecular Psychiatry.

[12]  Simon C. Potter,et al.  Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia , 2013, Nature Genetics.

[13]  M. Bang,et al.  A Matter of Balance: Role of Neurexin and Neuroligin at the Synapse , 2013, Neurochemical Research.

[14]  D. Boomsma,et al.  The evolutionary paradox and the missing heritability of schizophrenia , 2013, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[15]  J. Lieberman,et al.  Deep resequencing and association analysis of schizophrenia candidate genes , 2013, Molecular Psychiatry.

[16]  Kenny Q. Ye,et al.  An integrated map of genetic variation from 1,092 human genomes , 2012, Nature.

[17]  Jari Tiihonen,et al.  Exome sequencing followed by large-scale genotyping suggests a limited role for moderately rare risk factors of strong effect in schizophrenia. , 2012, American journal of human genetics.

[18]  K. Kaibuchi,et al.  Resequencing and association analysis of the KALRN and EPHB1 genes and their contribution to schizophrenia susceptibility. , 2012, Schizophrenia bulletin.

[19]  G. Baillie,et al.  cAMP: novel concepts in compartmentalised signalling. , 2012, Seminars in cell & developmental biology.

[20]  Atsushi Kamiya,et al.  DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders , 2012, Front. Psychiatry.

[21]  Christopher A. Miller,et al.  VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing. , 2012, Genome research.

[22]  Stephan Ripke,et al.  Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs , 2012, Nature Genetics.

[23]  M C O'Donovan,et al.  Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain , 2012, Molecular Psychiatry.

[24]  H. Stefánsson,et al.  Association Study of Nonsynonymous Single Nucleotide Polymorphisms in Schizophrenia , 2012, Biological Psychiatry.

[25]  Akira Sawa,et al.  Linking neurodevelopmental and synaptic theories of mental illness through DISC1 , 2011, Nature Reviews Neuroscience.

[26]  H. Stefánsson,et al.  Common variants at VRK2 and TCF4 conferring risk of schizophrenia. , 2011, Human molecular genetics.

[27]  Dan-Yu Lin,et al.  A general framework for detecting disease associations with rare variants in sequencing studies. , 2011, American journal of human genetics.

[28]  K. Van Steen,et al.  Sequencing of DISC1 Pathway Genes Reveals Increased Burden of Rare Missense Variants in Schizophrenia Patients from a Northern Swedish Population , 2011, PloS one.

[29]  Xihong Lin,et al.  Rare-variant association testing for sequencing data with the sequence kernel association test. , 2011, American journal of human genetics.

[30]  Mark L. Dell'Acqua,et al.  AKAP Signaling Complexes in Regulation of Excitatory Synaptic Plasticity , 2011, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[31]  Manuel Mattheisen,et al.  Resequencing and follow-up of neurexin 1 (NRXN1) in schizophrenia patients , 2011, Schizophrenia Research.

[32]  D. Rujescu,et al.  Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder , 2011, Molecular Psychiatry.

[33]  M. DePristo,et al.  A framework for variation discovery and genotyping using next-generation DNA sequencing data , 2011, Nature Genetics.

[34]  Laurent Mottron,et al.  Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia , 2011, Human Genetics.

[35]  Kathryn Roeder,et al.  Testing for an Unusual Distribution of Rare Variants , 2011, PLoS genetics.

[36]  N. Craddock,et al.  No evidence that rare coding variants in ZNF804A confer risk of schizophrenia , 2010, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.

[37]  D. MacArthur,et al.  Loss-of-function variants in the genomes of healthy humans. , 2010, Human molecular genetics.

[38]  A. Nekrutenko,et al.  Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences , 2010, Genome Biology.

[39]  Lee-Jen Wei,et al.  Pooled Association Tests for Rare Variants in Exon-Resequencing Studies , 2010 .

[40]  Daniel J. Blankenberg,et al.  Galaxy: A Web‐Based Genome Analysis Tool for Experimentalists , 2010, Current protocols in molecular biology.

[41]  Ken Chen,et al.  VarScan: variant detection in massively parallel sequencing of individual and pooled samples , 2009, Bioinform..

[42]  Pall I. Olason,et al.  Common variants conferring risk of schizophrenia , 2009, Nature.

[43]  P. Visscher,et al.  Common polygenic variation contributes to risk of schizophrenia and bipolar disorder , 2009, Nature.

[44]  T. Paunio,et al.  Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort , 2009, Molecular Psychiatry.

[45]  S. Browning,et al.  A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic , 2009, PLoS genetics.

[46]  Tyrone D. Cannon,et al.  Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study , 2009, The Lancet.

[47]  T. Südhof.  Neuroligins and neurexins link synaptic function to cognitive disease , 2008, Nature.

[48]  J. Buizer-Voskamp,et al.  Recurrent CNVs disrupt three candidate genes in schizophrenia patients. , 2008, American journal of human genetics.

[49]  John D. Scott,et al.  The A-kinase anchoring protein Yotiao binds and regulates adenylyl cyclase in brain , 2008, Proceedings of the National Academy of Sciences.

[50]  C. Spencer,et al.  Identification of loci associated with schizophrenia by genome-wide association and follow-up , 2008, Nature Genetics.

[51]  S. Cichon,et al.  Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement , 2008, Molecular Psychiatry.

[52]  J A Veltman,et al.  CNTNAP2 gene dosage variation is associated with schizophrenia and epilepsy , 2008, Molecular Psychiatry.

[53]  Tao Li,et al.  Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women , 2008, PLoS genetics.

[54]  Fikret Erdogan,et al.  Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. , 2007, Human molecular genetics.

[55]  Thomas Bourgeron,et al.  Mapping autism risk loci using genetic linkage and chromosomal rearrangements , 2007, Nature Genetics.

[56]  Daniel J. Blankenberg,et al.  Galaxy: a platform for interactive large-scale genome analysis. , 2005, Genome research.

[57]  P. Sullivan,et al.  Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. , 2003, Archives of general psychiatry.

[58]  Sheila Christie,et al.  Yeast two-hybrid screens implicate DISC1 in brain development and function. , 2003, Biochemical and biophysical research communications.

[59]  M. Merzenich,et al.  Model of autism: increased ratio of excitation/inhibition in key neural systems , 2003, Genes, brain, and behavior.

[60]  Y. Ono,et al.  Characterization of a Novel Giant Scaffolding Protein, CG-NAP, That Anchors Multiple Signaling Enzymes to Centrosome and the Golgi Apparatus* , 1999, The Journal of Biological Chemistry.

[61]  M. Pirinen,et al.  Common variant at 16p11.2 conferring risk of psychosis , 2014, Molecular Psychiatry.