High brachial-ankle pulse wave velocity is an independent predictor of the presence of coronary artery disease in men.

Pulse wave velocity (PWV) is an index of arterial stiffness, and a simple device for measuring brachial-ankle PWV (baPWV) has recently been developed. However, the clinical application of baPWV in patients with coronary artery disease (CAD) remains to be fully evaluated. This cross-sectional study was conducted to evaluate whether a higher baPWV predicts the presence of CAD. The baPWV was measured in 123 patients (77 males, 46 females; 63.5+/-11.8 years) who were undergoing coronary angiography. CAD was defined as >50% diameter stenosis. Hemodynamic data and cardiovascular risk factors were examined according to the presence or absence of CAD. Patients with CAD were significantly older across both sexes. The presence of hypertension and chest pain, but not baPWV, was correlated with CAD in females. The baPWV, and the presence of diabetes, hyperlipidemia, and chest pain were related to the presence of CAD in males. Multivariate logistic regression analysis in male patients showed that baPWV, diabetes, hyperlipidemia, and chest pain were independent risk factors for the presence of CAD. Furthermore, high baPWV in males with or without chest pain had a positive predictive value of 81.8% and 71.7% for the presence of CAD, respectively. In conclusion, high baPWV was shown to be a good independent predictor for the presence of CAD in men.

[1]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[2]  D Sapoznikov,et al.  Pulse wave velocity in healthy subjects and in patients with various disease states. , 1971, American heart journal.

[3]  R. Frye,et al.  A reporting system on patients evaluated for coronary artery disease. Report of the Ad Hoc Committee for Grading of Coronary Artery Disease, Council on Cardiovascular Surgery, American Heart Association. , 1975, Circulation.

[4]  V. J. Fisher,et al.  Complications of selective coronary arteriography by the Judkins technique and their prevention. , 1975, American heart journal.

[5]  A. Kagan,et al.  Atherosclerosis of the aorta and coronary arteries in five towns. Material and methods. , 1976, Bulletin of the World Health Organization.

[6]  J M Bland,et al.  Statistical methods for assessing agreement between two methods of clinical measurement , 1986 .

[7]  S. Sasayama,et al.  Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. , 1989, Circulation.

[8]  C. Hayward,et al.  Noninvasive determination of age-related changes in the human arterial pulse. , 1989, Circulation.

[9]  M. O'Rourke,et al.  Arterial stiffness, systolic blood pressure, and logical treatment of arterial hypertension. , 1990, Hypertension.

[10]  K Yamaoki,et al.  [Aortic pulse wave velocity in patients with coronary atherosclerosis--a comparison with coronary angiographic findings]. , 1991, Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.

[11]  A. Dart,et al.  Aortic distensibility in patients with isolated hypercholesterolaemia, coronary artery disease, or cardiac transplant , 1991, The Lancet.

[12]  W. Riley,et al.  Arterial stiffness: a new cardiovascular risk factor? , 1994, American journal of epidemiology.

[13]  T. Waddell,et al.  Hormonal therapy increases arterial compliance in postmenopausal women. , 1997, Journal of the American College of Cardiology.

[14]  M. Kähönen,et al.  Influence of captopril, propranolol, and verapamil on arterial pulse wave velocity and other cardiovascular parameters in healthy volunteers. , 1998, International journal of clinical pharmacology and therapeutics.

[15]  J. Blacher,et al.  Carotid arterial stiffness as a predictor of cardiovascular and all-cause mortality in end-stage renal disease. , 1998, Hypertension.

[16]  Hirofumi Tanaka,et al.  Absence of age-related increase in central arterial stiffness in physically active women. , 1998, Arteriosclerosis, thrombosis, and vascular biology.

[17]  A. Simon,et al.  Aortic stiffening does not predict coronary and extracoronary atherosclerosis in asymptomatic men at risk for cardiovascular disease. , 1998, American journal of hypertension.

[18]  J. Blacher,et al.  Impact of aortic stiffness on survival in end-stage renal disease. , 1999, Circulation.

[19]  J. Blacher,et al.  Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. , 1999, Hypertension.

[20]  P. Ducimetiere,et al.  Aortic Stiffness Is an Independent Predictor of All-Cause and Cardiovascular Mortality in Hypertensive Patients , 2001, Hypertension.

[21]  A. Hofman,et al.  Association Between Arterial Stiffness and Atherosclerosis: The Rotterdam Study , 2001, Stroke.

[22]  A. Dart,et al.  Simvastatin improves arterial compliance in the lower limb but not in the aorta. , 2001, Atherosclerosis.

[23]  P. Chowienczyk,et al.  Vasoactive Drugs Influence Aortic Augmentation Index Independently of Pulse-Wave Velocity in Healthy Men , 2001, Hypertension.

[24]  J. Ruidavets,et al.  Arterial stiffness and cardiovascular risk factors in a population-based study , 2000, Journal of hypertension.

[25]  T. Waddell,et al.  Carotid Pressure Is a Better Predictor of Coronary Artery Disease Severity Than Brachial Pressure , 2001, Hypertension.

[26]  M. E. Safar,et al.  Aortic Pulse Wave Velocity Predicts Cardiovascular Mortality in Subjects >70 Years of Age , 2001, Arteriosclerosis, thrombosis, and vascular biology.

[27]  A. Yamashina,et al.  Validity, reproducibility, and clinical significance of noninvasive brachial-ankle pulse wave velocity measurement. , 2002, Hypertension research : official journal of the Japanese Society of Hypertension.

[28]  S. Anderson,et al.  Aortic Pulse-Wave Velocity and Its Relationship to Mortality in Diabetes and Glucose Intolerance: An Integrated Index of Vascular Function? , 2002, Circulation.

[29]  Shigeaki Hinohara,et al.  Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement--a survey of 12517 subjects. , 2003, Atherosclerosis.

[30]  Hirofumi Tanaka,et al.  A new device for automatic measurements of arterial stiffness and ankle-brachial index. , 2003, The American journal of cardiology.

[31]  M. Iida,et al.  Usefulness of brachial-ankle pulse wave velocity measurement: correlation with abdominal aortic calcification. , 2003, Hypertension research : official journal of the Japanese Society of Hypertension.

[32]  Masanori Munakata,et al.  Utility of automated brachial ankle pulse wave velocity measurements in hypertensive patients. , 2003, American journal of hypertension.

[33]  Hirofumi Tanaka,et al.  P-279: A new screening device for automatic measurements of arterial stiffness and ankle-brachial index , 2003 .