How small peptides block and reverse serpin polymerisation.

[1]  P. Stein,et al.  Serpin Polymerization Is Prevented by a Hydrogen Bond Network That Is Centered on His-334 and Stabilized by Glycerol* , 2003, The Journal of Biological Chemistry.

[2]  David A. Lomas,et al.  Human genetics and disease: Serpinopathies and the conformational dementias , 2002, Nature Reviews Genetics.

[3]  D. Lomas,et al.  6-mer Peptide Selectively Anneals to a Pathogenic Serpin Conformation and Blocks Polymerization , 2002, The Journal of Biological Chemistry.

[4]  D. Lomas,et al.  Alpha1-antitrypsin deficiency--a model for conformational diseases. , 2002, The New England journal of medicine.

[5]  D. Selkoe.  Alzheimer's disease: genes, proteins, and therapy. , 2001, Physiological reviews.

[6]  J. Whisstock,et al.  Cleaved antitrypsin polymers at atomic resolution , 2008, Protein science : a publication of the Protein Society.

[7]  R. Read,et al.  Structure of a serpin–protease complex shows inhibition by deformation , 2000, Nature.

[8]  P. Lansbury,et al.  Acceleration of oligomerization, not fibrillization, is a shared property of both alpha-synuclein mutations linked to early-onset Parkinson's disease: implications for pathogenesis and therapy. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[9]  R. Read,et al.  Inactive conformation of the serpin alpha(1)-antichymotrypsin indicates two-stage insertion of the reactive loop: implications for inhibitory function and conformational disease. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. Read,et al.  A 2.6 A structure of a serpin polymer and implications for conformational disease. , 1999, Journal of molecular biology.

[11]  D. Lomas,et al.  Familial dementia caused by polymerization of mutant neuroserpin , 1999, Nature.

[12]  R M Esnouf,et al.  Further additions to MolScript version 1.4, including reading and contouring of electron-density maps. , 1999, Acta crystallographica. Section D, Biological crystallography.

[13]  D E McRee,et al.  XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density. , 1999, Journal of structural biology.

[14]  R. Carrell,et al.  Conformational changes and disease--serpins, prions and Alzheimer's. , 1998, Current opinion in structural biology.

[15]  J. Abrahams,et al.  Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin. , 1998, Journal of molecular biology.

[16]  Aiwu Zhou,et al.  Antithrombins Wibble and Wobble (T85M/K): archetypal conformational diseases with in vivo latent-transition, thrombosis, and heparin activation. , 1998, Blood.

[17]  R J Read,et al.  Crystallography & NMR system: A new software suite for macromolecular structure determination. , 1998, Acta crystallographica. Section D, Biological crystallography.

[18]  D. Musil,et al.  Interfering with the inhibitory mechanism of serpins: crystal structure of a complex formed between cleaved plasminogen activator inhibitor type 1 and a reactive-centre loop peptide. , 1998, Structure.

[19]  F. Cohen,et al.  Prion Protein Biology , 1998, Cell.

[20]  J. Abrahams,et al.  The anticoagulant activation of antithrombin by heparin. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[21]  R. Carrell,et al.  Mechanisms of antithrombin polymerisation and heparin activation probed by the insertion of synthetic reactive loop peptides. , 1997, Biological chemistry.

[22]  P. Andrew Karplus,et al.  Improved R-factors for diffraction data analysis in macromolecular crystallography , 1997, Nature Structural Biology.

[23]  J. Whisstock,et al.  Importance of the release of strand 1C to the polymerization mechanism of inhibitory serpins , 1997, Protein science : a publication of the Protein Society.

[24]  E A Merritt,et al.  Raster3D: photorealistic molecular graphics. , 1997, Methods in enzymology.

[25]  R. Read,et al.  Improved Structure Refinement Through Maximum Likelihood , 1996 .

[26]  P. Stein,et al.  Biological implications of a 3 A structure of dimeric antithrombin. , 1994, Structure.

[27]  M. Delarue,et al.  Crystal structure of cleaved bovine antithrombin III at 3.2 A resolution. , 1993, Journal of molecular biology.

[28]  D. Lomas,et al.  Effect of the Z mutation on the physical and inhibitory properties of alpha 1-antitrypsin. , 1993, Biochemistry.

[29]  D. Lomas,et al.  The mechanism of Z α1-antitrypsin accumulation in the liver , 1993, Nature.

[30]  J. Enghild,et al.  Conformation of the reactive site loop of alpha 1-proteinase inhibitor probed by limited proteolysis. , 1992, Biochemistry.

[31]  S. Olson,et al.  Conversion of antithrombin from an inhibitor of thrombin to a substrate with reduced heparin affinity and enhanced conformational stability by binding of a tetradecapeptide corresponding to the P1 to P14 region of the putative reactive bond loop of the inhibitor. , 1992, The Journal of biological chemistry.

[32]  P. Kraulis.  A program to produce both detailed and schematic plots of protein structures , 1991 .

[33]  J. Zou,et al.  Improved methods for building protein models in electron density maps and the location of errors in these models. , 1991, Acta crystallographica. Section A, Foundations of crystallography.

[34]  R. Huber,et al.  Structural transition of α1‐antitrypsin by a peptide sequentially similar to β‐strand s4A , 1990 .

[35]  R. Huber,et al.  Human alpha 1-proteinase inhibitor. Crystal structure analysis of two crystal modifications, molecular model and preliminary analysis of the implications for function. , 1984, Journal of molecular biology.

[36]  W. Krivit,et al.  Cirrhosis associated with alpha-1-antitrypsin deficiency: a previously unrecognized inherited disorder. , 1969, The Journal of laboratory and clinical medicine.

[37]  C. Laurell,et al.  The Electrophoretic α;1-Globulin Pattern of Serum in α;1-Antitrypsin Deficiency , 1963 .