Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as alpha-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies.
暂无分享,去创建一个
A. Ballestrero | F. Patrone | E. Moran | P. Vogel | A. Nencioni | G. Cirmena | A. Garuti | F. Grossi | F. Fruscione | B. Sordat | M. Cea | P. Pronzato | M. Duchosal | I. Rocco | M. Dupuis | C. Bello | A. Nahimana | Giovanna Dal Bello | Floriana Fruscione
[1] S. Withers,et al. Structural analysis of Golgi alpha-mannosidase II inhibitors identified from a focused glycosidase inhibitor screen. , 2008, Biochemistry.
[2] Eric Verdin,et al. Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. , 2008, Journal of medicinal chemistry.
[3] Ying Sun,et al. Design, synthesis, cytoselective toxicity, structure-activity relationships, and pharmacophore of thiazolidinone derivatives targeting drug-resistant lung cancer cells. , 2008, Journal of medicinal chemistry.
[4] R. Dwek,et al. Altered glycosylation of proteins in cancer: what is the potential for new anti-tumour strategies. , 2008, Anti-cancer agents in medicinal chemistry.
[5] J. B. Garrison,et al. Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity. , 2007, Cancer research.
[6] G. Fleet,et al. Looking glass inhibitors: synthesis of a potent naringinase inhibitor l-DIM [1,4-dideoxy-1,4-imino-l-mannitol], the enantiomer of DIM [1,4-dideoxy-1,4-imino-d-mannitol] a potent α-d-mannosidase inhibitor , 2007 .
[7] L. Juillerat-Jeanneret,et al. Synthesis of New Pyrrolidine Derivatives as Inhibitors of a-Mannosidase and of the Growth of Human Glioblastoma Cells , 2006 .
[8] M. Pfaffl,et al. Comparison of relative mRNA quantification models and the impact of RNA integrity in quantitative real-time RT-PCR , 2006, Biotechnology Letters.
[9] C. Bertozzi,et al. Glycans in cancer and inflammation — potential for therapeutics and diagnostics , 2005, Nature Reviews Drug Discovery.
[10] A. Ballestrero,et al. Cooperative Cytotoxicity of Proteasome Inhibitors and Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand in Chemoresistant Bcl-2-Overexpressing Cells , 2005, Clinical Cancer Research.
[11] L. Juillerat-Jeanneret,et al. Functionalized pyrrolidines inhibit alpha-mannosidase activity and growth of human glioblastoma and melanoma cells. , 2005, Journal of medicinal chemistry.
[12] L. Devy,et al. Anti-Invasive, Antitumoral, and Antiangiogenic Efficacy of a Pyrimidine-2,4,6-trione Derivative, an Orally Active and Selective Matrix Metalloproteinases Inhibitor , 2004, Clinical Cancer Research.
[13] A. Helenius,et al. Roles of N-linked glycans in the endoplasmic reticulum. , 2004, Annual review of biochemistry.
[14] D. Kuntz,et al. Comparison of kifunensine and 1-deoxymannojirimycin binding to class I and II alpha-mannosidases demonstrates different saccharide distortions in inverting and retaining catalytic mechanisms. , 2003, Biochemistry.
[15] P. Vogel,et al. Synthesis and glycosidase inhibitory activities of 2-(aminoalkyl)pyrrolidine-3,4-diol derivatives. , 2003, Bioorganic & medicinal chemistry.
[16] N. Asano. Glycosidase inhibitors: update and perspectives on practical use. , 2003, Glycobiology.
[17] E. Trombetta,et al. The contribution of N-glycans and their processing in the endoplasmic reticulum to glycoprotein biosynthesis. , 2003, Glycobiology.
[18] R. Dwek,et al. Membrane disruption and cytotoxicity of hydrophobic N-alkylated imino sugars is independent of the inhibition of protein and lipid glycosylation. , 2003, The Biochemical journal.
[19] H. Freeze. Human disorders in N-glycosylation and animal models. , 2002, Biochimica et biophysica acta.
[20] S. Hakomori,et al. Glycosylation defining cancer malignancy: New wine in an old bottle , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[21] P. Vogel,et al. An Efficient Combinatorial Method for the Discovery of Glycosidase Inhibitors , 2002, Chembiochem : a European journal of chemical biology.
[22] Luyi Guo,et al. Synthesis and mannosidase inhibitory activity of 3-benzyloxymethyl analogs of swainsonine , 2001 .
[23] E. Hembre,et al. Synthesis and mannosidase inhibitory activity of 6- and 7-substituted analogs of swainsonine , 2001 .
[24] A. Ballestrero,et al. Reverse‐transcriptase polymerase chain reaction of the maspin gene in the detection of bone marrow breast carcinoma cell contamination , 2001, Cancer.
[25] P. Vogel,et al. Derivatives of (2R, 3R, 4S)-2-aminomethylpyrrolidine-3,4-diol are selective α-mannosidase inhibitors , 2001 .
[26] D. Kuntz,et al. Structure of Golgi α‐mannosidase II: a target for inhibition of growth and metastasis of cancer cells , 2001, The EMBO journal.
[27] C. Belka,et al. Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL , 2001, Oncogene.
[28] C. Barberis,et al. Rapid access to N-Boc phenylglycine derivatives via benzylic lithiation reactions , 2001 .
[29] A. Helenius,et al. Intracellular functions of N-linked glycans. , 2001, Science.
[30] J. Dennis,et al. Glycoprotein glycosylation and cancer progression. , 1999, Biochimica et biophysica acta.
[31] A. Herscovics,et al. Importance of glycosidases in mammalian glycoprotein biosynthesis. , 1999, Biochimica et biophysica acta.
[32] A. Herscovics,et al. Substrate specificities of recombinant murine Golgi alpha1, 2-mannosidases IA and IB and comparison with endoplasmic reticulum and Golgi processing alpha1,2-mannosidases. , 1998, Glycobiology.
[33] S. Withers,et al. Identification of the Active Site Nucleophile in Jack Bean α-Mannosidase Using 5-Fluoro-β-l-Gulosyl Fluoride* , 1998, The Journal of Biological Chemistry.
[34] W. Shieh,et al. Asymmetric Synthesis of N-Substituted alpha-Aminobenzlactam via Crystallization-Induced Asymmetric Transformation of Covalent Diastereomer. , 1997, The Journal of organic chemistry.
[35] S. Withers,et al. Human lysosomal and jack bean alpha-mannosidases are retaining glycosidases. , 1997, Biochemical and biophysical research communications.
[36] P. Goss,et al. Phase IB clinical trial of the oligosaccharide processing inhibitor swainsonine in patients with advanced malignancies. , 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.
[37] D C Linch,et al. Prognostic significance of BCL-2 expression and bcl-2 major breakpoint region rearrangement in diffuse large cell non-Hodgkin's lymphoma: a British National Lymphoma Investigation Study. , 1996, Blood.
[38] J Hermans,et al. Clinical significance of bcl2 and p53 protein expression in diffuse large B-cell lymphoma: a population-based study. , 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[39] Stefano Cicchi,et al. Assignment of the Absolute Configuration of Natural Lentiginosine by Synthesis and Enzymic Assays of Optically Pure (+) and (-)-Enantiomers , 1995 .
[40] J. Dennis,et al. Inhibitors of carbohydrate processing: A new class of anticancer agents. , 1995, Clinical Cancer Research.
[41] R. Spiro,et al. Demonstration that a kifunensine-resistant alpha-mannosidase with a unique processing action on N-linked oligosaccharides occurs in rat liver endoplasmic reticulum and various cultured cells. , 1993, The Journal of biological chemistry.
[42] K. Olden,et al. The potential importance of swainsonine in therapy for cancers and immunology. , 1991, Pharmacology & therapeutics.
[43] M. Oken,et al. bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma. , 1989, The New England journal of medicine.
[44] S. Korsmeyer,et al. bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation , 1989, Cell.
[45] F. Wudl,et al. Bis(ethylenedioxy)tetrathiafulvalene: the first oxygen-substituted tetrathiafulvalene , 1989 .
[46] N. Miyaura,et al. Palladium-catalyzed inter- and intramolecular cross-coupling reactions of B-alkyl-9-borabicyclo[3.3.1]nonane derivatives with 1-halo-1-alkenes or haloarenes. Syntheses of functionalized alkenes, arenes, and cycloalkenes via a hydroboration-coupling sequence , 1989 .
[47] David L. Vaux,et al. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells , 1988, Nature.
[48] B. Winchester,et al. Synthesis from d-mannose of 1,4-dideoxy-1,4-imino-l-ribitol and of the α-mannosidase inhibitor 1,4-dideoxy-1,4-imino-d-talitol , 1988 .
[49] E. Egert,et al. Optically Active α-Arylglycine Esters by Friedel-Crafts Alkylation with the Chiral Cation of the Bislactim Ether of cyclo-(L-Val-Gly)† , 1987 .
[50] K. Nakahara,et al. Studies of an immunomodulator, swainsonine. II. Effect of swainsonine on mouse immunodeficient system and experimental murine tumor. , 1985, The Journal of antibiotics.
[51] S. Hakomori,et al. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: overview and perspectives. , 1985, Cancer research.
[52] S. Kornfeld,et al. Assembly of asparagine-linked oligosaccharides. , 1985, Annual review of biochemistry.
[53] A. Elbein,et al. Castanospermine, a tetrahydroxylated alkaloid that inhibits β-glucosidase and β-glucocerebrosidase , 1983 .
[54] C. Huxtable,et al. Inhibition of lysosomal alpha-mannosidase by swainsonine, an indolizidine alkaloid isolated from Swainsona canescens. , 1980, The Biochemical journal.
[55] G. Just,et al. β-Lactams. V. The synthesis of D,L-4-hydroxymethylnocardicin A (17N), D,L-4-hydroxymethyl-N-phenylacetylnocardicinic acid (8N-f), and their α-epimers 17U and 8U-f , 1979 .