The capillary dysfunction hypothesis of Alzheimer's disease

[1]  Berislav V. Zlokovic,et al.  Apolipoprotein E controls cerebrovascular integrity via cyclophilin A , 2012, Nature.

[2]  G. Reynolds,et al.  Hepatitis C virus infects the endothelial cells of the blood-brain barrier. , 2012, Gastroenterology.

[3]  D. Geschwind,et al.  Increased fMRI signal with age in familial Alzheimer's disease mutation carriers , 2012, Neurobiology of Aging.

[4]  Clare E. Mackay,et al.  The effects of APOE-ε4 on the BOLD response , 2012, Neurobiology of Aging.

[5]  B. Zlokovic.  Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders , 2011, Nature Reviews Neuroscience.

[6]  Leif Østergaard,et al.  The roles of cerebral blood flow, capillary transit time heterogeneity, and oxygen tension in brain oxygenation and metabolism , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  G. Semenza,et al.  Hypoxia‐inducible factor 1 mediates increased expression of NADPH oxidase‐2 in response to intermittent hypoxia , 2011, Journal of cellular physiology.

[8]  B. Zlokovic,et al.  Central nervous system pericytes in health and disease , 2011, Nature Neuroscience.

[9]  M. West,et al.  Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model , 2011, Neurobiology of Aging.

[10]  P. Grammas,et al.  Brain microvasculature and hypoxia-related proteins in Alzheimer's disease. , 2011, International journal of clinical and experimental pathology.

[11]  J. Tanus-Santos,et al.  Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. , 2011, Free radical biology & medicine.

[12]  T. Dalkara,et al.  Brain microvascular pericytes in health and disease , 2011, Acta Neuropathologica.

[13]  J. Rusted,et al.  Cognitive enhancement following acute losartan in normotensive young adults , 2011, Psychopharmacology.

[14]  P. Grammas,et al.  Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease , 2011, Journal of Neuroinflammation.

[15]  C. Iadecola,et al.  Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β , 2011, Proceedings of the National Academy of Sciences.

[16]  Peter Carmeliet,et al.  Hypoxia and inflammation. , 2011, The New England journal of medicine.

[17]  Ulrich Dirnagl,et al.  Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain , 2010, Proceedings of the National Academy of Sciences.

[18]  R. Deane,et al.  Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain , 2010, Journal of neurochemistry.

[19]  R. Kalaria.  Vascular basis for brain degeneration: faltering controls and risk factors for dementia. , 2010, Nutrition reviews.

[20]  Bengt R. Johansson,et al.  Pericytes regulate the blood–brain barrier , 2010, Nature.

[21]  B. Barres,et al.  Pericytes are required for blood–brain barrier integrity during embryogenesis , 2010, Nature.

[22]  D. Attwell,et al.  Glial and neuronal control of brain blood flow , 2010, Nature.

[23]  Berislav V. Zlokovic,et al.  Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging , 2010, Neuron.

[24]  J. Kountouras,et al.  Five-year Survival After Helicobacter pylori Eradication in Alzheimer Disease Patients , 2010, Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology.

[25]  C. Iadecola.  The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia , 2010, Acta Neuropathologica.

[26]  L. Pantoni.  Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges , 2010, The Lancet Neurology.

[27]  S. Ancoli-Israel,et al.  Sleep-disordered breathing, hypoxia, and risk of mild cognitive impairment and dementia in older women. , 2011, JAMA.

[28]  W. Le,et al.  Pathological role of hypoxia in Alzheimer's disease , 2010, Experimental Neurology.

[29]  Yaakov Stern,et al.  Food combination and Alzheimer disease risk: a protective diet. , 2010, Archives of neurology.

[30]  M. Kivipelto,et al.  Caffeine as a protective factor in dementia and Alzheimer's disease. , 2010, Journal of Alzheimer's disease : JAD.

[31]  D. Attwell,et al.  Pericyte-Mediated Regulation of Capillary Diameter: A Component of Neurovascular Coupling in Health and Disease , 2010, Front. Neuroenerg..

[32]  Ulrich Dirnagl,et al.  Pharmacological Uncoupling of Activation Induced Increases in CBF and CMRO2 , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[33]  David J. Begley,et al.  Structure and function of the blood–brain barrier , 2010, Neurobiology of Disease.

[34]  G. Dienel,et al.  Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes , 2010, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[35]  V. Hachinski,et al.  Changing perspectives regarding late-life dementia , 2009, Nature Reviews Neurology.

[36]  T. Ogihara,et al.  Angiotensin Receptor Blocker Prevented &bgr;-Amyloid–Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling , 2009, Hypertension.

[37]  Anders M. Dale,et al.  Cerebral perfusion and oxygenation differences in Alzheimer's disease risk , 2009, Neurobiology of Aging.

[38]  Mark E Kunik,et al.  Does use of antihypertensive drugs affect the incidence or progression of dementia? A systematic review. , 2009, The American journal of geriatric pharmacotherapy.

[39]  Satoru Hayasaka,et al.  The effect of daily caffeine use on cerebral blood flow: How much caffeine can we tolerate? , 2009, Human brain mapping.

[40]  K. Krause,et al.  NOX enzymes in the central nervous system: from signaling to disease. , 2009, Antioxidants & redox signaling.

[41]  V. Perry,et al.  Systemic inflammation and disease progression in Alzheimer disease , 2009, Neurology.

[42]  Turgay Dalkara,et al.  Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery , 2009, Nature Medicine.

[43]  M. Gladwin,et al.  Nitrite as regulator of hypoxic signaling in mammalian physiology , 2009, Medicinal research reviews.

[44]  Todd B. Parrish,et al.  Caffeine dose effect on activation-induced BOLD and CBF responses , 2009, NeuroImage.

[45]  P. Matthews,et al.  Distinct patterns of brain activity in young carriers of the APOE e4 allele , 2009, NeuroImage.

[46]  Berislav V. Zlokovic,et al.  Neurovascular mechanisms and blood–brain barrier disorder in Alzheimer’s disease , 2009, Acta Neuropathologica.

[47]  M. Tsolaki,et al.  Eradication of Helicobacter pylori may be beneficial in the management of Alzheimer’s disease , 2009, Journal of Neurology.

[48]  R. Deane,et al.  SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells , 2009, Nature Cell Biology.

[49]  D. Borchelt,et al.  Amyloid Pathology Is Associated with Progressive Monoaminergic Neurodegeneration in a Transgenic Mouse Model of Alzheimer's Disease , 2008, The Journal of Neuroscience.

[50]  S. Ancoli-Israel,et al.  Cognitive Effects of Treating Obstructive Sleep Apnea in Alzheimer's Disease: A Randomized Controlled Study , 2008, Journal of the American Geriatrics Society.

[51]  C. Iadecola,et al.  Hypertension and cerebrovascular dysfunction. , 2008, Cell metabolism.

[52]  P. Cumming,et al.  Effect of memantine on CBF and CMRO2 in patients with early Parkinson’s disease , 2008, Acta neurologica Scandinavica.

[53]  Bojana Stefanovic,et al.  Functional Reactivity of Cerebral Capillaries , 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[54]  R. Carare,et al.  Perivascular drainage of amyloid-beta peptides from the brain and its failure in cerebral amyloid angiopathy and Alzheimer's disease. , 2008, Brain pathology.

[55]  W. Hoefnagels,et al.  No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial , 2008, PloS one.

[56]  R. Carare,et al.  SYMPOSIUM: Clearance of Aβ from the Brain in Alzheimer's Disease: Perivascular Drainage of Amyloid‐β Peptides from the Brain and Its Failure in Cerebral Amyloid Angiopathy and Alzheimer's Disease , 2007 .

[57]  M. Verbeek,et al.  Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells. , 2007, The American journal of pathology.

[58]  J. LaManna,et al.  Physiologic angiodynamics in the brain. , 2007, Antioxidants & redox signaling.

[59]  Patrick L. McGeer,et al.  NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies , 2007, Neurobiology of Aging.

[60]  D. Holtzman,et al.  Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System , 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[61]  Andrew Brooks,et al.  Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype , 2007, Proceedings of the National Academy of Sciences.

[62]  Hong Qing,et al.  Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression , 2006, Proceedings of the National Academy of Sciences.

[63]  L. Zacharia,et al.  Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production , 2006, Neuroscience.

[64]  D. Attwell,et al.  Bidirectional control of CNS capillary diameter by pericytes , 2006, Nature.

[65]  P. Hof,et al.  Stereologic Analysis of Microvascular Morphology in the Elderly: Alzheimer Disease Pathology and Cognitive Status , 2006, Journal of neuropathology and experimental neurology.

[66]  E. Hamel.  Perivascular nerves and the regulation of cerebrovascular tone. , 2006, Journal of applied physiology.

[67]  D. Puro,et al.  Extracellular lactate as a dynamic vasoactive signal in the rat retinal microvasculature. , 2006, American journal of physiology. Heart and circulatory physiology.

[68]  C. J. Rivara,et al.  Cognitive impact of neuronal pathology in the entorhinal cortex and CA1 field in Alzheimer's disease , 2006, Neurobiology of Aging.

[69]  Hiroshi Matsuda,et al.  The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT , 2005, NeuroImage.

[70]  Y. Stern,et al.  APOE related alterations in cerebral activation even at college age , 2005, Journal of Neurology, Neurosurgery & Psychiatry.

[71]  Benjamin J. Shannon,et al.  Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory , 2005, The Journal of Neuroscience.

[72]  Don L. Armstrong,et al.  Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease , 2005, Nature Medicine.

[73]  M. Tymianski,et al.  TRPMs and neuronal cell death , 2005, Pflügers Archiv.

[74]  E. Klann,et al.  NADPH oxidase is required for NMDA receptor‐dependent activation of ERK in hippocampal area CA1 , 2005, Journal of neurochemistry.

[75]  A. Hofman,et al.  Cerebral hypoperfusion and clinical onset of dementia: The Rotterdam study , 2005, Annals of neurology.

[76]  Barbara L. Hempstead,et al.  ProBDNF Induces Neuronal Apoptosis via Activation of a Receptor Complex of p75NTR and Sortilin , 2005, The Journal of Neuroscience.

[77]  D. Puro,et al.  Effects of angiotensin II on the pericyte‐containing microvasculature of the rat retina , 2004, The Journal of physiology.

[78]  C. Iadecola,et al.  Angiotensin II Impairs Neurovascular Coupling in Neocortex Through NADPH Oxidase–Derived Radicals , 2004, Circulation research.

[79]  Petti T. Pang,et al.  Cleavage of proBDNF by tPA/Plasmin Is Essential for Long-Term Hippocampal Plasticity , 2004, Science.

[80]  Peter J. Lenting,et al.  LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms , 2004, Neuron.

[81]  G. Alexander,et al.  Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[82]  C. Iadecola,et al.  Angiotensin II attenuates functional hyperemia in the mouse somatosensory cortex. , 2003, American journal of physiology. Heart and circulatory physiology.

[83]  Y. Stern,et al.  APOE genotype and cerebral blood flow in healthy young individuals. , 2003, JAMA.

[84]  Rachelle Doody,et al.  Memantine in moderate-to-severe Alzheimer's disease. , 2003, The New England journal of medicine.

[85]  M. L. Schulte,et al.  Cortical electrical stimulation alters erythrocyte perfusion pattern in the cerebral capillary network of the rat , 2003, Brain Research.

[86]  D. Selkoe,et al.  The Amyloid Hypothesis of Alzheimer's Disease: Progress and Problems on the Road to Therapeutics , 2002, Science.

[87]  A. de Mendonça,et al.  Does caffeine intake protect from Alzheimer's disease? , 2002, European journal of neurology.

[88]  D. Cornfield,et al.  Aβ-peptides enhance vasoconstriction in cerebral circulation , 2001 .

[89]  P. Luiten,et al.  Cerebral microvascular pathology in aging and Alzheimer's disease , 2001, Progress in Neurobiology.

[90]  A. Nunomura,et al.  Oxidative Damage Is the Earliest Event in Alzheimer Disease , 2001, Journal of neuropathology and experimental neurology.

[91]  D. Holtzman,et al.  Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. , 2000, The Journal of clinical investigation.

[92]  W. Jagust.  Neuroimaging in dementia. , 2000, Neurologic clinics.

[93]  Mark S. Cohen,et al.  Patterns of brain activation in people at risk for Alzheimer's disease. , 2000, The New England journal of medicine.

[94]  C. Iadecola,et al.  Abeta 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[95]  J. Rafols,et al.  Pericyte migration from the vascular wall in response to traumatic brain injury. , 2000, Microvascular research.

[96]  B R Rosen,et al.  Combined diffusion-weighted and perfusion-weighted flow heterogeneity magnetic resonance imaging in acute stroke. , 2000, Stroke.

[97]  W. Thomas,et al.  Brain macrophages: on the role of pericytes and perivascular cells , 1999, Brain Research Reviews.

[98]  D. Iarussi,et al.  Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients. , 1999, American journal of hypertension.

[99]  B. Rosen,et al.  Modeling Cerebral Blood Flow and Flow Heterogeneity from Magnetic Resonance Residue Data , 1999, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[100]  D. Borchelt,et al.  SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein , 1999, Nature Neuroscience.

[101]  D. Kleinfeld,et al.  Fluctuations and stimulus-induced changes in blood flow observed in individual capillaries in layers 2 through 4 of rat neocortex. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[102]  W. Mayhan,et al.  Nicotine impairs histamine-induced increases in macromolecular efflux: role of oxygen radicals. , 1998, Journal of applied physiology.

[103]  T. L. Davis,et al.  Calibrated functional MRI: mapping the dynamics of oxidative metabolism. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[104]  B B Biswal,et al.  Effects of hypoxia and hypercapnia on capillary flow velocity in the rat cerebral cortex. , 1997, Microvascular research.

[105]  D. R. Anderson,et al.  Oxygen modulation of guanylate cyclase-mediated retinal pericyte relaxations with 3-morpholino-sydnonimine and atrial natriuretic peptide. , 1997, Investigative ophthalmology & visual science.

[106]  M. Dehouck,et al.  Endothelin-1 as a Mediator of Endothelial Cell–Pericyte Interactions in Bovine Brain Capillaries , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[107]  D. R. Anderson,et al.  Suppression of CO2-induced relaxation of bovine retinal pericytes by angiotensin II. , 1997, Investigative ophthalmology & visual science.

[108]  M. Verbeek,et al.  Rapid Degeneration of Cultured Human Brain Pericytes by Amyloid β Protein , 1997 .

[109]  W. Kuschinsky,et al.  Decreased Heterogeneity of Capillary Plasma Flow in the Rat Whisker-Barrel Cortex during Functional Hyperemia , 1996, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[110]  G. Schmid-Schönbein,et al.  Mechanisms and consequences of cell activation in the microcirculation. , 1996, Cardiovascular research.

[111]  P. Hedera,et al.  Differential degeneration of the cerebral microvasculature in Alzheimer's disease. , 1995, Neuroreport.

[112]  J. Troncoso,et al.  Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease , 1994, The Lancet.

[113]  A. Villringer,et al.  Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study. , 1994, Circulation research.

[114]  D. R. Anderson,et al.  Relaxation of retinal pericyte contractile tone through the nitric oxide-cyclic guanosine monophosphate pathway. , 1994, Investigative ophthalmology & visual science.

[115]  J. Haines,et al.  Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. , 1993, Science.

[116]  A. Kaszniak,et al.  Clinical trial of indomethacin in Alzheimer's disease , 1993, Neurology.

[117]  G. Cold,et al.  The effect of indomethacin upon cerebral blood flow in healthy volunteers , 1993, Acta Neurochirurgica.

[118]  Y. Yamori,et al.  Ultrastructural changes in cerebral pericytes and astrocytes of stroke-prone spontaneously hypertensive rats. , 1990, Stroke.

[119]  H. Chui,et al.  Microangiopathy, the vascular basement membrane and Alzheimer's disease: a review , 1990, Brain Research Bulletin.

[120]  A. Scheibel,et al.  DENERVATION MICROANGIOPATHY IN SENILE DEMENTIA, ALZHEIMER TYPE , 1987, Alzheimer disease and associated disorders.

[121]  E. M. Renkin,et al.  B. W. Zweifach Award lecture. Regulation of the microcirculation. , 1985, Microvascular research.

[122]  McCuskey Pa,et al.  In vivo and electron microscopic study of the development of cerebral diabetic microangiography. , 1984 .

[123]  W. Pardridge.  Brain metabolism: a perspective from the blood-brain barrier. , 1983, Physiological reviews.

[124]  P. Johnson,et al.  Thickened cerebral cortical capillary basement membranes in diabetics. , 1982, Archives of pathology & laboratory medicine.

[125]  G. Pawlik,et al.  Quantitative capillary topography and blood flow in the cerebral cortex of cats: an in vivo microscopic study , 1981, Brain Research.

[126]  G N Stewart,et al.  Researches on the Circulation Time in Organs and on the Influences which affect it , 1893, The Journal of physiology.

[127]  K. Mouridsen,et al.  Reliable estimation of capillary transit time distributions at voxel-level using DSC-MRI , 2011 .

[128]  L. White,et al.  Coffee intake in midlife and risk of dementia and its neuropathologic correlates. , 2011, Journal of Alzheimer's disease : JAD.

[129]  S. Resnick,et al.  APOE epsilon4 genotype and longitudinal changes in cerebral blood flow in normal aging. , 2010, Archives of neurology.

[130]  Seong-Gi Kim,et al.  Brain tissue oxygen consumption and supply induced by neural activation: determined under suppressed hemodynamic response conditions in the anesthetized rat cerebral cortex. , 2009, Advances in experimental medicine and biology.

[131]  L. Liaudet,et al.  Nitric oxide and peroxynitrite in health and disease. , 2007, Physiological reviews.

[132]  C. Iadecola,et al.  Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. , 2006, Journal of applied physiology.

[133]  U. Junker,et al.  Basement membrane of hypothalamus and cortex capillaries from normotensive and spontaneously hypertensive rats with streptozotocin-induced diabetes , 2004, Acta Neuropathologica.

[134]  A. Hudetz,et al.  Hypoxemia alters erythrocyte perfusion pattern in the cerebral capillary network. , 2000, Microvascular research.

[135]  R N Kalaria,et al.  Cerebral vessels in ageing and Alzheimer's disease. , 1996, Pharmacology & therapeutics.

[136]  D. R. Anderson,et al.  Glaucoma, capillaries and pericytes. 4. Beta-adrenergic activation of cultured retinal pericytes. , 1996, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[137]  D. R. Anderson,et al.  Glaucoma, capillaries and pericytes. 1. Blood flow regulation. , 1996, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde.

[138]  W. Kuschinsky,et al.  Patterns of capillary plasma perfusion in brains in conscious rats during normocapnia and hypercapnia. , 1995, Circulation research.

[139]  A. Moses,et al.  HIV infection of human brain capillary endothelial cells--implications for AIDS dementia. , 1994, Advances in neuroimmunology.

[140]  O. Paulson,et al.  Capillary circulation in the brain. , 1992, Cerebrovascular and brain metabolism reviews.

[141]  H. Karwacka.  Ultrastructural and biochemical studies of the brain and other organs in rats after chronic ethanol administration. I. Electronmicroscopic investigations of the morphologic elements of the blood-brain barrier in the rat after ethanol intoxication. , 1980, Experimentelle Pathologie.

[142]  J. Dymecki,et al.  Ultrastructural and biochemical studies of the brain and other organs in rat after chronic ethanol administration. III. Influence of ethanol intoxication on oxidative phosphorylation of the rat brain mitochondria with ultrastructural and morphometric evaluation of mitochondrial fraction). , 1980, Experimentelle Pathologie.